Incidence and prognosis of systemic lupus erythematosus in a 35 year period in Fukushima, Japan
Background We examined the epidemiology, clinical manifestations, and prognosis of pediatric systemic lupus erythematosus (SLE) in Fukushima Prefecture, Japan over a 35 year period. Methods We collected the medical records of 37 patients diagnosed with SLE between 1977 and 2013. These children were...
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| Veröffentlicht in: | Pediatrics international 2015-08, Vol.57 (4), p.650-655 |
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| creator | Kawasaki, Yukihiko Ohara, Shinichiro Miyazaki, Kyohei Kanno, Shuto Ono, Atsushi Suyama, Kazuhide Sato, Masatoki Suzuki, Shigeo Maeda, Ryo Nagasawa, Katsutoshi Hosoya, Mitsuaki |
| description | Background
We examined the epidemiology, clinical manifestations, and prognosis of pediatric systemic lupus erythematosus (SLE) in Fukushima Prefecture, Japan over a 35 year period.
Methods
We collected the medical records of 37 patients diagnosed with SLE between 1977 and 2013. These children were divided into two groups. group 1 consisted of 19 patients who were diagnosed between 1977 and 1995, and group 2 consisted of 18 patients diagnosed between 1996 and 2013. The epidemiology, clinical features, and prognosis were retrospectively compared between the two groups.
Results
The mean number of patients per 100 000 children per year for group 1 and group 2 was 0.33 ± 0.25 and 0.35 ± 0.30, respectively. The duration from onset of symptoms to treatment in group 2 was shorter than that in group 1, but the clinical and laboratory findings at onset did not differ between the two groups. All patients were treated with prednisolone, and 17 patients in group 1 and 18 in group 2 were treated with methylprednisolone pulse therapy. The frequency of cyclophosphamide treatment decreased whereas the frequency of cyclosporine, tacrolimus and mizoribine pulse therapy increased in group 2. SLE disease activity index (SLEDAI) score at the latest follow up in group 2 was lower in group 1. The survival rate was 84% in group 1 and 100% in group 2.
Conclusion
The frequency and severity of SLE in group 1 were similar to those in group 2, and the prognosis of SLE in group 2 was better than that in group 1. |
| doi_str_mv | 10.1111/ped.12588 |
| format | Article |
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We examined the epidemiology, clinical manifestations, and prognosis of pediatric systemic lupus erythematosus (SLE) in Fukushima Prefecture, Japan over a 35 year period.
Methods
We collected the medical records of 37 patients diagnosed with SLE between 1977 and 2013. These children were divided into two groups. group 1 consisted of 19 patients who were diagnosed between 1977 and 1995, and group 2 consisted of 18 patients diagnosed between 1996 and 2013. The epidemiology, clinical features, and prognosis were retrospectively compared between the two groups.
Results
The mean number of patients per 100 000 children per year for group 1 and group 2 was 0.33 ± 0.25 and 0.35 ± 0.30, respectively. The duration from onset of symptoms to treatment in group 2 was shorter than that in group 1, but the clinical and laboratory findings at onset did not differ between the two groups. All patients were treated with prednisolone, and 17 patients in group 1 and 18 in group 2 were treated with methylprednisolone pulse therapy. The frequency of cyclophosphamide treatment decreased whereas the frequency of cyclosporine, tacrolimus and mizoribine pulse therapy increased in group 2. SLE disease activity index (SLEDAI) score at the latest follow up in group 2 was lower in group 1. The survival rate was 84% in group 1 and 100% in group 2.
Conclusion
The frequency and severity of SLE in group 1 were similar to those in group 2, and the prognosis of SLE in group 2 was better than that in group 1.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.12588</identifier><identifier>PMID: 25615939</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Age of Onset ; Biopsy ; Bredinin ; Child ; clinical manifestation ; epidemiology ; Female ; Follow-Up Studies ; Forecasting ; Humans ; Incidence ; Japan - epidemiology ; Lupus Erythematosus, Systemic - diagnosis ; Lupus Erythematosus, Systemic - epidemiology ; Male ; methylprednisolone ; Retrospective Studies ; Severity of Illness Index ; Survival Rate - trends ; systemic lupus erythematosus</subject><ispartof>Pediatrics international, 2015-08, Vol.57 (4), p.650-655</ispartof><rights>2015 Japan Pediatric Society</rights><rights>2015 Japan Pediatric Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fped.12588$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fped.12588$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25615939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawasaki, Yukihiko</creatorcontrib><creatorcontrib>Ohara, Shinichiro</creatorcontrib><creatorcontrib>Miyazaki, Kyohei</creatorcontrib><creatorcontrib>Kanno, Shuto</creatorcontrib><creatorcontrib>Ono, Atsushi</creatorcontrib><creatorcontrib>Suyama, Kazuhide</creatorcontrib><creatorcontrib>Sato, Masatoki</creatorcontrib><creatorcontrib>Suzuki, Shigeo</creatorcontrib><creatorcontrib>Maeda, Ryo</creatorcontrib><creatorcontrib>Nagasawa, Katsutoshi</creatorcontrib><creatorcontrib>Hosoya, Mitsuaki</creatorcontrib><title>Incidence and prognosis of systemic lupus erythematosus in a 35 year period in Fukushima, Japan</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background
We examined the epidemiology, clinical manifestations, and prognosis of pediatric systemic lupus erythematosus (SLE) in Fukushima Prefecture, Japan over a 35 year period.
Methods
We collected the medical records of 37 patients diagnosed with SLE between 1977 and 2013. These children were divided into two groups. group 1 consisted of 19 patients who were diagnosed between 1977 and 1995, and group 2 consisted of 18 patients diagnosed between 1996 and 2013. The epidemiology, clinical features, and prognosis were retrospectively compared between the two groups.
Results
The mean number of patients per 100 000 children per year for group 1 and group 2 was 0.33 ± 0.25 and 0.35 ± 0.30, respectively. The duration from onset of symptoms to treatment in group 2 was shorter than that in group 1, but the clinical and laboratory findings at onset did not differ between the two groups. All patients were treated with prednisolone, and 17 patients in group 1 and 18 in group 2 were treated with methylprednisolone pulse therapy. The frequency of cyclophosphamide treatment decreased whereas the frequency of cyclosporine, tacrolimus and mizoribine pulse therapy increased in group 2. SLE disease activity index (SLEDAI) score at the latest follow up in group 2 was lower in group 1. The survival rate was 84% in group 1 and 100% in group 2.
Conclusion
The frequency and severity of SLE in group 1 were similar to those in group 2, and the prognosis of SLE in group 2 was better than that in group 1.</description><subject>Age of Onset</subject><subject>Biopsy</subject><subject>Bredinin</subject><subject>Child</subject><subject>clinical manifestation</subject><subject>epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Forecasting</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Lupus Erythematosus, Systemic - diagnosis</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Male</subject><subject>methylprednisolone</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Survival Rate - trends</subject><subject>systemic lupus erythematosus</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMlOwzAURS0EYigs-AHkJQvSeogTe4lKgVYVUAGCneXEDhgyETeC7Njym3wJ7kC98XvP9z75HgCOMepjfwa10X1MGOdbYB-HIQkIQs_bvqaEBxxF8R44cO4NIcRjHu6CPcIizAQV-0CNy9RqU6YGqlLDuqleyspZB6sMus7NTWFTmLd166BpuvmrKdS8cr6zJVSQst_vn86oBtamsZVeTC_b99a92kKdwYmqVXkIdjKVO3O0vnvg8XL0MLwOprdX4-H5NLCUCB4IriiiLBGpijLBEppFYZgIopIQkYSmWpEsRnGSkoxqbjKmMqKJn3MhtIlC2gOnq70-w0dr3FwW1qUmz1VpqtZJHCOOfWxGvfRkLW2TwmhZN_67TSf_sXjBYCX4tLnpNu8YyQVv6XnLJW95N7pYFt4RrBzWM_vaOFTzLqOYxkw-3VzJezychrPhTE7oH3oWgwc</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Kawasaki, Yukihiko</creator><creator>Ohara, Shinichiro</creator><creator>Miyazaki, Kyohei</creator><creator>Kanno, Shuto</creator><creator>Ono, Atsushi</creator><creator>Suyama, Kazuhide</creator><creator>Sato, Masatoki</creator><creator>Suzuki, Shigeo</creator><creator>Maeda, Ryo</creator><creator>Nagasawa, Katsutoshi</creator><creator>Hosoya, Mitsuaki</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201508</creationdate><title>Incidence and prognosis of systemic lupus erythematosus in a 35 year period in Fukushima, Japan</title><author>Kawasaki, Yukihiko ; Ohara, Shinichiro ; Miyazaki, Kyohei ; Kanno, Shuto ; Ono, Atsushi ; Suyama, Kazuhide ; Sato, Masatoki ; Suzuki, Shigeo ; Maeda, Ryo ; Nagasawa, Katsutoshi ; Hosoya, Mitsuaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3298-98a3035b9ca6f95b3f644b92ab402b3cda2f707bc2f3d8ef5af2d23cd899de643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age of Onset</topic><topic>Biopsy</topic><topic>Bredinin</topic><topic>Child</topic><topic>clinical manifestation</topic><topic>epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Forecasting</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Lupus Erythematosus, Systemic - diagnosis</topic><topic>Lupus Erythematosus, Systemic - epidemiology</topic><topic>Male</topic><topic>methylprednisolone</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Survival Rate - trends</topic><topic>systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawasaki, Yukihiko</creatorcontrib><creatorcontrib>Ohara, Shinichiro</creatorcontrib><creatorcontrib>Miyazaki, Kyohei</creatorcontrib><creatorcontrib>Kanno, Shuto</creatorcontrib><creatorcontrib>Ono, Atsushi</creatorcontrib><creatorcontrib>Suyama, Kazuhide</creatorcontrib><creatorcontrib>Sato, Masatoki</creatorcontrib><creatorcontrib>Suzuki, Shigeo</creatorcontrib><creatorcontrib>Maeda, Ryo</creatorcontrib><creatorcontrib>Nagasawa, Katsutoshi</creatorcontrib><creatorcontrib>Hosoya, Mitsuaki</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawasaki, Yukihiko</au><au>Ohara, Shinichiro</au><au>Miyazaki, Kyohei</au><au>Kanno, Shuto</au><au>Ono, Atsushi</au><au>Suyama, Kazuhide</au><au>Sato, Masatoki</au><au>Suzuki, Shigeo</au><au>Maeda, Ryo</au><au>Nagasawa, Katsutoshi</au><au>Hosoya, Mitsuaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence and prognosis of systemic lupus erythematosus in a 35 year period in Fukushima, Japan</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2015-08</date><risdate>2015</risdate><volume>57</volume><issue>4</issue><spage>650</spage><epage>655</epage><pages>650-655</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background
We examined the epidemiology, clinical manifestations, and prognosis of pediatric systemic lupus erythematosus (SLE) in Fukushima Prefecture, Japan over a 35 year period.
Methods
We collected the medical records of 37 patients diagnosed with SLE between 1977 and 2013. These children were divided into two groups. group 1 consisted of 19 patients who were diagnosed between 1977 and 1995, and group 2 consisted of 18 patients diagnosed between 1996 and 2013. The epidemiology, clinical features, and prognosis were retrospectively compared between the two groups.
Results
The mean number of patients per 100 000 children per year for group 1 and group 2 was 0.33 ± 0.25 and 0.35 ± 0.30, respectively. The duration from onset of symptoms to treatment in group 2 was shorter than that in group 1, but the clinical and laboratory findings at onset did not differ between the two groups. All patients were treated with prednisolone, and 17 patients in group 1 and 18 in group 2 were treated with methylprednisolone pulse therapy. The frequency of cyclophosphamide treatment decreased whereas the frequency of cyclosporine, tacrolimus and mizoribine pulse therapy increased in group 2. SLE disease activity index (SLEDAI) score at the latest follow up in group 2 was lower in group 1. The survival rate was 84% in group 1 and 100% in group 2.
Conclusion
The frequency and severity of SLE in group 1 were similar to those in group 2, and the prognosis of SLE in group 2 was better than that in group 1.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25615939</pmid><doi>10.1111/ped.12588</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age of Onset Biopsy Bredinin Child clinical manifestation epidemiology Female Follow-Up Studies Forecasting Humans Incidence Japan - epidemiology Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - epidemiology Male methylprednisolone Retrospective Studies Severity of Illness Index Survival Rate - trends systemic lupus erythematosus |
| title | Incidence and prognosis of systemic lupus erythematosus in a 35 year period in Fukushima, Japan |
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