Vitamin B12 deficiency in the institutionalized elderly: A regional study
The prevalence of vitamin B12 deficiency increases with age and is suggested to be even higher in the elderly living in institutions. This retrospective study evaluated the vitamin B12 and folate status of 1996 institutionalized elderly residents aged over 65years. Among them, 34.9% had vitamin B12...
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| Veröffentlicht in: | Experimental gerontology 2015-09, Vol.69, p.221-225 |
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| container_title | Experimental gerontology |
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| creator | Wong, C.W. Ip, C.Y. Leung, C.P. Leung, C.S. Cheng, J.N. Siu, C.Y. |
| description | The prevalence of vitamin B12 deficiency increases with age and is suggested to be even higher in the elderly living in institutions. This retrospective study evaluated the vitamin B12 and folate status of 1996 institutionalized elderly residents aged over 65years. Among them, 34.9% had vitamin B12 deficiency (serum vitamin B12 |
| doi_str_mv | 10.1016/j.exger.2015.06.016 |
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•Vitamin B12 deficiency is common in the institutionalized elderly with a prevalence of 34.9%.•The majority (68%) of vitamin B12 deficiency is of a relatively less severe degree.•Macrocytosis was found in 24.2% of vitamin B12 deficient residents.•A significant increase in macrocytosis was associated with a decrease in serum vitamin B12 below 100pmol/L.</description><identifier>ISSN: 0531-5565</identifier><identifier>EISSN: 1873-6815</identifier><identifier>DOI: 10.1016/j.exger.2015.06.016</identifier><identifier>PMID: 26122132</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Anaemia ; China - epidemiology ; Elderly ; Erythrocyte Indices ; Female ; Folate ; Folic Acid - blood ; Folic Acid Deficiency - blood ; Folic Acid Deficiency - diagnosis ; Folic Acid Deficiency - epidemiology ; Folic Acid Deficiency - etiology ; Humans ; Institution ; Institutionalization - statistics & numerical data ; Macrocytosis ; Male ; Prevalence ; Residential Facilities - statistics & numerical data ; Retrospective Studies ; Vitamin B 12 - blood ; Vitamin B 12 Deficiency - blood ; Vitamin B 12 Deficiency - diagnosis ; Vitamin B 12 Deficiency - epidemiology ; Vitamin B 12 Deficiency - etiology ; Vitamin B12 ; Vitamin B12 deficiency</subject><ispartof>Experimental gerontology, 2015-09, Vol.69, p.221-225</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c274t-c86294ced63485be9035ec4bc0e4becbef7a02180d614995dcd9ac26fa61be23</citedby><cites>FETCH-LOGICAL-c274t-c86294ced63485be9035ec4bc0e4becbef7a02180d614995dcd9ac26fa61be23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0531556515300024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26122132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, C.W.</creatorcontrib><creatorcontrib>Ip, C.Y.</creatorcontrib><creatorcontrib>Leung, C.P.</creatorcontrib><creatorcontrib>Leung, C.S.</creatorcontrib><creatorcontrib>Cheng, J.N.</creatorcontrib><creatorcontrib>Siu, C.Y.</creatorcontrib><title>Vitamin B12 deficiency in the institutionalized elderly: A regional study</title><title>Experimental gerontology</title><addtitle>Exp Gerontol</addtitle><description>The prevalence of vitamin B12 deficiency increases with age and is suggested to be even higher in the elderly living in institutions. This retrospective study evaluated the vitamin B12 and folate status of 1996 institutionalized elderly residents aged over 65years. Among them, 34.9% had vitamin B12 deficiency (serum vitamin B12 <150pmol/L), 11.8% had folate deficiency (serum folate <6.8nmol/L), and 4.9% had both. The majority of vitamin B12 deficient residents (68%) had serum vitamin B12 between 100pmol/L and 149pmol/L. Macrocytosis was found in 24.2% of vitamin B12 deficient residents. A significant increase in macrocytosis was associated with a decrease in serum vitamin B12 below 100pmol/L. Macrocytosis was most common in those with vitamin B12 ≦69pmol/L (50.9%). Overall, vitamin B12 deficiency is common in the institutionalized elderly, however macrocytosis cannot predict deficiency. More liberal testing for vitamin B12 status in the institutionalized elderly may be warranted.
•Vitamin B12 deficiency is common in the institutionalized elderly with a prevalence of 34.9%.•The majority (68%) of vitamin B12 deficiency is of a relatively less severe degree.•Macrocytosis was found in 24.2% of vitamin B12 deficient residents.•A significant increase in macrocytosis was associated with a decrease in serum vitamin B12 below 100pmol/L.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anaemia</subject><subject>China - epidemiology</subject><subject>Elderly</subject><subject>Erythrocyte Indices</subject><subject>Female</subject><subject>Folate</subject><subject>Folic Acid - blood</subject><subject>Folic Acid Deficiency - blood</subject><subject>Folic Acid Deficiency - diagnosis</subject><subject>Folic Acid Deficiency - epidemiology</subject><subject>Folic Acid Deficiency - etiology</subject><subject>Humans</subject><subject>Institution</subject><subject>Institutionalization - statistics & numerical data</subject><subject>Macrocytosis</subject><subject>Male</subject><subject>Prevalence</subject><subject>Residential Facilities - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B 12 Deficiency - blood</subject><subject>Vitamin B 12 Deficiency - diagnosis</subject><subject>Vitamin B 12 Deficiency - epidemiology</subject><subject>Vitamin B 12 Deficiency - etiology</subject><subject>Vitamin B12</subject><subject>Vitamin B12 deficiency</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMobk4_gSB99KU1N2nSVvBBh_9A8GX4GtrkVjO6dSapOD-92aY--nTgcM493B8hp0AzoCAv5hl-vqLLGAWRUZlFb4-MoSx4KksQ-2RMBYdUCClG5Mj7OaVUMg6HZMQkMAacjcnjiw31wi6TG2CJwdZqi0u9TqIT3jCKDzYMwfbLurNfaBLsDLpufZlcJw5ft37iw2DWx-SgrTuPJz86IbO729n0IX16vn-cXj-lmhV5SHUpWZVrNJLnpWiwolygzhtNMW9QN9gWNWVQUiMhryphtKlqzWRbS2iQ8Qk5351duf59QB_UwnqNXVcvsR-8goKWIKEAHqN8F9Wu995hq1bOLmq3VkDVBqGaqy1CtUGoqFTRi62zn4GhWaD56_wyi4GrXQDjlx821v0WGhrrUAdlevvvwDe1KINs</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Wong, C.W.</creator><creator>Ip, C.Y.</creator><creator>Leung, C.P.</creator><creator>Leung, C.S.</creator><creator>Cheng, J.N.</creator><creator>Siu, C.Y.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>Vitamin B12 deficiency in the institutionalized elderly: A regional study</title><author>Wong, C.W. ; Ip, C.Y. ; Leung, C.P. ; Leung, C.S. ; Cheng, J.N. ; Siu, C.Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c274t-c86294ced63485be9035ec4bc0e4becbef7a02180d614995dcd9ac26fa61be23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anaemia</topic><topic>China - epidemiology</topic><topic>Elderly</topic><topic>Erythrocyte Indices</topic><topic>Female</topic><topic>Folate</topic><topic>Folic Acid - blood</topic><topic>Folic Acid Deficiency - blood</topic><topic>Folic Acid Deficiency - diagnosis</topic><topic>Folic Acid Deficiency - epidemiology</topic><topic>Folic Acid Deficiency - etiology</topic><topic>Humans</topic><topic>Institution</topic><topic>Institutionalization - statistics & numerical data</topic><topic>Macrocytosis</topic><topic>Male</topic><topic>Prevalence</topic><topic>Residential Facilities - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamin B 12 Deficiency - blood</topic><topic>Vitamin B 12 Deficiency - diagnosis</topic><topic>Vitamin B 12 Deficiency - epidemiology</topic><topic>Vitamin B 12 Deficiency - etiology</topic><topic>Vitamin B12</topic><topic>Vitamin B12 deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, C.W.</creatorcontrib><creatorcontrib>Ip, C.Y.</creatorcontrib><creatorcontrib>Leung, C.P.</creatorcontrib><creatorcontrib>Leung, C.S.</creatorcontrib><creatorcontrib>Cheng, J.N.</creatorcontrib><creatorcontrib>Siu, C.Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, C.W.</au><au>Ip, C.Y.</au><au>Leung, C.P.</au><au>Leung, C.S.</au><au>Cheng, J.N.</au><au>Siu, C.Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin B12 deficiency in the institutionalized elderly: A regional study</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>2015-09</date><risdate>2015</risdate><volume>69</volume><spage>221</spage><epage>225</epage><pages>221-225</pages><issn>0531-5565</issn><eissn>1873-6815</eissn><abstract>The prevalence of vitamin B12 deficiency increases with age and is suggested to be even higher in the elderly living in institutions. This retrospective study evaluated the vitamin B12 and folate status of 1996 institutionalized elderly residents aged over 65years. Among them, 34.9% had vitamin B12 deficiency (serum vitamin B12 <150pmol/L), 11.8% had folate deficiency (serum folate <6.8nmol/L), and 4.9% had both. The majority of vitamin B12 deficient residents (68%) had serum vitamin B12 between 100pmol/L and 149pmol/L. Macrocytosis was found in 24.2% of vitamin B12 deficient residents. A significant increase in macrocytosis was associated with a decrease in serum vitamin B12 below 100pmol/L. Macrocytosis was most common in those with vitamin B12 ≦69pmol/L (50.9%). Overall, vitamin B12 deficiency is common in the institutionalized elderly, however macrocytosis cannot predict deficiency. More liberal testing for vitamin B12 status in the institutionalized elderly may be warranted.
•Vitamin B12 deficiency is common in the institutionalized elderly with a prevalence of 34.9%.•The majority (68%) of vitamin B12 deficiency is of a relatively less severe degree.•Macrocytosis was found in 24.2% of vitamin B12 deficient residents.•A significant increase in macrocytosis was associated with a decrease in serum vitamin B12 below 100pmol/L.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>26122132</pmid><doi>10.1016/j.exger.2015.06.016</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Anaemia China - epidemiology Elderly Erythrocyte Indices Female Folate Folic Acid - blood Folic Acid Deficiency - blood Folic Acid Deficiency - diagnosis Folic Acid Deficiency - epidemiology Folic Acid Deficiency - etiology Humans Institution Institutionalization - statistics & numerical data Macrocytosis Male Prevalence Residential Facilities - statistics & numerical data Retrospective Studies Vitamin B 12 - blood Vitamin B 12 Deficiency - blood Vitamin B 12 Deficiency - diagnosis Vitamin B 12 Deficiency - epidemiology Vitamin B 12 Deficiency - etiology Vitamin B12 Vitamin B12 deficiency |
| title | Vitamin B12 deficiency in the institutionalized elderly: A regional study |
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