Using the local immune response from the natural buffalo host to generate an antibody fragment library that binds the early larval stages of Schistosoma japonicum

[Display omitted] •Use of a natural host (Bubalus bubalis) of Schistosoma japonicum to study antibody–antigen interactions.•Expression of B. bubalis B-cell heavy and light chain variable region (VH, VL) repertoire on the phage particle surface.•Longer single-chain antibody Fv domain (scFv)-associate...

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Veröffentlicht in:	International journal for parasitology 2015-09, Vol.45 (11), p.729-740
Hauptverfasser:	Hosking, Christopher G., Driguez, Patrick, McWilliam, Hamish E.G., Ilag, Leodevico L., Gladman, Simon, Li, Yuesheng, Piedrafita, David, McManus, Donald P., Meeusen, Els N.T., de Veer, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Helminth - immunology Antibodies, Helminth - isolation & purification Antigens, Helminth - immunology Buffalo Buffaloes China Larva - growth & development Larva - immunology Lymph Nodes - immunology Phage-display Protein Array Analysis Protein microarray scFv Schistosoma japonicum Schistosoma japonicum - growth & development Schistosoma japonicum - immunology Schistosomiasis japonica - immunology Schistosomiasis japonica - veterinary Schistosomule Single-Chain Antibodies - immunology Single-Chain Antibodies - isolation & purification Single-chain Fv antibody
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