Brief Report: Autocrine Cytokine–Mediated Deficiency of TRAIL‐Induced Monocyte Apoptosis in Rheumatoid Arthritis

Objective Dysregulated apoptosis of monocytes is a pathogenic feature of rheumatoid arthritis (RA). The aim of this study was to investigate the role of TRAIL and TRAIL‐induced apoptosis in patients with RA. Methods Cell surface expression and serum concentrations of TRAIL were determined in 63 pati...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2015-07, Vol.67 (7), p.1760-1765
Hauptverfasser:	Meusch, Undine, Klingner, Maria, Mathar, Christoph, Malysheva, Olga, Baerwald, Christoph, Rossol, Manuela, Wagner, Ulf
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis - physiology Arthritis, Rheumatoid - pathology Arthritis, Rheumatoid - physiopathology Autocrine Communication - physiology Case-Control Studies Cells, Cultured Humans Interleukin-8 - metabolism Middle Aged Mitogen-Activated Protein Kinase 1 - physiology Mitogen-Activated Protein Kinase 3 - physiology Monocytes - pathology Monocytes - physiology p38 Mitogen-Activated Protein Kinases - physiology Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Rheumatoid arthritis Signal Transduction - physiology Studies TNF-Related Apoptosis-Inducing Ligand - pharmacology TNF-Related Apoptosis-Inducing Ligand - physiology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor necrosis factor-TNF
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