IL-10 cooperates with TNF-alpha to activate HIV-1 from latently and acutely infected cells of monocyte/macrophage lineage

IL-10 is elevated in HIV-1-infected individuals and has been implicated in disease progression. In this study, we investigated the effects of IL-10 on the activation of HIV-1 from infected monocytes and macrophages. Although IL-10 alone did not induce HIV-1 replication, in the presence of TNF-alpha,...

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Veröffentlicht in:	The Journal of immunology (1950) 1996-01, Vol.156 (2), p.841-851
Hauptverfasser:	Finnegan, A, Roebuck, KA, Nakai, BE, Gu, DS, Rabbi, MF, Song, S, Landay, AL
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Drug Synergism Gene Expression Regulation, Viral - drug effects HIV Long Terminal Repeat HIV-1 - drug effects HIV-1 - growth & development human immunodeficiency virus Humans Interleukin-10 - pharmacology Lymphoma, Large B-Cell, Diffuse - pathology Macrophages - virology Molecular Sequence Data Monocytes - virology NF-kappa B - metabolism Recombinant Fusion Proteins - pharmacology RNA, Messenger - biosynthesis RNA, Viral - biosynthesis Transcription Factor AP-1 - metabolism Transcription, Genetic - drug effects Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology Virus Activation - drug effects Virus Latency Virus Replication
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