Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal
The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place prefere...
Gespeichert in:
| Veröffentlicht in: | Neuroscience 2006, Vol.138 (1), p.77-82 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 82 |
|---|---|
| container_issue | 1 |
| container_start_page | 77 |
| container_title | Neuroscience |
| container_volume | 138 |
| creator | Sun, N. Li, Y. Tian, S. Lei, Y. Zheng, J. Yang, J. Sui, N. Xu, L. Pei, G. Wilson, F.A.W. Ma, Y. Lei, H. Hu, X. |
| description | The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place preference paradigm, using manganese-enhanced magnetic resonance imaging and traditional electroencephalograph recording techniques in rats. T1-weighted 2D MRI (4.7 T) was used after unilateral injection of MnCl
2 (200nL, 80mM) into the right orbitofrontal cortex. The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period. Also, we found decreases and increases in gamma-band (20–100Hz) activity during the opiate administration and withdrawal period, respectively. Our results showed that orbitofrontal cortex activity decreased during morphine administration and then went up progressively over several days during withdrawal. The time course of the recovery of orbitofrontal activity from inhibition during the withdrawal period may be related to the experience of drug craving. |
| doi_str_mv | 10.1016/j.neuroscience.2005.10.034 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17080922</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0306452205011930</els_id><sourcerecordid>17080922</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-50abb48344244a963bceed0ec77b647a4a8d08089416f35326ed63b698c56e3a3</originalsourceid><addsrcrecordid>eNqNkMFu1DAURS0EokPhF5CFRHeZOrFjJ-xQW6BSJTawtl7sl9ajxB5sp9X8fT1MpLLEG1u65_o9HUI-1Wxbs1pe7rYelxiScegNbhvG2hJsGRevyKbuFK9UK8RrsmGcyUq0TXNG3qW0Y-W0gr8lZ7XkSrG-2ZDx-uBhdoaaB_D3mKjzNMTB5TDG4DNM9O8sXx5gsnt0-XBEIuRE7RKdv6dh7yAjBTs771IukQuegrf0yeUHG-EJpvfkzQhTwg_rfU5-f7v5dfWjuvv5_fbq611lBO9z1TIYBtFxIRohoJd8MIiWoVFqkEKBgM6yjnW9qOXIW95ItAWSfWdaiRz4Obk4_buP4c-CKevZJYPTBB7DknStSr1vmgJ-OYGmiEwRR72PboZ40DXTR8t6p_-1rI-Wj1mxXMof1ynLMKN9qa5aC_B5BSAZmMYI3rj0wilZ932jCnd94rA4eXQY9TrOuogmaxvc_-zzDNDTpAo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17080922</pqid></control><display><type>article</type><title>Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Sun, N. ; Li, Y. ; Tian, S. ; Lei, Y. ; Zheng, J. ; Yang, J. ; Sui, N. ; Xu, L. ; Pei, G. ; Wilson, F.A.W. ; Ma, Y. ; Lei, H. ; Hu, X.</creator><creatorcontrib>Sun, N. ; Li, Y. ; Tian, S. ; Lei, Y. ; Zheng, J. ; Yang, J. ; Sui, N. ; Xu, L. ; Pei, G. ; Wilson, F.A.W. ; Ma, Y. ; Lei, H. ; Hu, X.</creatorcontrib><description>The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place preference paradigm, using manganese-enhanced magnetic resonance imaging and traditional electroencephalograph recording techniques in rats. T1-weighted 2D MRI (4.7 T) was used after unilateral injection of MnCl
2 (200nL, 80mM) into the right orbitofrontal cortex. The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period. Also, we found decreases and increases in gamma-band (20–100Hz) activity during the opiate administration and withdrawal period, respectively. Our results showed that orbitofrontal cortex activity decreased during morphine administration and then went up progressively over several days during withdrawal. The time course of the recovery of orbitofrontal activity from inhibition during the withdrawal period may be related to the experience of drug craving.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2005.10.034</identifier><identifier>PMID: 16377092</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; conditioned place preference ; Conditioning, Operant - drug effects ; drug craving ; Electroencephalography ; Fundamental and applied biological sciences. Psychology ; gamma-band EEG ; Magnetic Resonance Imaging ; Male ; Manganese ; manganese-enhanced MRI ; Morphine - pharmacology ; Narcotics - pharmacology ; Neurons - drug effects ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - physiopathology ; Rats ; Rats, Sprague-Dawley ; Stereotaxic Techniques ; Substance Withdrawal Syndrome - physiopathology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2006, Vol.138 (1), p.77-82</ispartof><rights>2005 IBRO</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-50abb48344244a963bceed0ec77b647a4a8d08089416f35326ed63b698c56e3a3</citedby><cites>FETCH-LOGICAL-c439t-50abb48344244a963bceed0ec77b647a4a8d08089416f35326ed63b698c56e3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306452205011930$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17619927$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16377092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, N.</creatorcontrib><creatorcontrib>Li, Y.</creatorcontrib><creatorcontrib>Tian, S.</creatorcontrib><creatorcontrib>Lei, Y.</creatorcontrib><creatorcontrib>Zheng, J.</creatorcontrib><creatorcontrib>Yang, J.</creatorcontrib><creatorcontrib>Sui, N.</creatorcontrib><creatorcontrib>Xu, L.</creatorcontrib><creatorcontrib>Pei, G.</creatorcontrib><creatorcontrib>Wilson, F.A.W.</creatorcontrib><creatorcontrib>Ma, Y.</creatorcontrib><creatorcontrib>Lei, H.</creatorcontrib><creatorcontrib>Hu, X.</creatorcontrib><title>Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place preference paradigm, using manganese-enhanced magnetic resonance imaging and traditional electroencephalograph recording techniques in rats. T1-weighted 2D MRI (4.7 T) was used after unilateral injection of MnCl
2 (200nL, 80mM) into the right orbitofrontal cortex. The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period. Also, we found decreases and increases in gamma-band (20–100Hz) activity during the opiate administration and withdrawal period, respectively. Our results showed that orbitofrontal cortex activity decreased during morphine administration and then went up progressively over several days during withdrawal. The time course of the recovery of orbitofrontal activity from inhibition during the withdrawal period may be related to the experience of drug craving.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>conditioned place preference</subject><subject>Conditioning, Operant - drug effects</subject><subject>drug craving</subject><subject>Electroencephalography</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-band EEG</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Manganese</subject><subject>manganese-enhanced MRI</subject><subject>Morphine - pharmacology</subject><subject>Narcotics - pharmacology</subject><subject>Neurons - drug effects</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stereotaxic Techniques</subject><subject>Substance Withdrawal Syndrome - physiopathology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAURS0EokPhF5CFRHeZOrFjJ-xQW6BSJTawtl7sl9ajxB5sp9X8fT1MpLLEG1u65_o9HUI-1Wxbs1pe7rYelxiScegNbhvG2hJsGRevyKbuFK9UK8RrsmGcyUq0TXNG3qW0Y-W0gr8lZ7XkSrG-2ZDx-uBhdoaaB_D3mKjzNMTB5TDG4DNM9O8sXx5gsnt0-XBEIuRE7RKdv6dh7yAjBTs771IukQuegrf0yeUHG-EJpvfkzQhTwg_rfU5-f7v5dfWjuvv5_fbq611lBO9z1TIYBtFxIRohoJd8MIiWoVFqkEKBgM6yjnW9qOXIW95ItAWSfWdaiRz4Obk4_buP4c-CKevZJYPTBB7DknStSr1vmgJ-OYGmiEwRR72PboZ40DXTR8t6p_-1rI-Wj1mxXMof1ynLMKN9qa5aC_B5BSAZmMYI3rj0wilZ932jCnd94rA4eXQY9TrOuogmaxvc_-zzDNDTpAo</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Sun, N.</creator><creator>Li, Y.</creator><creator>Tian, S.</creator><creator>Lei, Y.</creator><creator>Zheng, J.</creator><creator>Yang, J.</creator><creator>Sui, N.</creator><creator>Xu, L.</creator><creator>Pei, G.</creator><creator>Wilson, F.A.W.</creator><creator>Ma, Y.</creator><creator>Lei, H.</creator><creator>Hu, X.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>2006</creationdate><title>Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal</title><author>Sun, N. ; Li, Y. ; Tian, S. ; Lei, Y. ; Zheng, J. ; Yang, J. ; Sui, N. ; Xu, L. ; Pei, G. ; Wilson, F.A.W. ; Ma, Y. ; Lei, H. ; Hu, X.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-50abb48344244a963bceed0ec77b647a4a8d08089416f35326ed63b698c56e3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>conditioned place preference</topic><topic>Conditioning, Operant - drug effects</topic><topic>drug craving</topic><topic>Electroencephalography</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-band EEG</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Manganese</topic><topic>manganese-enhanced MRI</topic><topic>Morphine - pharmacology</topic><topic>Narcotics - pharmacology</topic><topic>Neurons - drug effects</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Stereotaxic Techniques</topic><topic>Substance Withdrawal Syndrome - physiopathology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, N.</creatorcontrib><creatorcontrib>Li, Y.</creatorcontrib><creatorcontrib>Tian, S.</creatorcontrib><creatorcontrib>Lei, Y.</creatorcontrib><creatorcontrib>Zheng, J.</creatorcontrib><creatorcontrib>Yang, J.</creatorcontrib><creatorcontrib>Sui, N.</creatorcontrib><creatorcontrib>Xu, L.</creatorcontrib><creatorcontrib>Pei, G.</creatorcontrib><creatorcontrib>Wilson, F.A.W.</creatorcontrib><creatorcontrib>Ma, Y.</creatorcontrib><creatorcontrib>Lei, H.</creatorcontrib><creatorcontrib>Hu, X.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, N.</au><au>Li, Y.</au><au>Tian, S.</au><au>Lei, Y.</au><au>Zheng, J.</au><au>Yang, J.</au><au>Sui, N.</au><au>Xu, L.</au><au>Pei, G.</au><au>Wilson, F.A.W.</au><au>Ma, Y.</au><au>Lei, H.</au><au>Hu, X.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2006</date><risdate>2006</risdate><volume>138</volume><issue>1</issue><spage>77</spage><epage>82</epage><pages>77-82</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place preference paradigm, using manganese-enhanced magnetic resonance imaging and traditional electroencephalograph recording techniques in rats. T1-weighted 2D MRI (4.7 T) was used after unilateral injection of MnCl
2 (200nL, 80mM) into the right orbitofrontal cortex. The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period. Also, we found decreases and increases in gamma-band (20–100Hz) activity during the opiate administration and withdrawal period, respectively. Our results showed that orbitofrontal cortex activity decreased during morphine administration and then went up progressively over several days during withdrawal. The time course of the recovery of orbitofrontal activity from inhibition during the withdrawal period may be related to the experience of drug craving.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16377092</pmid><doi>10.1016/j.neuroscience.2005.10.034</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 2006, Vol.138 (1), p.77-82 |
| issn | 0306-4522 1873-7544 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17080922 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences conditioned place preference Conditioning, Operant - drug effects drug craving Electroencephalography Fundamental and applied biological sciences. Psychology gamma-band EEG Magnetic Resonance Imaging Male Manganese manganese-enhanced MRI Morphine - pharmacology Narcotics - pharmacology Neurons - drug effects Prefrontal Cortex - drug effects Prefrontal Cortex - physiopathology Rats Rats, Sprague-Dawley Stereotaxic Techniques Substance Withdrawal Syndrome - physiopathology Vertebrates: nervous system and sense organs |
| title | Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T04%3A48%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dynamic%20changes%20in%20orbitofrontal%20neuronal%20activity%20in%20rats%20during%20opiate%20administration%20and%20withdrawal&rft.jtitle=Neuroscience&rft.au=Sun,%20N.&rft.date=2006&rft.volume=138&rft.issue=1&rft.spage=77&rft.epage=82&rft.pages=77-82&rft.issn=0306-4522&rft.eissn=1873-7544&rft.coden=NRSCDN&rft_id=info:doi/10.1016/j.neuroscience.2005.10.034&rft_dat=%3Cproquest_cross%3E17080922%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17080922&rft_id=info:pmid/16377092&rft_els_id=S0306452205011930&rfr_iscdi=true |