Calculation of injection forces for highly concentrated protein solutions

[Display omitted] Protein solutions often manifest a high viscosity at high solution concentrations, thus impairing injectability. Accordingly, accurate prediction of the injection force based on solution viscosity can greatly support protein formulation and device development. In this study, the sh...

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Veröffentlicht in:	International journal of pharmaceutics 2015-09, Vol.493 (1-2), p.70-74
Hauptverfasser:	Fischer, Ingo, Schmidt, Astrid, Bryant, Andrew, Besheer, Ahmed
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry, Pharmaceutical High concentration protein solution Injectability Injection force Injections Mechanical Phenomena Models, Theoretical Needles Proteins - chemistry Rheology Solutions - chemistry Tomography, X-Ray Computed Viscosity
Online-Zugang:	Volltext
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