Chronic renal failure rats are highly sensitive to aristolochic acids, which are nephrotoxic and carcinogenic agents

Aristolochic acid (AA), a component of some Chinese herbal medicines, may cause Chinese Herbs Nephropathy (CHN) and multi-systemic tumors by the formation of AA–DNA adducts. In this study, we established an animal model to further characterize the mechanisms of AA-induced diseases. Our results indic...

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Veröffentlicht in:	Cancer letters 2006-02, Vol.232 (2), p.236-242
Hauptverfasser:	Cheng, Chen-Li, Chen, Kuo-Jung, Shih, Po-Hung, Lu, Lieng-Yi, Hung, Chia-Fang, Lin, Wen-Ching, Yesong Gu, Jason
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aristolochic acid Aristolochic Acids - toxicity Chronic renal failure Creatinine - blood Deoxyribonucleic acid DNA DNA Adducts - analysis DNA repair Genes Genes, ras Kidney - drug effects Kidney Failure, Chronic - genetics Kidney Failure, Chronic - physiopathology Mutation Neoplasms - chemically induced Point Mutation ras proto-oncogene Rats Rats, Wistar RFLP Rodents Tumors
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