Ethanol potentiates valproic acid-induced neural tube defects (NTDs) in mice due to toxicokinetic interactions

Both the antiepileptic drug valproic acid (VPA) and ethanol interfere with fetal folate metabolism, which may contribute to their mechanism of teratogenesis. Therefore, the possible interaction between VPA and ethanol was investigated in mice. Ethanol (2 × 2.5 g/kg) was given orally 4 and 1 h prior...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 1995-09, Vol.9 (5), p.427-433
Hauptverfasser:	Elmazar, Mohamed M.A., Nau, Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - etiology Animals Anticonvulsants - toxicity Biological and medical sciences Brain - abnormalities Drug Synergism Drug toxicity and drugs side effects treatment ethanol Ethanol - administration & dosage Ethanol - toxicity Female Fetal Death - chemically induced Intubation, Gastrointestinal Medical sciences Mice Miscellaneous (drug allergy, mutagens, teratogens...) neural tube defects Neural Tube Defects - chemically induced Pharmacology. Drug treatments Pregnancy pregnant mice toxicokinetic interactions valproic acid Valproic Acid - blood Valproic Acid - toxicity
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