The N-terminal domain of Npro of classical swine fever virus determines its stability and regulates type I IFN production

The viral protein Npro is unique to the genus Pestivirus within the family Flaviviridae. After autocatalytic cleavage from the nascent polyprotein, Npro suppresses type I IFN (IFN-α/β) induction by mediating proteasomal degradation of IFN regulatory factor 3 (IRF-3). Previous studies found that the...

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Veröffentlicht in:	Journal of general virology 2015-07, Vol.96 (Pt 7), p.1746-1756
Hauptverfasser:	Mine, Junki, Tamura, Tomokazu, Mitsuhashi, Kazuya, Okamatsu, Masatoshi, Parchariyanon, Sujira, Pinyochon, Wasana, Ruggli, Nicolas, Tratschin, Jon-Duri, Kida, Hiroshi, Sakoda, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Classical Swine Fever - virology Classical swine fever virus - genetics Classical swine fever virus - immunology Classical swine fever virus - isolation & purification DNA Mutational Analysis Down-Regulation Endopeptidases - chemistry Endopeptidases - genetics Endopeptidases - immunology Host-Pathogen Interactions Interferon Regulatory Factors - antagonists & inhibitors Interferon Type I - antagonists & inhibitors Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - immunology Mutation, Missense Protein Binding Protein Interaction Mapping Protein Stability Protein Structure, Tertiary Swine Thailand Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - immunology
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