Serum and tissue pharmacokinetics of silibinin after per os and i.v. administration to mice as a HP-β-CD lyophilized product

Silibinin, the main active component of Silybum marianum is a hepatoprotective and antioxidant agent with antitumor effect, exhibiting very low aqueous solubility and oral bioavailability limiting its use in therapeutics. We characterized serum and tissue pharmacokinetics of SLB, calculated its abso...

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Veröffentlicht in:	International journal of pharmaceutics 2015-09, Vol.493 (1-2), p.366-373
Hauptverfasser:	Christodoulou, Eirini, Kechagia, Irene-Ariadne, Tzimas, Stavros, Balafas, Evangelos, Kostomitsopoulos, Nikolaos, Archontaki, Helen, Dokoumetzidis, Aristides, Valsami, Georgia
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin Administration, Intravenous Administration, Oral Animals Antioxidants - administration & dosage Antioxidants - chemistry Antioxidants - pharmacokinetics beta-Cyclodextrins - chemistry Biological Availability Freeze Drying HP-β-CD Lyophilization Male Mice, Inbred C57BL Models, Biological PBPK model Serum/tissue pharmacokinetics Silibinin Silymarin - administration & dosage Silymarin - blood Silymarin - chemistry Silymarin - pharmacokinetics Tissue Distribution
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