Pneumococcal vaccination reduced the risk of acute otitis media: Cohort study
Background Seven‐valent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2009, and after that invasive pneumococcal disease has gradually decreased. There are few data, however, on the effectiveness of PCV7 against acute otitis media (AOM) in Japan. Methods From 10 daycare centers in...
Gespeichert in:
| Veröffentlicht in: | Pediatrics international 2015-08, Vol.57 (4), p.582-585 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 585 |
|---|---|
| container_issue | 4 |
| container_start_page | 582 |
| container_title | Pediatrics international |
| container_volume | 57 |
| creator | Hasegawa, Junko Mori, Mitsuru Showa, Satoko Matsushima, Aiko Ohnishi, Hirofumi Tsugawa, Takeshi Yoto, Yuko Tsutsumi, Hiroyuki |
| description | Background
Seven‐valent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2009, and after that invasive pneumococcal disease has gradually decreased. There are few data, however, on the effectiveness of PCV7 against acute otitis media (AOM) in Japan.
Methods
From 10 daycare centers in Sapporo, Japan, 614 parents participated in the survey. Each parent reported whether their child subject had received one or more doses of PCV7, and, if so, the exact dates of receiving PCV7 were verified by reviewing their maternal and child health handbooks marked by a pediatrician. AOM was diagnosed by otorhinolaryngologist or pediatrician. Cox's proportional hazard model was used for calculating the hazard ratio (HR) of AOM incidence reduced by PCV7 inoculation.
Results
Inoculation of PCV7 significantly reduced the risk of AOM (crude HR, 0.63; 95%CI: 0.50–0.79). Adjusting for potentially confounding variables reduced the risk further (adjusted HR, 0.32; 95%CI: 0.23–0.44). On stratification by subject age on 30 April 2012, PCV7 was significantly associated with a reduced risk of AOM in both infants |
| doi_str_mv | 10.1111/ped.12587 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1708162345</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3790703761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4817-aac360a3b43e7a832cfba3521598d8855c329b2837bc100052ce149fbfc0d0f83</originalsourceid><addsrcrecordid>eNp1kMtKAzEUhoMo3he-gATc6GJsLpNJ6k5qvUDVCoriJmQyGYxOJzXJqH17o60uBM_mnMX3_xw-AHYwOsRpelNTHWLCBF8C6zjPSUYQelhONyUiE6jga2AjhGeEkOAiXwVrhBWYiZyug8txa7qJ005r1cA3pbVtVbSuhd5UnTYVjE8GehteoKuh0l000EUbbYATU1l1BAfuyfkIQ-yq2RZYqVUTzPZib4K70-Ht4DwbXZ9dDI5Hmc4F5plSmhZI0TKnhitBia5LRRnBrC8qIRjTlPRLIigvNU5fM6INzvt1WWtUoVrQTbA_751699qZEOXEBm2aRrXGdUFijgQuCM1ZQvf-oM-u82367oviAqM-Qok6mFPauxC8qeXU24nyM4mR_HIsk2P57Tixu4vGrkwOfskfqQnozYF325jZ_01yPDz5qczmCRui-fhNKP8iC045k_dXZxIVj-PxzehKjugnEtCTpg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1707810900</pqid></control><display><type>article</type><title>Pneumococcal vaccination reduced the risk of acute otitis media: Cohort study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hasegawa, Junko ; Mori, Mitsuru ; Showa, Satoko ; Matsushima, Aiko ; Ohnishi, Hirofumi ; Tsugawa, Takeshi ; Yoto, Yuko ; Tsutsumi, Hiroyuki</creator><creatorcontrib>Hasegawa, Junko ; Mori, Mitsuru ; Showa, Satoko ; Matsushima, Aiko ; Ohnishi, Hirofumi ; Tsugawa, Takeshi ; Yoto, Yuko ; Tsutsumi, Hiroyuki</creatorcontrib><description>Background
Seven‐valent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2009, and after that invasive pneumococcal disease has gradually decreased. There are few data, however, on the effectiveness of PCV7 against acute otitis media (AOM) in Japan.
Methods
From 10 daycare centers in Sapporo, Japan, 614 parents participated in the survey. Each parent reported whether their child subject had received one or more doses of PCV7, and, if so, the exact dates of receiving PCV7 were verified by reviewing their maternal and child health handbooks marked by a pediatrician. AOM was diagnosed by otorhinolaryngologist or pediatrician. Cox's proportional hazard model was used for calculating the hazard ratio (HR) of AOM incidence reduced by PCV7 inoculation.
Results
Inoculation of PCV7 significantly reduced the risk of AOM (crude HR, 0.63; 95%CI: 0.50–0.79). Adjusting for potentially confounding variables reduced the risk further (adjusted HR, 0.32; 95%CI: 0.23–0.44). On stratification by subject age on 30 April 2012, PCV7 was significantly associated with a reduced risk of AOM in both infants <3 years old, and in children ≥3 years.
Conclusion
PCV7 is effectiveness in reducing the risk of AOM both in infants <3 years old, and in young children ≥3 years in Japan.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.12587</identifier><identifier>PMID: 25615843</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Acute Disease ; acute otitis media ; Child ; Child, Preschool ; children ; cohort study ; Ear diseases ; effectiveness ; Female ; Follow-Up Studies ; Heptavalent Pneumococcal Conjugate Vaccine - pharmacology ; Humans ; Incidence ; Infant ; Japan - epidemiology ; Male ; Maternal & child health ; Otitis Media - epidemiology ; Otitis Media - microbiology ; Otitis Media - prevention & control ; Pediatrics ; pneumococcal conjugate vaccine ; Pneumococcal Infections - epidemiology ; Pneumococcal Infections - prevention & control ; Pneumonia ; Prospective Studies ; Retrospective Studies ; Streptococcus pneumoniae - immunology ; Vaccination - methods ; Vaccines ; Vaccines, Conjugate</subject><ispartof>Pediatrics international, 2015-08, Vol.57 (4), p.582-585</ispartof><rights>2015 Japan Pediatric Society</rights><rights>2015 Japan Pediatric Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4817-aac360a3b43e7a832cfba3521598d8855c329b2837bc100052ce149fbfc0d0f83</citedby><cites>FETCH-LOGICAL-c4817-aac360a3b43e7a832cfba3521598d8855c329b2837bc100052ce149fbfc0d0f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fped.12587$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fped.12587$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25615843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasegawa, Junko</creatorcontrib><creatorcontrib>Mori, Mitsuru</creatorcontrib><creatorcontrib>Showa, Satoko</creatorcontrib><creatorcontrib>Matsushima, Aiko</creatorcontrib><creatorcontrib>Ohnishi, Hirofumi</creatorcontrib><creatorcontrib>Tsugawa, Takeshi</creatorcontrib><creatorcontrib>Yoto, Yuko</creatorcontrib><creatorcontrib>Tsutsumi, Hiroyuki</creatorcontrib><title>Pneumococcal vaccination reduced the risk of acute otitis media: Cohort study</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background
Seven‐valent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2009, and after that invasive pneumococcal disease has gradually decreased. There are few data, however, on the effectiveness of PCV7 against acute otitis media (AOM) in Japan.
Methods
From 10 daycare centers in Sapporo, Japan, 614 parents participated in the survey. Each parent reported whether their child subject had received one or more doses of PCV7, and, if so, the exact dates of receiving PCV7 were verified by reviewing their maternal and child health handbooks marked by a pediatrician. AOM was diagnosed by otorhinolaryngologist or pediatrician. Cox's proportional hazard model was used for calculating the hazard ratio (HR) of AOM incidence reduced by PCV7 inoculation.
Results
Inoculation of PCV7 significantly reduced the risk of AOM (crude HR, 0.63; 95%CI: 0.50–0.79). Adjusting for potentially confounding variables reduced the risk further (adjusted HR, 0.32; 95%CI: 0.23–0.44). On stratification by subject age on 30 April 2012, PCV7 was significantly associated with a reduced risk of AOM in both infants <3 years old, and in children ≥3 years.
Conclusion
PCV7 is effectiveness in reducing the risk of AOM both in infants <3 years old, and in young children ≥3 years in Japan.</description><subject>Acute Disease</subject><subject>acute otitis media</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>cohort study</subject><subject>Ear diseases</subject><subject>effectiveness</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heptavalent Pneumococcal Conjugate Vaccine - pharmacology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Maternal & child health</subject><subject>Otitis Media - epidemiology</subject><subject>Otitis Media - microbiology</subject><subject>Otitis Media - prevention & control</subject><subject>Pediatrics</subject><subject>pneumococcal conjugate vaccine</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumonia</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Vaccination - methods</subject><subject>Vaccines</subject><subject>Vaccines, Conjugate</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUhoMo3he-gATc6GJsLpNJ6k5qvUDVCoriJmQyGYxOJzXJqH17o60uBM_mnMX3_xw-AHYwOsRpelNTHWLCBF8C6zjPSUYQelhONyUiE6jga2AjhGeEkOAiXwVrhBWYiZyug8txa7qJ005r1cA3pbVtVbSuhd5UnTYVjE8GehteoKuh0l000EUbbYATU1l1BAfuyfkIQ-yq2RZYqVUTzPZib4K70-Ht4DwbXZ9dDI5Hmc4F5plSmhZI0TKnhitBia5LRRnBrC8qIRjTlPRLIigvNU5fM6INzvt1WWtUoVrQTbA_751699qZEOXEBm2aRrXGdUFijgQuCM1ZQvf-oM-u82367oviAqM-Qok6mFPauxC8qeXU24nyM4mR_HIsk2P57Tixu4vGrkwOfskfqQnozYF325jZ_01yPDz5qczmCRui-fhNKP8iC045k_dXZxIVj-PxzehKjugnEtCTpg</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Hasegawa, Junko</creator><creator>Mori, Mitsuru</creator><creator>Showa, Satoko</creator><creator>Matsushima, Aiko</creator><creator>Ohnishi, Hirofumi</creator><creator>Tsugawa, Takeshi</creator><creator>Yoto, Yuko</creator><creator>Tsutsumi, Hiroyuki</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201508</creationdate><title>Pneumococcal vaccination reduced the risk of acute otitis media: Cohort study</title><author>Hasegawa, Junko ; Mori, Mitsuru ; Showa, Satoko ; Matsushima, Aiko ; Ohnishi, Hirofumi ; Tsugawa, Takeshi ; Yoto, Yuko ; Tsutsumi, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4817-aac360a3b43e7a832cfba3521598d8855c329b2837bc100052ce149fbfc0d0f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute Disease</topic><topic>acute otitis media</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>cohort study</topic><topic>Ear diseases</topic><topic>effectiveness</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heptavalent Pneumococcal Conjugate Vaccine - pharmacology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Maternal & child health</topic><topic>Otitis Media - epidemiology</topic><topic>Otitis Media - microbiology</topic><topic>Otitis Media - prevention & control</topic><topic>Pediatrics</topic><topic>pneumococcal conjugate vaccine</topic><topic>Pneumococcal Infections - epidemiology</topic><topic>Pneumococcal Infections - prevention & control</topic><topic>Pneumonia</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Vaccination - methods</topic><topic>Vaccines</topic><topic>Vaccines, Conjugate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasegawa, Junko</creatorcontrib><creatorcontrib>Mori, Mitsuru</creatorcontrib><creatorcontrib>Showa, Satoko</creatorcontrib><creatorcontrib>Matsushima, Aiko</creatorcontrib><creatorcontrib>Ohnishi, Hirofumi</creatorcontrib><creatorcontrib>Tsugawa, Takeshi</creatorcontrib><creatorcontrib>Yoto, Yuko</creatorcontrib><creatorcontrib>Tsutsumi, Hiroyuki</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasegawa, Junko</au><au>Mori, Mitsuru</au><au>Showa, Satoko</au><au>Matsushima, Aiko</au><au>Ohnishi, Hirofumi</au><au>Tsugawa, Takeshi</au><au>Yoto, Yuko</au><au>Tsutsumi, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pneumococcal vaccination reduced the risk of acute otitis media: Cohort study</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2015-08</date><risdate>2015</risdate><volume>57</volume><issue>4</issue><spage>582</spage><epage>585</epage><pages>582-585</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background
Seven‐valent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2009, and after that invasive pneumococcal disease has gradually decreased. There are few data, however, on the effectiveness of PCV7 against acute otitis media (AOM) in Japan.
Methods
From 10 daycare centers in Sapporo, Japan, 614 parents participated in the survey. Each parent reported whether their child subject had received one or more doses of PCV7, and, if so, the exact dates of receiving PCV7 were verified by reviewing their maternal and child health handbooks marked by a pediatrician. AOM was diagnosed by otorhinolaryngologist or pediatrician. Cox's proportional hazard model was used for calculating the hazard ratio (HR) of AOM incidence reduced by PCV7 inoculation.
Results
Inoculation of PCV7 significantly reduced the risk of AOM (crude HR, 0.63; 95%CI: 0.50–0.79). Adjusting for potentially confounding variables reduced the risk further (adjusted HR, 0.32; 95%CI: 0.23–0.44). On stratification by subject age on 30 April 2012, PCV7 was significantly associated with a reduced risk of AOM in both infants <3 years old, and in children ≥3 years.
Conclusion
PCV7 is effectiveness in reducing the risk of AOM both in infants <3 years old, and in young children ≥3 years in Japan.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25615843</pmid><doi>10.1111/ped.12587</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1328-8067 |
| ispartof | Pediatrics international, 2015-08, Vol.57 (4), p.582-585 |
| issn | 1328-8067 1442-200X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1708162345 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acute Disease acute otitis media Child Child, Preschool children cohort study Ear diseases effectiveness Female Follow-Up Studies Heptavalent Pneumococcal Conjugate Vaccine - pharmacology Humans Incidence Infant Japan - epidemiology Male Maternal & child health Otitis Media - epidemiology Otitis Media - microbiology Otitis Media - prevention & control Pediatrics pneumococcal conjugate vaccine Pneumococcal Infections - epidemiology Pneumococcal Infections - prevention & control Pneumonia Prospective Studies Retrospective Studies Streptococcus pneumoniae - immunology Vaccination - methods Vaccines Vaccines, Conjugate |
| title | Pneumococcal vaccination reduced the risk of acute otitis media: Cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T19%3A14%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pneumococcal%20vaccination%20reduced%20the%20risk%20of%20acute%20otitis%20media:%20Cohort%20study&rft.jtitle=Pediatrics%20international&rft.au=Hasegawa,%20Junko&rft.date=2015-08&rft.volume=57&rft.issue=4&rft.spage=582&rft.epage=585&rft.pages=582-585&rft.issn=1328-8067&rft.eissn=1442-200X&rft_id=info:doi/10.1111/ped.12587&rft_dat=%3Cproquest_cross%3E3790703761%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1707810900&rft_id=info:pmid/25615843&rfr_iscdi=true |