HER-2/neu Represses the Metastasis Suppressor RECK via ERK and Sp Transcription Factors to Promote Cell Invasion

Matrix metalloproteinase (MMP) inhibitory proteins may negatively regulate MMP activity to suppress tumor metastasis. In this study, we demonstrate that the HER-2/neu oncogene inhibits the expression of the MMP inhibitor RECK to promote cell invasion. RECK was inhibited via transcriptional repressio...

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Veröffentlicht in:	The Journal of biological chemistry 2006-02, Vol.281 (8), p.4718-4725
Hauptverfasser:	Hsu, Ming-Chuan, Chang, Hui-Chiu, Hung, Wen-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Blotting, Western Cell Line, Tumor Cell Nucleus - metabolism Chromatin Immunoprecipitation DNA - metabolism DNA, Complementary - metabolism Down-Regulation Extracellular Signal-Regulated MAP Kinases - metabolism Gene Deletion Gene Expression Regulation, Neoplastic Genetic Vectors GPI-Linked Proteins Histone Deacetylase Inhibitors Humans Hydroxamic Acids - pharmacology Immunoprecipitation Matrix Metalloproteinase 9 - metabolism Membrane Glycoproteins - metabolism Mice Neoplasm Invasiveness Neoplasm Metastasis NIH 3T3 Cells Promoter Regions, Genetic Protein Binding Protein Biosynthesis Receptor, ErbB-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Sp1 Transcription Factor - metabolism Sp3 Transcription Factor - metabolism Threonine - chemistry Transcription, Genetic Transfection Up-Regulation
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