Identification of an Interferon-γ Receptor α Chain Sequence Required for JAK-1 Binding (∗)

We have shown previously that a four-amino acid block residing at positions 266-269 (LPKS) in the intracellular domain of the human interferon-γ (IFN-γ) receptor α chain is critical for IFN-γ-dependent tyrosine kinase activation and biologic response induction. Herein we show that this sequence is r...

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Veröffentlicht in:	The Journal of biological chemistry 1996-01, Vol.271 (1), p.9-12
Hauptverfasser:	Kaplan, Daniel H., Greenlund, Andrew C., Tanner, J. William, Shaw, Andrey S., Schreiber, Robert D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, CD - chemistry Antigens, CD - metabolism Humans Interferon gamma Receptor Janus Kinase 1 Mice Molecular Sequence Data Proline - chemistry Proline - metabolism Protein Binding Protein-Tyrosine Kinases - metabolism Receptors, Interferon - chemistry Receptors, Interferon - metabolism Tumor Cells, Cultured
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