ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling

Abstract Rationale Pressure overload induces adaptive remodeling processes in the heart. However, when pressure overload persists, adaptive changes turn into maladaptive alterations leading to cardiac hypertrophy and heart failure. ATF3 is a stress inducible transcription factor that is transiently...

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Veröffentlicht in:	International journal of cardiology 2015-11, Vol.198, p.232-240
Hauptverfasser:	Koren, L, Alishekevitz, D, Elhanani, O, Nevelsky, A, Hai, T, Kehat, I, Shaked, Y, Aronheim, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - biosynthesis Activating Transcription Factor 3 - deficiency Animals Bone marrow transplantation Cardiac hypertrophy Cardiac remodeling Cardiomegaly - metabolism Cardiomegaly - pathology Cardiovascular Macrophages Macrophages - metabolism Macrophages - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Pressure overload Ventricular Remodeling - physiology
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