Duocarmycins, Potent Antitumor Antibiotics Produced by Streptomyces sp. Structures and Chemistry

Seven novel potent antitumor antibiotics, duocarmycins A (1), C1 (2), C2 (3), D (4), B1 (5), B2 (6) and SA (7), were isolated from three independently collected Streptomyces sp. The complete structures, including absolute stereochemistry, were determined by spectral and chemical studies of those duo...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1995/03/15, Vol.43(3), pp.378-391
Hauptverfasser:	YASUZAWA, Tohru, MUROI, Ken'ichi, ICHIMURA, Michio, TAKAHASHI, Isami, OGAWA, Tatsuhiro, TAKAHASHI, Keiichi, SANO, Hiroshi, SAITOH, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - chemistry Alkylating Agents - metabolism Alkylating Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, Antineoplastic - biosynthesis Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents antitumor antibiotic Applied microbiology Biological and medical sciences Chemical Phenomena Chemistry, Physical duocarmycin exciton chirality Fundamental and applied biological sciences. Psychology Indoles Magnetic Resonance Spectroscopy Microbiology Molecular Structure Pyrrolidinones - chemistry Pyrrolidinones - metabolism Pyrrolidinones - pharmacology Stereoisomerism Streptomyces Streptomyces - chemistry Streptomyces - metabolism Streptomyces sp
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