Efficient dermal delivery of retinyl palmitate: Progressive polarimetry and Raman spectroscopy to evaluate the structure and efficacy
[Display omitted] Over the past decades, there has been a growing interest in dermal drug delivery. Although various novel delivery devices and methods have been developed, dermal delivery is still challenging because of problems such as poor drug permeation, instability of vesicles and drug leakage...
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| Veröffentlicht in: | European journal of pharmaceutical sciences 2015-10, Vol.78, p.111-120 |
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| container_title | European journal of pharmaceutical sciences |
| container_volume | 78 |
| creator | Lee, Jun Bae Lee, Dong Ryeol Choi, Nak Cho Jang, Jihui Park, Chun Ho Yoon, Moung Seok Lee, Miyoung Won, Kyoungae Hwang, Jae Sung Kim, B. Moon |
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Over the past decades, there has been a growing interest in dermal drug delivery. Although various novel delivery devices and methods have been developed, dermal delivery is still challenging because of problems such as poor drug permeation, instability of vesicles and drug leakage from vesicles induced by fusion of vesicles. To solve the vesicle instability problems in current dermal delivery systems, we developed materials comprised of liquid crystals as a new delivery vehicle of retinyl palmitate and report the characterization of the liquid crystals using a Mueller matrix polarimetry. The stability of the liquid-crystal materials was evaluated using the polarimeter as a novel evaluation tool along with other conventional methods. The dermal delivery of retinyl palmitate was investigated through the use of confocal Raman spectroscopy. The results indicate that the permeation of retinyl palmitate was enhanced by up to 106% compared to that using an ordinary emulsion with retinyl palmitate. |
| doi_str_mv | 10.1016/j.ejps.2015.07.009 |
| format | Article |
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Over the past decades, there has been a growing interest in dermal drug delivery. Although various novel delivery devices and methods have been developed, dermal delivery is still challenging because of problems such as poor drug permeation, instability of vesicles and drug leakage from vesicles induced by fusion of vesicles. To solve the vesicle instability problems in current dermal delivery systems, we developed materials comprised of liquid crystals as a new delivery vehicle of retinyl palmitate and report the characterization of the liquid crystals using a Mueller matrix polarimetry. The stability of the liquid-crystal materials was evaluated using the polarimeter as a novel evaluation tool along with other conventional methods. The dermal delivery of retinyl palmitate was investigated through the use of confocal Raman spectroscopy. The results indicate that the permeation of retinyl palmitate was enhanced by up to 106% compared to that using an ordinary emulsion with retinyl palmitate.</description><identifier>ISSN: 0928-0987</identifier><identifier>EISSN: 1879-0720</identifier><identifier>DOI: 10.1016/j.ejps.2015.07.009</identifier><identifier>PMID: 26165622</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Cutaneous ; Adult ; Confocal Raman spectroscopy ; Dermal delivery ; Emulsions ; Female ; Humans ; Lipids - chemistry ; Liquid Crystals - chemistry ; Liquid-crystal emulsion ; Molecular Structure ; Mueller matrix polarimeter ; Retinyl palmitate ; Skin Absorption ; Spectrum Analysis, Raman ; Vitamin A - administration & dosage ; Vitamin A - analogs & derivatives ; Vitamin A - chemistry</subject><ispartof>European journal of pharmaceutical sciences, 2015-10, Vol.78, p.111-120</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-10631a0531e3e7f6930c786986d4248a187dff1ee5c6315f6a7b91cdb8d725b53</citedby><cites>FETCH-LOGICAL-c356t-10631a0531e3e7f6930c786986d4248a187dff1ee5c6315f6a7b91cdb8d725b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0928098715003309$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26165622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jun Bae</creatorcontrib><creatorcontrib>Lee, Dong Ryeol</creatorcontrib><creatorcontrib>Choi, Nak Cho</creatorcontrib><creatorcontrib>Jang, Jihui</creatorcontrib><creatorcontrib>Park, Chun Ho</creatorcontrib><creatorcontrib>Yoon, Moung Seok</creatorcontrib><creatorcontrib>Lee, Miyoung</creatorcontrib><creatorcontrib>Won, Kyoungae</creatorcontrib><creatorcontrib>Hwang, Jae Sung</creatorcontrib><creatorcontrib>Kim, B. Moon</creatorcontrib><title>Efficient dermal delivery of retinyl palmitate: Progressive polarimetry and Raman spectroscopy to evaluate the structure and efficacy</title><title>European journal of pharmaceutical sciences</title><addtitle>Eur J Pharm Sci</addtitle><description>[Display omitted]
Over the past decades, there has been a growing interest in dermal drug delivery. Although various novel delivery devices and methods have been developed, dermal delivery is still challenging because of problems such as poor drug permeation, instability of vesicles and drug leakage from vesicles induced by fusion of vesicles. To solve the vesicle instability problems in current dermal delivery systems, we developed materials comprised of liquid crystals as a new delivery vehicle of retinyl palmitate and report the characterization of the liquid crystals using a Mueller matrix polarimetry. The stability of the liquid-crystal materials was evaluated using the polarimeter as a novel evaluation tool along with other conventional methods. The dermal delivery of retinyl palmitate was investigated through the use of confocal Raman spectroscopy. The results indicate that the permeation of retinyl palmitate was enhanced by up to 106% compared to that using an ordinary emulsion with retinyl palmitate.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Confocal Raman spectroscopy</subject><subject>Dermal delivery</subject><subject>Emulsions</subject><subject>Female</subject><subject>Humans</subject><subject>Lipids - chemistry</subject><subject>Liquid Crystals - chemistry</subject><subject>Liquid-crystal emulsion</subject><subject>Molecular Structure</subject><subject>Mueller matrix polarimeter</subject><subject>Retinyl palmitate</subject><subject>Skin Absorption</subject><subject>Spectrum Analysis, Raman</subject><subject>Vitamin A - administration & dosage</subject><subject>Vitamin A - analogs & derivatives</subject><subject>Vitamin A - chemistry</subject><issn>0928-0987</issn><issn>1879-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAUhS0EotPCC7BAXrJJuHYa20FsUFUoUqWiqqwtj3MNHjk_2M5IeQDeG4cpLLu6m--cq_MR8oZBzYCJ94caD3OqObC2BlkDdM_IjinZVSA5PCc76LiqoFPyjJyndAAAoSS8JGdcMNEKznfk97Vz3nocM-0xDiaUE_wR40onRyNmP66BziYMPpuMH-i3OP2ImFJh6DwFE_2AudBm7Om9GcxI04w2xynZaV5pnigeTVhKluafSFOOi81LxL8B3J4bu74iL5wJCV8_3gvy_fP1w9VNdXv35evVp9vKNq3IFQPRMANtw7BB6UTXgJVKdEr0l_xSmbK9d44htraArRNG7jtm-73qJW_3bXNB3p165zj9WjBlPfhkMQQz4rQkzSQoJljHmoLyE2rLlBTR6blMNXHVDPSmXx_0pl9v-jVIXfSX0NvH_mU_YP8_8s93AT6eACwrjx6jTpt8i72PxZruJ_9U_x8StZlI</recordid><startdate>20151012</startdate><enddate>20151012</enddate><creator>Lee, Jun Bae</creator><creator>Lee, Dong Ryeol</creator><creator>Choi, Nak Cho</creator><creator>Jang, Jihui</creator><creator>Park, Chun Ho</creator><creator>Yoon, Moung Seok</creator><creator>Lee, Miyoung</creator><creator>Won, Kyoungae</creator><creator>Hwang, Jae Sung</creator><creator>Kim, B. Moon</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151012</creationdate><title>Efficient dermal delivery of retinyl palmitate: Progressive polarimetry and Raman spectroscopy to evaluate the structure and efficacy</title><author>Lee, Jun Bae ; Lee, Dong Ryeol ; Choi, Nak Cho ; Jang, Jihui ; Park, Chun Ho ; Yoon, Moung Seok ; Lee, Miyoung ; Won, Kyoungae ; Hwang, Jae Sung ; Kim, B. Moon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-10631a0531e3e7f6930c786986d4248a187dff1ee5c6315f6a7b91cdb8d725b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Confocal Raman spectroscopy</topic><topic>Dermal delivery</topic><topic>Emulsions</topic><topic>Female</topic><topic>Humans</topic><topic>Lipids - chemistry</topic><topic>Liquid Crystals - chemistry</topic><topic>Liquid-crystal emulsion</topic><topic>Molecular Structure</topic><topic>Mueller matrix polarimeter</topic><topic>Retinyl palmitate</topic><topic>Skin Absorption</topic><topic>Spectrum Analysis, Raman</topic><topic>Vitamin A - administration & dosage</topic><topic>Vitamin A - analogs & derivatives</topic><topic>Vitamin A - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jun Bae</creatorcontrib><creatorcontrib>Lee, Dong Ryeol</creatorcontrib><creatorcontrib>Choi, Nak Cho</creatorcontrib><creatorcontrib>Jang, Jihui</creatorcontrib><creatorcontrib>Park, Chun Ho</creatorcontrib><creatorcontrib>Yoon, Moung Seok</creatorcontrib><creatorcontrib>Lee, Miyoung</creatorcontrib><creatorcontrib>Won, Kyoungae</creatorcontrib><creatorcontrib>Hwang, Jae Sung</creatorcontrib><creatorcontrib>Kim, B. 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Moon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficient dermal delivery of retinyl palmitate: Progressive polarimetry and Raman spectroscopy to evaluate the structure and efficacy</atitle><jtitle>European journal of pharmaceutical sciences</jtitle><addtitle>Eur J Pharm Sci</addtitle><date>2015-10-12</date><risdate>2015</risdate><volume>78</volume><spage>111</spage><epage>120</epage><pages>111-120</pages><issn>0928-0987</issn><eissn>1879-0720</eissn><abstract>[Display omitted]
Over the past decades, there has been a growing interest in dermal drug delivery. Although various novel delivery devices and methods have been developed, dermal delivery is still challenging because of problems such as poor drug permeation, instability of vesicles and drug leakage from vesicles induced by fusion of vesicles. To solve the vesicle instability problems in current dermal delivery systems, we developed materials comprised of liquid crystals as a new delivery vehicle of retinyl palmitate and report the characterization of the liquid crystals using a Mueller matrix polarimetry. The stability of the liquid-crystal materials was evaluated using the polarimeter as a novel evaluation tool along with other conventional methods. The dermal delivery of retinyl palmitate was investigated through the use of confocal Raman spectroscopy. The results indicate that the permeation of retinyl palmitate was enhanced by up to 106% compared to that using an ordinary emulsion with retinyl palmitate.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26165622</pmid><doi>10.1016/j.ejps.2015.07.009</doi><tpages>10</tpages></addata></record> |
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| ispartof | European journal of pharmaceutical sciences, 2015-10, Vol.78, p.111-120 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Cutaneous Adult Confocal Raman spectroscopy Dermal delivery Emulsions Female Humans Lipids - chemistry Liquid Crystals - chemistry Liquid-crystal emulsion Molecular Structure Mueller matrix polarimeter Retinyl palmitate Skin Absorption Spectrum Analysis, Raman Vitamin A - administration & dosage Vitamin A - analogs & derivatives Vitamin A - chemistry |
| title | Efficient dermal delivery of retinyl palmitate: Progressive polarimetry and Raman spectroscopy to evaluate the structure and efficacy |
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