Thyroid receptor ligands. Part 5: Novel bicyclic agonist ligands selective for the thyroid hormone receptor β

Based on the examination of the crystal structure of rat TRβ complexed with 3,5,3′-triiodo- l-thyronine ( 2), a novel TRβ-selective indole derivative 6b was prepared and tested in vitro. Its β-selectivity could be rationalized through the comparison of the X-ray crystallographic structures of 6b com...

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