Formulation and process factors influencing product quality and in vitro performance of ophthalmic ointments

[Display omitted] Owing to its unique anatomical and physiological functions, ocular surface presents special challenges for both design and performance evaluation of the ophthalmic ointment drug products formulated with a variety of bases. The current investigation was carried out to understand and...

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Veröffentlicht in:	International journal of pharmaceutics 2015-09, Vol.493 (1-2), p.412-425
Hauptverfasser:	Xu, Xiaoming, Al-Ghabeish, Manar, Rahman, Ziyaur, Krishnaiah, Yellela S.R., Yerlikaya, Firat, Yang, Yang, Manda, Prashanth, Hunt, Robert L., Khan, Mansoor A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir Acyclovir - administration & dosage Acyclovir - chemistry Administration, Ophthalmic Animals Antiviral Agents - administration & dosage Antiviral Agents - chemistry Chemistry, Pharmaceutical Cornea - metabolism Corneal drug permeation Design of experiments (DoE) Drug Compounding Drug Liberation Equivalence evaluation In vitro release testing Male Multivariate analysis Ointments Ophthalmic ointments Particle Size Permeability Quality Control Rabbits Rheology Viscosity Yield stress
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