Surgical Outcomes of Hepatic Resection for Hepatitis B Virus Surface Antigen-Negative and Hepatitis C Virus Antibody-Negative Hepatocellular Carcinoma
Background The incidence of hepatitis B virus surface antigen-negative and hepatitis C virus antibody-negative hepatocellular carcinoma (NBNC-HCC) is gradually increasing. Methods A retrospective cohort study was performed in 694 patients who underwent curative hepatic resection for primary HCC from...
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| Veröffentlicht in: | Annals of surgical oncology 2015-07, Vol.22 (7), p.2279-2285 |
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| creator | Yamashita, Yo-ichi Imai, Daisuke Bekki, Yuki Kimura, Koichi Matsumoto, Yoshiriro Nakagawara, Hidekazu Ikegami, Toru Yoshizumi, Tomoharu Shirabe, Ken Aishima, Shinichi Maehara, Yoshihiko |
| description | Background
The incidence of hepatitis B virus surface antigen-negative and hepatitis C virus antibody-negative hepatocellular carcinoma (NBNC-HCC) is gradually increasing.
Methods
A retrospective cohort study was performed in 694 patients who underwent curative hepatic resection for primary HCC from January 1990 to December 2011.
Results
In the NBNC-HCC group (
n
= 110), the complication rate of diabetic mellitus (38 %) was significantly higher than that of the B-HCC group (
n
= 110; 17 %), and their rate of alcohol abuse (38 %) was significantly higher than that of both the B-HCC (26 %) and C-HCC groups (
n
= 474; 22 %). In the NBNC-HCC group, the tumor diameter (4.5 ± 3.6 cm) was significantly larger than that of the C-HCC group (2.9 ± 1.8 cm), but the rate of histological cirrhosis (37 %) was significantly lower than those of both the B-HCC (67 %) and C-HCC (53 %) groups. There were no significant differences regarding overall and disease-free survival among the three groups. In the NBNC-HCC group, multiple intrahepatic or distant recurrences (25 %) were significantly higher than in the C-HCC group (17 %), and the rate of recurrence more than 2 years after hepatic resection (24 %) was significantly higher than that of the B-HCC group (12 %).
Conclusions
The surgical outcomes of patients with NBNC-HCC were not significantly different compared with those of the patients with B-HCC or C-HCC. There was a substantial population with late recurrence among the patients with NBNC-HCC after curative hepatic resection, and thus not only long-term follow-up but also the early establishment of preventive methods for HCC recurrence from NBNC-hepatitis are necessary. |
| doi_str_mv | 10.1245/s10434-014-4261-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1709166812</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1709166812</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-2056d0bb154573c2ccbf80750b0455f7d9632abe0da90ae5b62a1e04ef9e02963</originalsourceid><addsrcrecordid>eNqF0ctq3DAUBmARUppbHyCbIsimG6dHsiTby2RoLhAaaJtshSwfDwq2NZHskrxInzdyZnKhULqSkL5zdPkJOWRwzLiQXyMDkYsMmMgEVyx72CK7TKYVoUq2neagyqziSu6QvRjvAFiRg_xIdrgUBVdC7ZI_P6ewdNZ09Hoare8xUt_SC1yZ0Vn6AyPa0fmBtj5sVkcX6Sm9dWGKNBW3xiI9GUa3xCH7jsskfiM1Q_OOLzZ8ZrVvHt_cs_EWu27qTKALE6wbfG8OyIfWdBE_bcZ9cnP27dfiIru6Pr9cnFxlVgo2ZhykaqCumRSyyC23tm5LKCTUIKRsi6ZSOTc1QmMqMChrxQ1DENhWCDxt7pMv676r4O8njKPuXZyvYwb0U9SsgIqp9Jv8_1SVqqrKvMgTPfqL3vkpDOkhz4ornvNZsbWywccYsNWr4HoTHjUDPeer1_nqlK-e89UPqebzpvNU99i8VrwEmgBfg5i2hiWGd0f_s-sT7XCxhw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1686262323</pqid></control><display><type>article</type><title>Surgical Outcomes of Hepatic Resection for Hepatitis B Virus Surface Antigen-Negative and Hepatitis C Virus Antibody-Negative Hepatocellular Carcinoma</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Yamashita, Yo-ichi ; Imai, Daisuke ; Bekki, Yuki ; Kimura, Koichi ; Matsumoto, Yoshiriro ; Nakagawara, Hidekazu ; Ikegami, Toru ; Yoshizumi, Tomoharu ; Shirabe, Ken ; Aishima, Shinichi ; Maehara, Yoshihiko</creator><creatorcontrib>Yamashita, Yo-ichi ; Imai, Daisuke ; Bekki, Yuki ; Kimura, Koichi ; Matsumoto, Yoshiriro ; Nakagawara, Hidekazu ; Ikegami, Toru ; Yoshizumi, Tomoharu ; Shirabe, Ken ; Aishima, Shinichi ; Maehara, Yoshihiko</creatorcontrib><description>Background
The incidence of hepatitis B virus surface antigen-negative and hepatitis C virus antibody-negative hepatocellular carcinoma (NBNC-HCC) is gradually increasing.
Methods
A retrospective cohort study was performed in 694 patients who underwent curative hepatic resection for primary HCC from January 1990 to December 2011.
Results
In the NBNC-HCC group (
n
= 110), the complication rate of diabetic mellitus (38 %) was significantly higher than that of the B-HCC group (
n
= 110; 17 %), and their rate of alcohol abuse (38 %) was significantly higher than that of both the B-HCC (26 %) and C-HCC groups (
n
= 474; 22 %). In the NBNC-HCC group, the tumor diameter (4.5 ± 3.6 cm) was significantly larger than that of the C-HCC group (2.9 ± 1.8 cm), but the rate of histological cirrhosis (37 %) was significantly lower than those of both the B-HCC (67 %) and C-HCC (53 %) groups. There were no significant differences regarding overall and disease-free survival among the three groups. In the NBNC-HCC group, multiple intrahepatic or distant recurrences (25 %) were significantly higher than in the C-HCC group (17 %), and the rate of recurrence more than 2 years after hepatic resection (24 %) was significantly higher than that of the B-HCC group (12 %).
Conclusions
The surgical outcomes of patients with NBNC-HCC were not significantly different compared with those of the patients with B-HCC or C-HCC. There was a substantial population with late recurrence among the patients with NBNC-HCC after curative hepatic resection, and thus not only long-term follow-up but also the early establishment of preventive methods for HCC recurrence from NBNC-hepatitis are necessary.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-014-4261-x</identifier><identifier>PMID: 25472646</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - surgery ; Carcinoma, Hepatocellular - virology ; Female ; Follow-Up Studies ; Hepatectomy - mortality ; Hepatitis B Surface Antigens - blood ; Hepatitis B virus ; Hepatitis C Antibodies - blood ; Hepatitis C virus ; Hepatobiliary Tumors ; Humans ; Liver Neoplasms - blood ; Liver Neoplasms - mortality ; Liver Neoplasms - surgery ; Liver Neoplasms - virology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Staging ; Oncology ; Prognosis ; Retrospective Studies ; Surgery ; Surgical Oncology ; Survival Rate</subject><ispartof>Annals of surgical oncology, 2015-07, Vol.22 (7), p.2279-2285</ispartof><rights>Society of Surgical Oncology 2014</rights><rights>Society of Surgical Oncology 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-2056d0bb154573c2ccbf80750b0455f7d9632abe0da90ae5b62a1e04ef9e02963</citedby><cites>FETCH-LOGICAL-c541t-2056d0bb154573c2ccbf80750b0455f7d9632abe0da90ae5b62a1e04ef9e02963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-014-4261-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-014-4261-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25472646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamashita, Yo-ichi</creatorcontrib><creatorcontrib>Imai, Daisuke</creatorcontrib><creatorcontrib>Bekki, Yuki</creatorcontrib><creatorcontrib>Kimura, Koichi</creatorcontrib><creatorcontrib>Matsumoto, Yoshiriro</creatorcontrib><creatorcontrib>Nakagawara, Hidekazu</creatorcontrib><creatorcontrib>Ikegami, Toru</creatorcontrib><creatorcontrib>Yoshizumi, Tomoharu</creatorcontrib><creatorcontrib>Shirabe, Ken</creatorcontrib><creatorcontrib>Aishima, Shinichi</creatorcontrib><creatorcontrib>Maehara, Yoshihiko</creatorcontrib><title>Surgical Outcomes of Hepatic Resection for Hepatitis B Virus Surface Antigen-Negative and Hepatitis C Virus Antibody-Negative Hepatocellular Carcinoma</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
The incidence of hepatitis B virus surface antigen-negative and hepatitis C virus antibody-negative hepatocellular carcinoma (NBNC-HCC) is gradually increasing.
Methods
A retrospective cohort study was performed in 694 patients who underwent curative hepatic resection for primary HCC from January 1990 to December 2011.
Results
In the NBNC-HCC group (
n
= 110), the complication rate of diabetic mellitus (38 %) was significantly higher than that of the B-HCC group (
n
= 110; 17 %), and their rate of alcohol abuse (38 %) was significantly higher than that of both the B-HCC (26 %) and C-HCC groups (
n
= 474; 22 %). In the NBNC-HCC group, the tumor diameter (4.5 ± 3.6 cm) was significantly larger than that of the C-HCC group (2.9 ± 1.8 cm), but the rate of histological cirrhosis (37 %) was significantly lower than those of both the B-HCC (67 %) and C-HCC (53 %) groups. There were no significant differences regarding overall and disease-free survival among the three groups. In the NBNC-HCC group, multiple intrahepatic or distant recurrences (25 %) were significantly higher than in the C-HCC group (17 %), and the rate of recurrence more than 2 years after hepatic resection (24 %) was significantly higher than that of the B-HCC group (12 %).
Conclusions
The surgical outcomes of patients with NBNC-HCC were not significantly different compared with those of the patients with B-HCC or C-HCC. There was a substantial population with late recurrence among the patients with NBNC-HCC after curative hepatic resection, and thus not only long-term follow-up but also the early establishment of preventive methods for HCC recurrence from NBNC-hepatitis are necessary.</description><subject>Aged</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Carcinoma, Hepatocellular - virology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hepatectomy - mortality</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis B virus</subject><subject>Hepatitis C Antibodies - blood</subject><subject>Hepatitis C virus</subject><subject>Hepatobiliary Tumors</subject><subject>Humans</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Neoplasms - virology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0ctq3DAUBmARUppbHyCbIsimG6dHsiTby2RoLhAaaJtshSwfDwq2NZHskrxInzdyZnKhULqSkL5zdPkJOWRwzLiQXyMDkYsMmMgEVyx72CK7TKYVoUq2neagyqziSu6QvRjvAFiRg_xIdrgUBVdC7ZI_P6ewdNZ09Hoare8xUt_SC1yZ0Vn6AyPa0fmBtj5sVkcX6Sm9dWGKNBW3xiI9GUa3xCH7jsskfiM1Q_OOLzZ8ZrVvHt_cs_EWu27qTKALE6wbfG8OyIfWdBE_bcZ9cnP27dfiIru6Pr9cnFxlVgo2ZhykaqCumRSyyC23tm5LKCTUIKRsi6ZSOTc1QmMqMChrxQ1DENhWCDxt7pMv676r4O8njKPuXZyvYwb0U9SsgIqp9Jv8_1SVqqrKvMgTPfqL3vkpDOkhz4ornvNZsbWywccYsNWr4HoTHjUDPeer1_nqlK-e89UPqebzpvNU99i8VrwEmgBfg5i2hiWGd0f_s-sT7XCxhw</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Yamashita, Yo-ichi</creator><creator>Imai, Daisuke</creator><creator>Bekki, Yuki</creator><creator>Kimura, Koichi</creator><creator>Matsumoto, Yoshiriro</creator><creator>Nakagawara, Hidekazu</creator><creator>Ikegami, Toru</creator><creator>Yoshizumi, Tomoharu</creator><creator>Shirabe, Ken</creator><creator>Aishima, Shinichi</creator><creator>Maehara, Yoshihiko</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U9</scope></search><sort><creationdate>20150701</creationdate><title>Surgical Outcomes of Hepatic Resection for Hepatitis B Virus Surface Antigen-Negative and Hepatitis C Virus Antibody-Negative Hepatocellular Carcinoma</title><author>Yamashita, Yo-ichi ; Imai, Daisuke ; Bekki, Yuki ; Kimura, Koichi ; Matsumoto, Yoshiriro ; Nakagawara, Hidekazu ; Ikegami, Toru ; Yoshizumi, Tomoharu ; Shirabe, Ken ; Aishima, Shinichi ; Maehara, Yoshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-2056d0bb154573c2ccbf80750b0455f7d9632abe0da90ae5b62a1e04ef9e02963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Carcinoma, Hepatocellular - virology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hepatectomy - mortality</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Hepatitis B virus</topic><topic>Hepatitis C Antibodies - blood</topic><topic>Hepatitis C virus</topic><topic>Hepatobiliary Tumors</topic><topic>Humans</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver Neoplasms - virology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamashita, Yo-ichi</creatorcontrib><creatorcontrib>Imai, Daisuke</creatorcontrib><creatorcontrib>Bekki, Yuki</creatorcontrib><creatorcontrib>Kimura, Koichi</creatorcontrib><creatorcontrib>Matsumoto, Yoshiriro</creatorcontrib><creatorcontrib>Nakagawara, Hidekazu</creatorcontrib><creatorcontrib>Ikegami, Toru</creatorcontrib><creatorcontrib>Yoshizumi, Tomoharu</creatorcontrib><creatorcontrib>Shirabe, Ken</creatorcontrib><creatorcontrib>Aishima, Shinichi</creatorcontrib><creatorcontrib>Maehara, Yoshihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamashita, Yo-ichi</au><au>Imai, Daisuke</au><au>Bekki, Yuki</au><au>Kimura, Koichi</au><au>Matsumoto, Yoshiriro</au><au>Nakagawara, Hidekazu</au><au>Ikegami, Toru</au><au>Yoshizumi, Tomoharu</au><au>Shirabe, Ken</au><au>Aishima, Shinichi</au><au>Maehara, Yoshihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surgical Outcomes of Hepatic Resection for Hepatitis B Virus Surface Antigen-Negative and Hepatitis C Virus Antibody-Negative Hepatocellular Carcinoma</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>22</volume><issue>7</issue><spage>2279</spage><epage>2285</epage><pages>2279-2285</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
The incidence of hepatitis B virus surface antigen-negative and hepatitis C virus antibody-negative hepatocellular carcinoma (NBNC-HCC) is gradually increasing.
Methods
A retrospective cohort study was performed in 694 patients who underwent curative hepatic resection for primary HCC from January 1990 to December 2011.
Results
In the NBNC-HCC group (
n
= 110), the complication rate of diabetic mellitus (38 %) was significantly higher than that of the B-HCC group (
n
= 110; 17 %), and their rate of alcohol abuse (38 %) was significantly higher than that of both the B-HCC (26 %) and C-HCC groups (
n
= 474; 22 %). In the NBNC-HCC group, the tumor diameter (4.5 ± 3.6 cm) was significantly larger than that of the C-HCC group (2.9 ± 1.8 cm), but the rate of histological cirrhosis (37 %) was significantly lower than those of both the B-HCC (67 %) and C-HCC (53 %) groups. There were no significant differences regarding overall and disease-free survival among the three groups. In the NBNC-HCC group, multiple intrahepatic or distant recurrences (25 %) were significantly higher than in the C-HCC group (17 %), and the rate of recurrence more than 2 years after hepatic resection (24 %) was significantly higher than that of the B-HCC group (12 %).
Conclusions
The surgical outcomes of patients with NBNC-HCC were not significantly different compared with those of the patients with B-HCC or C-HCC. There was a substantial population with late recurrence among the patients with NBNC-HCC after curative hepatic resection, and thus not only long-term follow-up but also the early establishment of preventive methods for HCC recurrence from NBNC-hepatitis are necessary.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25472646</pmid><doi>10.1245/s10434-014-4261-x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2015-07, Vol.22 (7), p.2279-2285 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Aged Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - surgery Carcinoma, Hepatocellular - virology Female Follow-Up Studies Hepatectomy - mortality Hepatitis B Surface Antigens - blood Hepatitis B virus Hepatitis C Antibodies - blood Hepatitis C virus Hepatobiliary Tumors Humans Liver Neoplasms - blood Liver Neoplasms - mortality Liver Neoplasms - surgery Liver Neoplasms - virology Male Medicine Medicine & Public Health Middle Aged Neoplasm Staging Oncology Prognosis Retrospective Studies Surgery Surgical Oncology Survival Rate |
| title | Surgical Outcomes of Hepatic Resection for Hepatitis B Virus Surface Antigen-Negative and Hepatitis C Virus Antibody-Negative Hepatocellular Carcinoma |
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