Impact of O6-methylguanine-DNA methyltransferase expression on the drug resistance of clear cell renal cell carcinoma

The deoxyribonucleic acid-repair protein O(6)-methylguanine-deoxyribonucleic acid methyltransferase is a major determinant of resistance of cells to various alkylating drugs. Its expression profile is different in different cancer types. Here, we studied the expression and function of O(6)-methylgua...

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Veröffentlicht in:	Japanese journal of clinical oncology 2015-09, Vol.45 (9), p.860-866
Hauptverfasser:	Ge, Nan, Guo, Liqiang, Zhang, Jie, Lin, Zhaomin, Li, Yan, Liu, Yuqiang, Kong, Feng, Fang, Xiaolei, Zhao, Shengtian
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents, Alkylating - pharmacology Antineoplastic Agents, Alkylating - therapeutic use Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell Line, Tumor Cell Survival - drug effects Drug Resistance, Neoplasm Female Humans Immunohistochemistry Kidney Neoplasms - drug therapy Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Male Middle Aged O-Methylguanine-DNA Methyltransferase - antagonists & inhibitors O-Methylguanine-DNA Methyltransferase - genetics O-Methylguanine-DNA Methyltransferase - metabolism Real-Time Polymerase Chain Reaction RNA Interference RNA, Messenger - metabolism RNA, Small Interfering - metabolism Up-Regulation - drug effects
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