Genotyping and immunohistochemistry of gastrointestinal stromal tumors: An update

Abstract Gastrointestinal stromal tumors (GISTs) were originally thought to harbor either KIT or platelet-derived growth factor receptor A ( PDGFRA) mutations only. However, more recent discoveries have highlighted additional, less common oncogenic driver mutations including NF1 , BRAF , and succina...

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Veröffentlicht in:	Seminars in diagnostic pathology 2015-09, Vol.32 (5), p.392-399
Hauptverfasser:	Rubin, Brian P., MD, PhD, Heinrich, Michael C., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics BRAF Gastrointestinal Neoplasms - chemistry Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - pathology Gastrointestinal Stromal Tumors - chemistry Gastrointestinal Stromal Tumors - genetics Gastrointestinal Stromal Tumors - pathology Genetic Predisposition to Disease GIST Humans Immunohistochemistry Molecular Diagnostic Techniques Mutation Neoplasm Proteins - genetics NF1 Pathology Phenotype Platelet-derived growth factor receptor A Predictive Value of Tests Prognosis Succinate Dehydrogenase
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