Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3

Signal transducers and activators of transcription 3 (STAT3) is a transcription factor that is aberrantly activated in many cancer cells. Constitutively activated STAT3 is oncogenic, presumably as a consequence of the genes that it differentially regulates. Activated STAT3 correlated with elevated c...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-03, Vol.66 (5), p.2544-2552
Hauptverfasser:	LESLIE, Kenneth, LANG, Cynthia, SAKAMAKI, Toshiyuki, PESTELL, Richard, BROMBERG, Jacqueline, DEVGAN, Geeta, AZARE, Janeen, BERISHAJ, Marjan, GERALD, William, YOUNG BAE KIM, PAZ, Keren, DARNELL, James E, ALBANESE, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Binding Sites Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Adhesion - genetics Cell Growth Processes - genetics Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cyclin D1 - biosynthesis Cyclin D1 - genetics G1 Phase - genetics Humans Luciferases - genetics Luciferases - metabolism Medical sciences Mice Mutagenesis, Site-Directed NIH 3T3 Cells Papillomavirus E7 Proteins - genetics Pharmacology. Drug treatments Promoter Regions, Genetic Rats RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Small Interfering - genetics STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Transcriptional Activation Tumors
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