Diagnostic accuracy of (18)F-FDG PET/CT compared with that of contrast-enhanced MRI of the breast at 3 T
To compare the diagnostic accuracy of prone (18)F-FDG PET/CT with that of contrast-enhanced MRI (CE-MRI) at 3 T in suspicious breast lesions. To evaluate the influence of tumour size on diagnostic accuracy and the use of maximum standardized uptake value (SUVMAX) thresholds to differentiate malignan...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2015-10, Vol.42 (11), p.1656-1665 |
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| container_title | European journal of nuclear medicine and molecular imaging |
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| creator | Magometschnigg, Heinrich F Baltzer, Pascal A Fueger, Barbara Helbich, Thomas H Karanikas, Georgios Dubsky, Peter Rudas, Margaretha Weber, Michael Pinker, Katja |
| description | To compare the diagnostic accuracy of prone (18)F-FDG PET/CT with that of contrast-enhanced MRI (CE-MRI) at 3 T in suspicious breast lesions. To evaluate the influence of tumour size on diagnostic accuracy and the use of maximum standardized uptake value (SUVMAX) thresholds to differentiate malignant from benign breast lesions.
A total of 172 consecutive patients with an imaging abnormality were included in this IRB-approved prospective study. All patients underwent (18)F-FDG PET/CT and CE-MRI of the breast at 3 T in the prone position. Two reader teams independently evaluated the likelihood of malignancy as determined by (18)F-FDG PET/CT and CE-MRI independently. (18)F-FDG PET/CT data were qualitatively evaluated by visual interpretation. Quantitative assessment was performed by calculation of SUVMAX. Sensitivity, specificity, diagnostic accuracy, area under the curve and interreader agreement were calculated for all lesions and for lesions |
| doi_str_mv | 10.1007/s00259-015-3099-1 |
| format | Article |
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A total of 172 consecutive patients with an imaging abnormality were included in this IRB-approved prospective study. All patients underwent (18)F-FDG PET/CT and CE-MRI of the breast at 3 T in the prone position. Two reader teams independently evaluated the likelihood of malignancy as determined by (18)F-FDG PET/CT and CE-MRI independently. (18)F-FDG PET/CT data were qualitatively evaluated by visual interpretation. Quantitative assessment was performed by calculation of SUVMAX. Sensitivity, specificity, diagnostic accuracy, area under the curve and interreader agreement were calculated for all lesions and for lesions <10 mm. Histopathology was used as the standard of reference.
There were 132 malignant and 40 benign lesions; 23 lesions (13.4%) were <10 mm. Both (18)F-FDG PET/CT and CE-MRI achieved an overall diagnostic accuracy of 93%. There were no significant differences in sensitivity (p = 0.125), specificity (p = 0.344) or diagnostic accuracy (p = 1). For lesions <10 mm, diagnostic accuracy deteriorated to 91% with both (18)F-FDG PET/CT and CE-MRI. Although no significant difference was found for lesions <10 mm, CE-MRI at 3 T seemed to be more sensitive but less specific than (18)F-FDG PET/CT. Interreader agreement was excellent (κ = 0.85 and κ = 0.92). SUVMAX threshold was not helpful in differentiating benign from malignant lesions.
(18)F-FDG PET/CT and CE-MRI at 3 T showed equal diagnostic accuracies in breast cancer diagnosis. For lesions <10 mm, diagnostic accuracy deteriorated, but was equal for (18)F-FDG PET/CT and CE-MRI at 3 T. For lesions <10 mm, CE-MRI at 3 T seemed to be more sensitive but less specific than (18)F-FDG PET/CT. Quantitative assessment using an SUVMAX threshold for differentiating benign from malignant lesions was not helpful in breast cancer diagnosis.]]></description><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-015-3099-1</identifier><identifier>PMID: 26121928</identifier><language>eng</language><publisher>Germany</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Breast - diagnostic imaging ; Breast Neoplasms - diagnostic imaging ; Contrast Media ; Diagnosis, Differential ; Female ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Multimodal Imaging ; Positron-Emission Tomography ; ROC Curve ; Tomography, X-Ray Computed ; Young Adult</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2015-10, Vol.42 (11), p.1656-1665</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26121928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Magometschnigg, Heinrich F</creatorcontrib><creatorcontrib>Baltzer, Pascal A</creatorcontrib><creatorcontrib>Fueger, Barbara</creatorcontrib><creatorcontrib>Helbich, Thomas H</creatorcontrib><creatorcontrib>Karanikas, Georgios</creatorcontrib><creatorcontrib>Dubsky, Peter</creatorcontrib><creatorcontrib>Rudas, Margaretha</creatorcontrib><creatorcontrib>Weber, Michael</creatorcontrib><creatorcontrib>Pinker, Katja</creatorcontrib><title>Diagnostic accuracy of (18)F-FDG PET/CT compared with that of contrast-enhanced MRI of the breast at 3 T</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description><![CDATA[To compare the diagnostic accuracy of prone (18)F-FDG PET/CT with that of contrast-enhanced MRI (CE-MRI) at 3 T in suspicious breast lesions. To evaluate the influence of tumour size on diagnostic accuracy and the use of maximum standardized uptake value (SUVMAX) thresholds to differentiate malignant from benign breast lesions.
A total of 172 consecutive patients with an imaging abnormality were included in this IRB-approved prospective study. All patients underwent (18)F-FDG PET/CT and CE-MRI of the breast at 3 T in the prone position. Two reader teams independently evaluated the likelihood of malignancy as determined by (18)F-FDG PET/CT and CE-MRI independently. (18)F-FDG PET/CT data were qualitatively evaluated by visual interpretation. Quantitative assessment was performed by calculation of SUVMAX. Sensitivity, specificity, diagnostic accuracy, area under the curve and interreader agreement were calculated for all lesions and for lesions <10 mm. Histopathology was used as the standard of reference.
There were 132 malignant and 40 benign lesions; 23 lesions (13.4%) were <10 mm. Both (18)F-FDG PET/CT and CE-MRI achieved an overall diagnostic accuracy of 93%. There were no significant differences in sensitivity (p = 0.125), specificity (p = 0.344) or diagnostic accuracy (p = 1). For lesions <10 mm, diagnostic accuracy deteriorated to 91% with both (18)F-FDG PET/CT and CE-MRI. Although no significant difference was found for lesions <10 mm, CE-MRI at 3 T seemed to be more sensitive but less specific than (18)F-FDG PET/CT. Interreader agreement was excellent (κ = 0.85 and κ = 0.92). SUVMAX threshold was not helpful in differentiating benign from malignant lesions.
(18)F-FDG PET/CT and CE-MRI at 3 T showed equal diagnostic accuracies in breast cancer diagnosis. For lesions <10 mm, diagnostic accuracy deteriorated, but was equal for (18)F-FDG PET/CT and CE-MRI at 3 T. For lesions <10 mm, CE-MRI at 3 T seemed to be more sensitive but less specific than (18)F-FDG PET/CT. Quantitative assessment using an SUVMAX threshold for differentiating benign from malignant lesions was not helpful in breast cancer diagnosis.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Breast - diagnostic imaging</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Contrast Media</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Positron-Emission Tomography</subject><subject>ROC Curve</subject><subject>Tomography, X-Ray Computed</subject><subject>Young Adult</subject><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMlOwzAURS0kREvhA9ggL8vC9HnI4CXqRKUiEArr6MVxSFAzEDtC_XtSUVZ3cY7u4hByx-GRA0QLByACzYAHTILWjF-QKQ-5ZhHEekKunfsC4LGI9RWZiJALrkU8JeWqws-mdb4yFI0ZejRH2hZ0zuOHDdustvRtnSyWCTVt3WFvc_pT-ZL6Ev1JM23je3Se2abExoz45X13Ar60NOvtiOhoSprckMsCD87enndGPjbrZPnM9q_b3fJpzzouQs8wFkpCAUJYLo3SmcpzGRvB80LrMEIb8QJUGGDEM5BKYaDQ6iAoNGaFsUrOyPzvt-vb78E6n9aVM_ZwwMa2g0v5qQdIiMNRvT-rQ1bbPO36qsb-mP7Xkb8gnGJO</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Magometschnigg, Heinrich F</creator><creator>Baltzer, Pascal A</creator><creator>Fueger, Barbara</creator><creator>Helbich, Thomas H</creator><creator>Karanikas, Georgios</creator><creator>Dubsky, Peter</creator><creator>Rudas, Margaretha</creator><creator>Weber, Michael</creator><creator>Pinker, Katja</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201510</creationdate><title>Diagnostic accuracy of (18)F-FDG PET/CT compared with that of contrast-enhanced MRI of the breast at 3 T</title><author>Magometschnigg, Heinrich F ; Baltzer, Pascal A ; Fueger, Barbara ; Helbich, Thomas H ; Karanikas, Georgios ; Dubsky, Peter ; Rudas, Margaretha ; Weber, Michael ; Pinker, Katja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-a82430f022e13c49b4dd38c21df9967ae71f0465a71b0344a54ae955f9abfce43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Breast - diagnostic imaging</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Contrast Media</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Positron-Emission Tomography</topic><topic>ROC Curve</topic><topic>Tomography, X-Ray Computed</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magometschnigg, Heinrich F</creatorcontrib><creatorcontrib>Baltzer, Pascal A</creatorcontrib><creatorcontrib>Fueger, Barbara</creatorcontrib><creatorcontrib>Helbich, Thomas H</creatorcontrib><creatorcontrib>Karanikas, Georgios</creatorcontrib><creatorcontrib>Dubsky, Peter</creatorcontrib><creatorcontrib>Rudas, Margaretha</creatorcontrib><creatorcontrib>Weber, Michael</creatorcontrib><creatorcontrib>Pinker, Katja</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magometschnigg, Heinrich F</au><au>Baltzer, Pascal A</au><au>Fueger, Barbara</au><au>Helbich, Thomas H</au><au>Karanikas, Georgios</au><au>Dubsky, Peter</au><au>Rudas, Margaretha</au><au>Weber, Michael</au><au>Pinker, Katja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic accuracy of (18)F-FDG PET/CT compared with that of contrast-enhanced MRI of the breast at 3 T</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2015-10</date><risdate>2015</risdate><volume>42</volume><issue>11</issue><spage>1656</spage><epage>1665</epage><pages>1656-1665</pages><eissn>1619-7089</eissn><abstract><![CDATA[To compare the diagnostic accuracy of prone (18)F-FDG PET/CT with that of contrast-enhanced MRI (CE-MRI) at 3 T in suspicious breast lesions. To evaluate the influence of tumour size on diagnostic accuracy and the use of maximum standardized uptake value (SUVMAX) thresholds to differentiate malignant from benign breast lesions.
A total of 172 consecutive patients with an imaging abnormality were included in this IRB-approved prospective study. All patients underwent (18)F-FDG PET/CT and CE-MRI of the breast at 3 T in the prone position. Two reader teams independently evaluated the likelihood of malignancy as determined by (18)F-FDG PET/CT and CE-MRI independently. (18)F-FDG PET/CT data were qualitatively evaluated by visual interpretation. Quantitative assessment was performed by calculation of SUVMAX. Sensitivity, specificity, diagnostic accuracy, area under the curve and interreader agreement were calculated for all lesions and for lesions <10 mm. Histopathology was used as the standard of reference.
There were 132 malignant and 40 benign lesions; 23 lesions (13.4%) were <10 mm. Both (18)F-FDG PET/CT and CE-MRI achieved an overall diagnostic accuracy of 93%. There were no significant differences in sensitivity (p = 0.125), specificity (p = 0.344) or diagnostic accuracy (p = 1). For lesions <10 mm, diagnostic accuracy deteriorated to 91% with both (18)F-FDG PET/CT and CE-MRI. Although no significant difference was found for lesions <10 mm, CE-MRI at 3 T seemed to be more sensitive but less specific than (18)F-FDG PET/CT. Interreader agreement was excellent (κ = 0.85 and κ = 0.92). SUVMAX threshold was not helpful in differentiating benign from malignant lesions.
(18)F-FDG PET/CT and CE-MRI at 3 T showed equal diagnostic accuracies in breast cancer diagnosis. For lesions <10 mm, diagnostic accuracy deteriorated, but was equal for (18)F-FDG PET/CT and CE-MRI at 3 T. For lesions <10 mm, CE-MRI at 3 T seemed to be more sensitive but less specific than (18)F-FDG PET/CT. Quantitative assessment using an SUVMAX threshold for differentiating benign from malignant lesions was not helpful in breast cancer diagnosis.]]></abstract><cop>Germany</cop><pmid>26121928</pmid><doi>10.1007/s00259-015-3099-1</doi><tpages>10</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Breast - diagnostic imaging Breast Neoplasms - diagnostic imaging Contrast Media Diagnosis, Differential Female Fluorodeoxyglucose F18 Humans Magnetic Resonance Imaging Middle Aged Multimodal Imaging Positron-Emission Tomography ROC Curve Tomography, X-Ray Computed Young Adult |
| title | Diagnostic accuracy of (18)F-FDG PET/CT compared with that of contrast-enhanced MRI of the breast at 3 T |
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