Thrombin inhibits the anti-myeloperoxidase and ferroxidase functions of ceruloplasmin: relevance in rheumatoid arthritis

Human ceruloplasmin (CP) is a multifunctional copper-binding protein produced in the liver. CP oxidizes Fe2+ to Fe3+, decreasing the concentration of Fe2+ available for generating harmful oxidant species. CP is also a potent inhibitor of leukocyte myeloperoxidase (MPO) (Kd=130nM), a major source of...

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Veröffentlicht in:	Free radical biology & medicine 2015-09, Vol.86, p.279-294
Hauptverfasser:	Sokolov, Alexej V., Acquasaliente, Laura, Kostevich, Valeria A., Frasson, Roberta, Zakharova, Elena T., Pontarollo, Giulia, Vasilyev, Vadim B., De Filippis, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Arthritis, Rheumatoid - enzymology Case-Control Studies Ceruloplasmin Ceruloplasmin - chemistry Ceruloplasmin - physiology Female Humans Male Middle Aged Models, Molecular Myeloperoxidase Oxidants Peroxidase - chemistry Peroxidase - physiology Protein Interaction Domains and Motifs Protein–protein interaction Proteolysis Rheumatoid arthritis Surface plasmon resonance Thrombin Thrombin - chemistry Thrombin - physiology
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