Chronic renal failure rats are highly sensitive to aristolochic acids, which are nephrotoxic and carcinogenic agents
Aristolochic acid (AA), a component of some Chinese herbal medicines, may cause Chinese Herbs Nephropathy (CHN) and multi-systemic tumors by the formation of AA–DNA adducts. In this study, we established an animal model to further characterize the mechanisms of AA-induced diseases. Our results indic...
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| Veröffentlicht in: | Cancer letters 2006-02, Vol.232 (2), p.236-242 |
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| container_title | Cancer letters |
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| creator | Cheng, Chen-Li Chen, Kuo-Jung Shih, Po-Hung Lu, Lieng-Yi Hung, Chia-Fang Lin, Wen-Ching Yesong Gu, Jason |
| description | Aristolochic acid (AA), a component of some Chinese herbal medicines, may cause Chinese Herbs Nephropathy (CHN) and multi-systemic tumors by the formation of AA–DNA adducts. In this study, we established an animal model to further characterize the mechanisms of AA-induced diseases. Our results indicated that AA significantly inhibited rat growth in terms of weight gain. By measuring the serum creatinine levels, AA resulted in considerable damage to the rat renal system, not only for those in which chronic renal failure (CRF) was induced but also for normal healthy rats. Mutation-specific polymerase chain reaction (PCR) and XbaI restriction fragment length polymorphism (RFLP) revealed the CAA→CTA transversion mutation at codon 61 of the H-
ras proto-oncogene from the stomach tissues of CRF rats fed with AA, but not from other tissues of rats in the same experimental group. In addition, no such mutations were found in the tissues of CRF rats without AA treatment or healthy rats fed with AA. Our results strongly demonstrated that AA was in fact nephrotoxic and carcinogenic, especially to those CRF rats. |
| doi_str_mv | 10.1016/j.canlet.2005.02.021 |
| format | Article |
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ras proto-oncogene from the stomach tissues of CRF rats fed with AA, but not from other tissues of rats in the same experimental group. In addition, no such mutations were found in the tissues of CRF rats without AA treatment or healthy rats fed with AA. Our results strongly demonstrated that AA was in fact nephrotoxic and carcinogenic, especially to those CRF rats.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2005.02.021</identifier><identifier>PMID: 16458120</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Aristolochic acid ; Aristolochic Acids - toxicity ; Chronic renal failure ; Creatinine - blood ; Deoxyribonucleic acid ; DNA ; DNA Adducts - analysis ; DNA repair ; Genes ; Genes, ras ; Kidney - drug effects ; Kidney Failure, Chronic - genetics ; Kidney Failure, Chronic - physiopathology ; Mutation ; Neoplasms - chemically induced ; Point Mutation ; ras proto-oncogene ; Rats ; Rats, Wistar ; RFLP ; Rodents ; Tumors</subject><ispartof>Cancer letters, 2006-02, Vol.232 (2), p.236-242</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Feb 8, 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-48da28b98539f796e9e7c86b067542c9f580bc1dbaf18a2daf505f7c641797323</citedby><cites>FETCH-LOGICAL-c419t-48da28b98539f796e9e7c86b067542c9f580bc1dbaf18a2daf505f7c641797323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2005.02.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16458120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Chen-Li</creatorcontrib><creatorcontrib>Chen, Kuo-Jung</creatorcontrib><creatorcontrib>Shih, Po-Hung</creatorcontrib><creatorcontrib>Lu, Lieng-Yi</creatorcontrib><creatorcontrib>Hung, Chia-Fang</creatorcontrib><creatorcontrib>Lin, Wen-Ching</creatorcontrib><creatorcontrib>Yesong Gu, Jason</creatorcontrib><title>Chronic renal failure rats are highly sensitive to aristolochic acids, which are nephrotoxic and carcinogenic agents</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Aristolochic acid (AA), a component of some Chinese herbal medicines, may cause Chinese Herbs Nephropathy (CHN) and multi-systemic tumors by the formation of AA–DNA adducts. In this study, we established an animal model to further characterize the mechanisms of AA-induced diseases. Our results indicated that AA significantly inhibited rat growth in terms of weight gain. By measuring the serum creatinine levels, AA resulted in considerable damage to the rat renal system, not only for those in which chronic renal failure (CRF) was induced but also for normal healthy rats. Mutation-specific polymerase chain reaction (PCR) and XbaI restriction fragment length polymorphism (RFLP) revealed the CAA→CTA transversion mutation at codon 61 of the H-
ras proto-oncogene from the stomach tissues of CRF rats fed with AA, but not from other tissues of rats in the same experimental group. In addition, no such mutations were found in the tissues of CRF rats without AA treatment or healthy rats fed with AA. Our results strongly demonstrated that AA was in fact nephrotoxic and carcinogenic, especially to those CRF rats.</description><subject>Animals</subject><subject>Aristolochic acid</subject><subject>Aristolochic Acids - toxicity</subject><subject>Chronic renal failure</subject><subject>Creatinine - blood</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Adducts - analysis</subject><subject>DNA repair</subject><subject>Genes</subject><subject>Genes, ras</subject><subject>Kidney - drug effects</subject><subject>Kidney Failure, Chronic - genetics</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Mutation</subject><subject>Neoplasms - chemically induced</subject><subject>Point Mutation</subject><subject>ras proto-oncogene</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RFLP</subject><subject>Rodents</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVtr3DAQhUVpaDZp_0EphkKe4q0kW5b0UghLbrCQl_RZyPJ4rcUrbSU5l38fubtQyENgYAbpO2dgDkLfCV4STJpf26XRboS0pBizJaa5yCe0IILTkkuBP6MFrnBdVqJip-gsxi3OYM3ZF3RKmpoJQvECpdUQvLOmCOD0WPTajlOAIugUC52HwW6G8bWI4KJN9gmK5PO7jcmP3gxZp43t4mXxnOfhn8LBPlsm_zJ_uq4wOhjr_AbmLTq3FL-ik16PEb4d-zn6c3P9uLor1w-396urdWlqIlNZi05T0UrBKtlz2YAEbkTT4oazmhrZM4FbQ7pW90Ro2umeYdZz09SES17R6hxdHHz3wf-dICa1s9HAOGoHfoqKcCwIpzKDP9-BWz-FfJDMZM-KU8FIpuoDZYKPMUCv9sHudHhVBKs5E7VVh0zUnInCNNcs-3E0n9oddP9FxxAy8PsAQL7Fk4WgorHgDHQ2gEmq8_bjDW8u7p_R</recordid><startdate>20060208</startdate><enddate>20060208</enddate><creator>Cheng, Chen-Li</creator><creator>Chen, Kuo-Jung</creator><creator>Shih, Po-Hung</creator><creator>Lu, Lieng-Yi</creator><creator>Hung, Chia-Fang</creator><creator>Lin, Wen-Ching</creator><creator>Yesong Gu, Jason</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20060208</creationdate><title>Chronic renal failure rats are highly sensitive to aristolochic acids, which are nephrotoxic and carcinogenic agents</title><author>Cheng, Chen-Li ; Chen, Kuo-Jung ; Shih, Po-Hung ; Lu, Lieng-Yi ; Hung, Chia-Fang ; Lin, Wen-Ching ; Yesong Gu, Jason</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-48da28b98539f796e9e7c86b067542c9f580bc1dbaf18a2daf505f7c641797323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Aristolochic acid</topic><topic>Aristolochic Acids - toxicity</topic><topic>Chronic renal failure</topic><topic>Creatinine - blood</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Adducts - analysis</topic><topic>DNA repair</topic><topic>Genes</topic><topic>Genes, ras</topic><topic>Kidney - drug effects</topic><topic>Kidney Failure, Chronic - genetics</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Mutation</topic><topic>Neoplasms - chemically induced</topic><topic>Point Mutation</topic><topic>ras proto-oncogene</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RFLP</topic><topic>Rodents</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Chen-Li</creatorcontrib><creatorcontrib>Chen, Kuo-Jung</creatorcontrib><creatorcontrib>Shih, Po-Hung</creatorcontrib><creatorcontrib>Lu, Lieng-Yi</creatorcontrib><creatorcontrib>Hung, Chia-Fang</creatorcontrib><creatorcontrib>Lin, Wen-Ching</creatorcontrib><creatorcontrib>Yesong Gu, Jason</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Chen-Li</au><au>Chen, Kuo-Jung</au><au>Shih, Po-Hung</au><au>Lu, Lieng-Yi</au><au>Hung, Chia-Fang</au><au>Lin, Wen-Ching</au><au>Yesong Gu, Jason</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic renal failure rats are highly sensitive to aristolochic acids, which are nephrotoxic and carcinogenic agents</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2006-02-08</date><risdate>2006</risdate><volume>232</volume><issue>2</issue><spage>236</spage><epage>242</epage><pages>236-242</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Aristolochic acid (AA), a component of some Chinese herbal medicines, may cause Chinese Herbs Nephropathy (CHN) and multi-systemic tumors by the formation of AA–DNA adducts. In this study, we established an animal model to further characterize the mechanisms of AA-induced diseases. Our results indicated that AA significantly inhibited rat growth in terms of weight gain. By measuring the serum creatinine levels, AA resulted in considerable damage to the rat renal system, not only for those in which chronic renal failure (CRF) was induced but also for normal healthy rats. Mutation-specific polymerase chain reaction (PCR) and XbaI restriction fragment length polymorphism (RFLP) revealed the CAA→CTA transversion mutation at codon 61 of the H-
ras proto-oncogene from the stomach tissues of CRF rats fed with AA, but not from other tissues of rats in the same experimental group. In addition, no such mutations were found in the tissues of CRF rats without AA treatment or healthy rats fed with AA. Our results strongly demonstrated that AA was in fact nephrotoxic and carcinogenic, especially to those CRF rats.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>16458120</pmid><doi>10.1016/j.canlet.2005.02.021</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cancer letters, 2006-02, Vol.232 (2), p.236-242 |
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| subjects | Animals Aristolochic acid Aristolochic Acids - toxicity Chronic renal failure Creatinine - blood Deoxyribonucleic acid DNA DNA Adducts - analysis DNA repair Genes Genes, ras Kidney - drug effects Kidney Failure, Chronic - genetics Kidney Failure, Chronic - physiopathology Mutation Neoplasms - chemically induced Point Mutation ras proto-oncogene Rats Rats, Wistar RFLP Rodents Tumors |
| title | Chronic renal failure rats are highly sensitive to aristolochic acids, which are nephrotoxic and carcinogenic agents |
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