Nitric Oxide and Reactive Oxygen Species Production Causes Progressive Damage in Rats after Cessation of Silica Inhalation

Our laboratory has previously reported results from a rat silica inhalation study which determined that, even after silica exposure ended, pulmonary inflammation and damage progressed with subsequent fibrosis development. In the present study, the relationship between silica exposure, nitric oxide (...

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Veröffentlicht in:	Toxicological sciences 2006-03, Vol.90 (1), p.188-197
Hauptverfasser:	Porter, Dale W., Millecchia, Lyndell L., Willard, Patsy, Robinson, Victor A., Ramsey, Dawn, McLaurin, Jeffery, Khan, Amir, Brumbaugh, Kurt, Beighley, Christoper M., Teass, Alexander, Castranova, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Air Pollutants, Occupational - toxicity Animals Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Disease Models, Animal Inhalation Exposure Lung - drug effects Lung - enzymology Lung - pathology Macrophages, Alveolar - drug effects Macrophages, Alveolar - enzymology Macrophages, Alveolar - pathology Male nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism oxidative stress rat Rats Rats, Inbred F344 reactive oxygen species Reactive Oxygen Species - metabolism silica inhalation Silicon Dioxide - toxicity Silicosis - etiology Silicosis - metabolism Silicosis - pathology Specific Pathogen-Free Organisms Time Factors
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