Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan
Background:Adverse effects of dietary intake of trans-fatty acids (TFA) on the incidence of coronary artery disease (CAD) are well recognized in Western countries. The risk of TFA, however, has not been well clarified in Japan. We investigated the association of serum TFA concentration with serum li...
Gespeichert in:
| Veröffentlicht in: | Circulation Journal 2015/08/25, Vol.79(9), pp.2017-2025 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2025 |
|---|---|
| container_issue | 9 |
| container_start_page | 2017 |
| container_title | Circulation Journal |
| container_volume | 79 |
| creator | Mori, Kenta Ishida, Tatsuro Yasuda, Tomoyuki Hasokawa, Minoru Monguchi, Tomoko Sasaki, Maki Kondo, Kensuke Nakajima, Hideto Shinohara, Masakazu Shinke, Toshiro Irino, Yasuhiro Toh, Ryuji Nishimura, Kunihiro Hirata, Ken-ichi |
| description | Background:Adverse effects of dietary intake of trans-fatty acids (TFA) on the incidence of coronary artery disease (CAD) are well recognized in Western countries. The risk of TFA, however, has not been well clarified in Japan. We investigated the association of serum TFA concentration with serum lipid profile, coronary risk factors, and prevalence of CAD.Methods and Results:A total of 902 patients, who were hospitalized at Kobe University Hospital from July 2008 to March 2012 and gave written informed consent, were enrolled in this study. Among them, 463 patients had CAD, and 318 patients had metabolic syndrome (MetS). Serum TFA, elaidic acid (trans-9-C18:1) and linolelaidic acid (trans-9, 12-C18:2), were measured on gas chromatography/mass spectrometry. Serum TFA level had a positive correlation with body mass index, waist circumference, low-density lipoprotein cholesterol, triglycerides, and apolipoprotein B48, and an inverse correlation with age and high-density lipoprotein cholesterol. Fasting serum TFA, by age quartile in the young generation with CAD and/or MetS, was higher than that in patients without CAD and/or MetS. On multivariate logistic regression, TFA was identified as a CAD risk after adjustment for classical risk factors.Conclusions:Serum TFA concentration was elevated in young patients with CAD and/or MetS. Diet-derived TFA may cause a serious health problem, particularly in the young generation in Japan. (Circ J 2015; 79: 2017–2025) |
| doi_str_mv | 10.1253/circj.CJ-14-0750 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1708160803</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1708160803</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-3dec599dbb140be70419b1b78ab1b4c12720a187f009e9ee93c5965305603dff3</originalsourceid><addsrcrecordid>eNpFkM1rGzEQxUVpaJw0956Kjr1sOlppP3Q027ixMTSQhJKT0GpnY5m11pW0gf73lWM3ucwbmN97MI-QLwyuWV7w78Z6s71uVhkTGVQFfCAzxkWViTqHj697mcla8HNyEcIWIJdQyE_kPC9ZWQIrZmRzj37a0QevXcgWOsa_dG5sR5vRGXTR62hHR5eB3gz4oiN21Dr6NE7umd6lW0IC_W3jJhn86LRPdh8xyQ8bUAc84Cu91-4zOev1EPDqpJfkcXHz0Nxm618_l818nRkhRcx4h6aQsmtbJqDFCgSTLWurWqcpDMurHDSrqx5AokSUPOFlwaEogXd9zy_Jt2Pu3o9_JgxR7WwwOAza4TgFxSqoWQk18ITCETV-DMFjr_be7tIPioE69Kte-1XNSjGhDv0my9dT-tTusHsz_C80AYsjsA1RP-MboH20ZsBTYiWVPIz35Hdgo71Cx_8BGC-QfQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1708160803</pqid></control><display><type>article</type><title>Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Mori, Kenta ; Ishida, Tatsuro ; Yasuda, Tomoyuki ; Hasokawa, Minoru ; Monguchi, Tomoko ; Sasaki, Maki ; Kondo, Kensuke ; Nakajima, Hideto ; Shinohara, Masakazu ; Shinke, Toshiro ; Irino, Yasuhiro ; Toh, Ryuji ; Nishimura, Kunihiro ; Hirata, Ken-ichi</creator><creatorcontrib>Mori, Kenta ; Ishida, Tatsuro ; Yasuda, Tomoyuki ; Hasokawa, Minoru ; Monguchi, Tomoko ; Sasaki, Maki ; Kondo, Kensuke ; Nakajima, Hideto ; Shinohara, Masakazu ; Shinke, Toshiro ; Irino, Yasuhiro ; Toh, Ryuji ; Nishimura, Kunihiro ; Hirata, Ken-ichi</creatorcontrib><description>Background:Adverse effects of dietary intake of trans-fatty acids (TFA) on the incidence of coronary artery disease (CAD) are well recognized in Western countries. The risk of TFA, however, has not been well clarified in Japan. We investigated the association of serum TFA concentration with serum lipid profile, coronary risk factors, and prevalence of CAD.Methods and Results:A total of 902 patients, who were hospitalized at Kobe University Hospital from July 2008 to March 2012 and gave written informed consent, were enrolled in this study. Among them, 463 patients had CAD, and 318 patients had metabolic syndrome (MetS). Serum TFA, elaidic acid (trans-9-C18:1) and linolelaidic acid (trans-9, 12-C18:2), were measured on gas chromatography/mass spectrometry. Serum TFA level had a positive correlation with body mass index, waist circumference, low-density lipoprotein cholesterol, triglycerides, and apolipoprotein B48, and an inverse correlation with age and high-density lipoprotein cholesterol. Fasting serum TFA, by age quartile in the young generation with CAD and/or MetS, was higher than that in patients without CAD and/or MetS. On multivariate logistic regression, TFA was identified as a CAD risk after adjustment for classical risk factors.Conclusions:Serum TFA concentration was elevated in young patients with CAD and/or MetS. Diet-derived TFA may cause a serious health problem, particularly in the young generation in Japan. (Circ J 2015; 79: 2017–2025)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-14-0750</identifier><identifier>PMID: 26166015</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Age Factors ; Aged ; Cholesterol, HDL - blood ; Coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - chemically induced ; Coronary Artery Disease - epidemiology ; Dietary Fats - adverse effects ; Elaidic acid ; Female ; Humans ; Hyperlipidemia ; Incidence ; Japan - epidemiology ; Male ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - chemically induced ; Metabolic Syndrome - epidemiology ; Middle Aged ; Oleic Acid - blood ; Prevalence ; Trans Fatty Acids - blood ; Trans-fatty acid</subject><ispartof>Circulation Journal, 2015/08/25, Vol.79(9), pp.2017-2025</ispartof><rights>2015 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-3dec599dbb140be70419b1b78ab1b4c12720a187f009e9ee93c5965305603dff3</citedby><cites>FETCH-LOGICAL-c494t-3dec599dbb140be70419b1b78ab1b4c12720a187f009e9ee93c5965305603dff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26166015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mori, Kenta</creatorcontrib><creatorcontrib>Ishida, Tatsuro</creatorcontrib><creatorcontrib>Yasuda, Tomoyuki</creatorcontrib><creatorcontrib>Hasokawa, Minoru</creatorcontrib><creatorcontrib>Monguchi, Tomoko</creatorcontrib><creatorcontrib>Sasaki, Maki</creatorcontrib><creatorcontrib>Kondo, Kensuke</creatorcontrib><creatorcontrib>Nakajima, Hideto</creatorcontrib><creatorcontrib>Shinohara, Masakazu</creatorcontrib><creatorcontrib>Shinke, Toshiro</creatorcontrib><creatorcontrib>Irino, Yasuhiro</creatorcontrib><creatorcontrib>Toh, Ryuji</creatorcontrib><creatorcontrib>Nishimura, Kunihiro</creatorcontrib><creatorcontrib>Hirata, Ken-ichi</creatorcontrib><title>Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background:Adverse effects of dietary intake of trans-fatty acids (TFA) on the incidence of coronary artery disease (CAD) are well recognized in Western countries. The risk of TFA, however, has not been well clarified in Japan. We investigated the association of serum TFA concentration with serum lipid profile, coronary risk factors, and prevalence of CAD.Methods and Results:A total of 902 patients, who were hospitalized at Kobe University Hospital from July 2008 to March 2012 and gave written informed consent, were enrolled in this study. Among them, 463 patients had CAD, and 318 patients had metabolic syndrome (MetS). Serum TFA, elaidic acid (trans-9-C18:1) and linolelaidic acid (trans-9, 12-C18:2), were measured on gas chromatography/mass spectrometry. Serum TFA level had a positive correlation with body mass index, waist circumference, low-density lipoprotein cholesterol, triglycerides, and apolipoprotein B48, and an inverse correlation with age and high-density lipoprotein cholesterol. Fasting serum TFA, by age quartile in the young generation with CAD and/or MetS, was higher than that in patients without CAD and/or MetS. On multivariate logistic regression, TFA was identified as a CAD risk after adjustment for classical risk factors.Conclusions:Serum TFA concentration was elevated in young patients with CAD and/or MetS. Diet-derived TFA may cause a serious health problem, particularly in the young generation in Japan. (Circ J 2015; 79: 2017–2025)</description><subject>Age Factors</subject><subject>Aged</subject><subject>Cholesterol, HDL - blood</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - chemically induced</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Dietary Fats - adverse effects</subject><subject>Elaidic acid</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - chemically induced</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Middle Aged</subject><subject>Oleic Acid - blood</subject><subject>Prevalence</subject><subject>Trans Fatty Acids - blood</subject><subject>Trans-fatty acid</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1rGzEQxUVpaJw0956Kjr1sOlppP3Q027ixMTSQhJKT0GpnY5m11pW0gf73lWM3ucwbmN97MI-QLwyuWV7w78Z6s71uVhkTGVQFfCAzxkWViTqHj697mcla8HNyEcIWIJdQyE_kPC9ZWQIrZmRzj37a0QevXcgWOsa_dG5sR5vRGXTR62hHR5eB3gz4oiN21Dr6NE7umd6lW0IC_W3jJhn86LRPdh8xyQ8bUAc84Cu91-4zOev1EPDqpJfkcXHz0Nxm618_l818nRkhRcx4h6aQsmtbJqDFCgSTLWurWqcpDMurHDSrqx5AokSUPOFlwaEogXd9zy_Jt2Pu3o9_JgxR7WwwOAza4TgFxSqoWQk18ITCETV-DMFjr_be7tIPioE69Kte-1XNSjGhDv0my9dT-tTusHsz_C80AYsjsA1RP-MboH20ZsBTYiWVPIz35Hdgo71Cx_8BGC-QfQ</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Mori, Kenta</creator><creator>Ishida, Tatsuro</creator><creator>Yasuda, Tomoyuki</creator><creator>Hasokawa, Minoru</creator><creator>Monguchi, Tomoko</creator><creator>Sasaki, Maki</creator><creator>Kondo, Kensuke</creator><creator>Nakajima, Hideto</creator><creator>Shinohara, Masakazu</creator><creator>Shinke, Toshiro</creator><creator>Irino, Yasuhiro</creator><creator>Toh, Ryuji</creator><creator>Nishimura, Kunihiro</creator><creator>Hirata, Ken-ichi</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2015</creationdate><title>Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan</title><author>Mori, Kenta ; Ishida, Tatsuro ; Yasuda, Tomoyuki ; Hasokawa, Minoru ; Monguchi, Tomoko ; Sasaki, Maki ; Kondo, Kensuke ; Nakajima, Hideto ; Shinohara, Masakazu ; Shinke, Toshiro ; Irino, Yasuhiro ; Toh, Ryuji ; Nishimura, Kunihiro ; Hirata, Ken-ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-3dec599dbb140be70419b1b78ab1b4c12720a187f009e9ee93c5965305603dff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Cholesterol, HDL - blood</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - chemically induced</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Dietary Fats - adverse effects</topic><topic>Elaidic acid</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperlipidemia</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - chemically induced</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Middle Aged</topic><topic>Oleic Acid - blood</topic><topic>Prevalence</topic><topic>Trans Fatty Acids - blood</topic><topic>Trans-fatty acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mori, Kenta</creatorcontrib><creatorcontrib>Ishida, Tatsuro</creatorcontrib><creatorcontrib>Yasuda, Tomoyuki</creatorcontrib><creatorcontrib>Hasokawa, Minoru</creatorcontrib><creatorcontrib>Monguchi, Tomoko</creatorcontrib><creatorcontrib>Sasaki, Maki</creatorcontrib><creatorcontrib>Kondo, Kensuke</creatorcontrib><creatorcontrib>Nakajima, Hideto</creatorcontrib><creatorcontrib>Shinohara, Masakazu</creatorcontrib><creatorcontrib>Shinke, Toshiro</creatorcontrib><creatorcontrib>Irino, Yasuhiro</creatorcontrib><creatorcontrib>Toh, Ryuji</creatorcontrib><creatorcontrib>Nishimura, Kunihiro</creatorcontrib><creatorcontrib>Hirata, Ken-ichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mori, Kenta</au><au>Ishida, Tatsuro</au><au>Yasuda, Tomoyuki</au><au>Hasokawa, Minoru</au><au>Monguchi, Tomoko</au><au>Sasaki, Maki</au><au>Kondo, Kensuke</au><au>Nakajima, Hideto</au><au>Shinohara, Masakazu</au><au>Shinke, Toshiro</au><au>Irino, Yasuhiro</au><au>Toh, Ryuji</au><au>Nishimura, Kunihiro</au><au>Hirata, Ken-ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2015</date><risdate>2015</risdate><volume>79</volume><issue>9</issue><spage>2017</spage><epage>2025</epage><pages>2017-2025</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background:Adverse effects of dietary intake of trans-fatty acids (TFA) on the incidence of coronary artery disease (CAD) are well recognized in Western countries. The risk of TFA, however, has not been well clarified in Japan. We investigated the association of serum TFA concentration with serum lipid profile, coronary risk factors, and prevalence of CAD.Methods and Results:A total of 902 patients, who were hospitalized at Kobe University Hospital from July 2008 to March 2012 and gave written informed consent, were enrolled in this study. Among them, 463 patients had CAD, and 318 patients had metabolic syndrome (MetS). Serum TFA, elaidic acid (trans-9-C18:1) and linolelaidic acid (trans-9, 12-C18:2), were measured on gas chromatography/mass spectrometry. Serum TFA level had a positive correlation with body mass index, waist circumference, low-density lipoprotein cholesterol, triglycerides, and apolipoprotein B48, and an inverse correlation with age and high-density lipoprotein cholesterol. Fasting serum TFA, by age quartile in the young generation with CAD and/or MetS, was higher than that in patients without CAD and/or MetS. On multivariate logistic regression, TFA was identified as a CAD risk after adjustment for classical risk factors.Conclusions:Serum TFA concentration was elevated in young patients with CAD and/or MetS. Diet-derived TFA may cause a serious health problem, particularly in the young generation in Japan. (Circ J 2015; 79: 2017–2025)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>26166015</pmid><doi>10.1253/circj.CJ-14-0750</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1346-9843 |
| ispartof | Circulation Journal, 2015/08/25, Vol.79(9), pp.2017-2025 |
| issn | 1346-9843 1347-4820 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1708160803 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Age Factors Aged Cholesterol, HDL - blood Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - chemically induced Coronary Artery Disease - epidemiology Dietary Fats - adverse effects Elaidic acid Female Humans Hyperlipidemia Incidence Japan - epidemiology Male Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - chemically induced Metabolic Syndrome - epidemiology Middle Aged Oleic Acid - blood Prevalence Trans Fatty Acids - blood Trans-fatty acid |
| title | Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T03%3A47%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20Trans-Fatty%20Acid%20Concentration%20Is%20Elevated%20in%20Young%20Patients%20With%20Coronary%20Artery%20Disease%20in%20Japan&rft.jtitle=Circulation%20Journal&rft.au=Mori,%20Kenta&rft.date=2015&rft.volume=79&rft.issue=9&rft.spage=2017&rft.epage=2025&rft.pages=2017-2025&rft.issn=1346-9843&rft.eissn=1347-4820&rft_id=info:doi/10.1253/circj.CJ-14-0750&rft_dat=%3Cproquest_cross%3E1708160803%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1708160803&rft_id=info:pmid/26166015&rfr_iscdi=true |