Interleukin-27 induces the endothelial differentiation in Sca-1+ cardiac resident stem cells

•IL-27Rα was expressed in cardiac Sca-1+ cells.•The transcript expression of IL-27 was elevated in hearts in cardiac injury models.•STAT3/Pim-1 axis was activated by IL-27 in cardiac Sca-1+ cells.•IL-27 induces the endothelial differentiation in Sca-1+ cells through STAT3/Pim-1. Cytokines play impor...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2015-10, Vol.75 (2), p.365-372
Hauptverfasser:	Tanaka, Tomohiro, Obana, Masanori, Mohri, Tomomi, Ebara, Masaki, Otani, Yuta, Maeda, Makiko, Fujio, Yasushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cadherins - biosynthesis Cardiac stem cells Cell Differentiation - physiology Cell Transdifferentiation - physiology Cells, Cultured Endothelial Cells - cytology Endothelial differentiation Heart Injuries - pathology Interleukin-12 - immunology Interleukin-27 Interleukins - immunology Interleukins - pharmacology Mice Mice, Inbred C57BL Myocardium - cytology Phosphorylation - drug effects Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis Proto-Oncogene Proteins c-pim-1 - biosynthesis Proto-Oncogene Proteins c-pim-1 - metabolism Receptors, Cytokine - biosynthesis Receptors, Interleukin - biosynthesis Receptors, Interleukin-12 - biosynthesis Signal transduction STAT3 Transcription Factor - metabolism Stem Cells - cytology
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