The role of TP53 in miRNA loading onto AGO2 and in remodelling the miRNA–mRNA interaction network

Abstract Background DNA damage transactivates tumour protein p53 (TP53) -regulated surveillance, crucial in suppressing tumorigenesis. TP53 mediates this process directly by transcriptionally modulating gene and microRNA (miRNA) expression and indirectly by regulating miRNA biogenesis. However, the...

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Veröffentlicht in:	The Lancet (British edition) 2015-02, Vol.385, p.S15-S15
Hauptverfasser:	Krell, Jonathan, Dr, Stebbing, Justin, PhD, Frampton, Adam Enver, PhD, Carissimi, Claudia, PhD, Harding, Victoria, MRCP, De Giorgio, Alexander, MA, Fulci, Valerio, PhD, Macino, Giuseppe, PhD, Colombo, Teresa, PhD, Castellano, Leandro, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis Deoxyribonucleic acid DNA Internal Medicine Medical research
Online-Zugang:	Volltext
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