Phagocyte subsets and lymphocyte clonal deletion behind ineffective immune response to Staphylococcus aureus

Lack of known mechanisms of protection against Staphylococcus aureus in humans is hindering development of efficacious vaccines. Preclinical as well as clinical data suggest that antibodies play an important role against S. aureus. For instance, certain hypogammaglobulinaemic patients are at increas...

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Veröffentlicht in:	FEMS microbiology reviews 2015-09, Vol.39 (5), p.750-763
Hauptverfasser:	Pozzi, Clarissa, Lofano, Giuseppe, Mancini, Francesca, Soldaini, Elisabetta, Speziale, Pietro, De Gregorio, Ennio, Rappuoli, Rino, Bertholet, Sylvie, Grandi, Guido, Bagnoli, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Anergy Antibodies Antigens Bacteremia Biofilms CD4 antigen Cell activation Cell proliferation Clonal Deletion Cytokines Extravasation Humans Immune clearance Immune Evasion Immune response Immune response (humoral) Immune system Leukocytes (neutrophilic) Lymphocytes Lymphocytes - cytology Lymphocytes - immunology Lymphocytes B Lymphocytes T Macrophages Neutrophils Penicillin Phagocytes - immunology Protein A Risk analysis Risk factors Sepsis Staphylococcal Infections - immunology Staphylococcus aureus Staphylococcus aureus - immunology Vaccines
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