Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins

Tea phenolic acids and catechins containing gallic acid moieties are most abundant in green tea, and various medical benefits have been proposed from their consumption. In the following, the cytotoxicities of these major tea phenolics toward isolated rat hepatocytes have been ranked and the mechanis...

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Veröffentlicht in:	Free radical biology & medicine 2006-02, Vol.40 (4), p.570-580
Hauptverfasser:	Galati, Giuseppe, Lin, Alison, Sultan, Amira M., O'Brien, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Antioxidants - toxicity Catechin - analogs & derivatives Catechin - toxicity Cytotoxicity Flavonoids Free radicals Gallic Acid - toxicity Glutathione - metabolism GSH conjugates Hepatocytes Hydroxybenzoates - toxicity Iron - metabolism Liver - drug effects Male Mass Spectrometry Methylation Mice NAD(P)H Dehydrogenase (Quinone) - genetics NAD(P)H Dehydrogenase (Quinone) - metabolism Phenolic acids Rats Rats, Sprague-Dawley Tea - chemistry
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