The use of in situ near infrared imaging and Raman mapping to study the disproportionation of a drug HCl salt during dissolution

[Display omitted] NIR imaging and Raman mapping of the dissolution of model pharmaceutical formulations containing the HCl salt of a developmental compound, were carried out using a custom designed flow through cell. The results of this work have shown that NIR imaging and Raman mapping are capable...

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Veröffentlicht in:	International journal of pharmaceutics 2015-09, Vol.493 (1-2), p.198-207
Hauptverfasser:	Wray, Patrick S., Sinclair, Wayne E., Jones, John W., Clarke, Graham S., Both, Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellulose - chemistry Disproportionation Dissolution Hydrochloric Acid - chemistry NIR imaging Pharmaceutical Preparations - chemistry Raman mapping Salts Solubility Spectroscopy, Near-Infrared Spectrum Analysis, Raman Tablets
Online-Zugang:	Volltext
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