Hirulog effect in rat endotoxin shock

Hirulog TM is a thrombin catalytic site inhibitor which exhibits specificity for the anionic binding exosite of alpha thrombin. Here, we have evaluated the effect of Hirulog TM (1, 5 and 10 mg/kg, 30 min pretreatment) in a rat model of endotoxemia. Intravenous injection of lipopolysaccharide from E....

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Veröffentlicht in:	Life sciences (1973) 1995, Vol.57 (20), p.PL307-PL313
Hauptverfasser:	Cicala, C., Bucci, M.R., Maraganore, J.M., Cirino, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antithrombins - pharmacology endotoxin shock Evaluation Studies as Topic Fibrinogen - drug effects Fibrinogen - metabolism Hirudins - analogs & derivatives Hirudins - pharmacology Hirulog TM Hypotension - chemically induced Hypotension - drug therapy leukopenia Leukopenia - chemically induced Leukopenia - drug therapy Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - toxicity Male mortality Peptide Fragments - pharmacology Rats Rats, Wistar Recombinant Proteins - pharmacology Shock, Septic - blood Shock, Septic - drug therapy thrombin Thrombin - antagonists & inhibitors thrombocytopenia Thrombocytopenia - chemically induced Thrombocytopenia - drug therapy Toxemia - blood
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