Reduced amount of olfactory receptor neurons in the rat model of depression
•Atrophic olfactory epithelium presents in the CUMS rat model.•Reduced number of basal cells is shown in the olfactory epithelium of CUMS rat model.•Reduced number of immature olfactory receptor neurons is shown in the olfactory epithelium of CUMS rat model.•Reduced number of mature olfactory recept...
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| Veröffentlicht in: | Neuroscience letters 2015-08, Vol.603, p.48-54 |
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| creator | Li, Qianlu Yang, Deyu Wang, Juan Liu, Li Feng, Guibo Li, Juan Liao, Juan Wei, Youdong Li, Zhiwei |
| description | •Atrophic olfactory epithelium presents in the CUMS rat model.•Reduced number of basal cells is shown in the olfactory epithelium of CUMS rat model.•Reduced number of immature olfactory receptor neurons is shown in the olfactory epithelium of CUMS rat model.•Reduced number of mature olfactory receptor neurons is shown in the olfactory epithelium of CUMS rat model.
Reduced olfactory sensitivity has been reported in depressive disorder. However, the pathological mechanism is still unclear. The reduced olfactory bulb (OB) volume and reduced hippocampal neurogenesis has been unraveled in major depressive disorder (MDD). However, changes in olfactory epithelium (OE) have not been reported, which might contribute to olfactory deficits in MDD. In the context, we investigated the thickness of OE in a chronic unpredictable mild stress (CUMS) rat model of depression using hematoxylin and eosin (HE) staining. Simultaneously, the basal cells (labeled by nerve growth factor receptor (p75NGFR)), immature olfactory receptor neurons (ORNs) (marked by growth-associated protein 43 (GAP43)) and mature ORNs (labeled by olfactory marker protein (OMP)) in OE were detected by immunohistochemistry. The results showed that the thickness of OE, the number of basal cells, immature ORNs as well as mature ORNs decreased dramatically in the OE of CUMS rats. Those findings indicate that the reduced number of ORNs might induce OE atrophy in CUMS rats and the abnormalities of the OE may be partially responsible for the reduced olfactory sensitivity in MDD. |
| doi_str_mv | 10.1016/j.neulet.2015.07.007 |
| format | Article |
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Reduced olfactory sensitivity has been reported in depressive disorder. However, the pathological mechanism is still unclear. The reduced olfactory bulb (OB) volume and reduced hippocampal neurogenesis has been unraveled in major depressive disorder (MDD). However, changes in olfactory epithelium (OE) have not been reported, which might contribute to olfactory deficits in MDD. In the context, we investigated the thickness of OE in a chronic unpredictable mild stress (CUMS) rat model of depression using hematoxylin and eosin (HE) staining. Simultaneously, the basal cells (labeled by nerve growth factor receptor (p75NGFR)), immature olfactory receptor neurons (ORNs) (marked by growth-associated protein 43 (GAP43)) and mature ORNs (labeled by olfactory marker protein (OMP)) in OE were detected by immunohistochemistry. The results showed that the thickness of OE, the number of basal cells, immature ORNs as well as mature ORNs decreased dramatically in the OE of CUMS rats. Those findings indicate that the reduced number of ORNs might induce OE atrophy in CUMS rats and the abnormalities of the OE may be partially responsible for the reduced olfactory sensitivity in MDD.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2015.07.007</identifier><identifier>PMID: 26170245</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Cell Count ; Depressive Disorder, Major - etiology ; Depressive Disorder, Major - metabolism ; Depressive Disorder, Major - pathology ; GAP-43 Protein - metabolism ; Major depressive disorder ; Male ; Olfactory deficits ; Olfactory epithelium ; Olfactory Marker Protein - metabolism ; Olfactory Mucosa - metabolism ; Olfactory Mucosa - pathology ; Olfactory receptor neurons ; Olfactory Receptor Neurons - metabolism ; Olfactory Receptor Neurons - pathology ; Rats, Sprague-Dawley ; Receptors, Nerve Growth Factor - metabolism ; Stress, Psychological - complications</subject><ispartof>Neuroscience letters, 2015-08, Vol.603, p.48-54</ispartof><rights>2015 Elsevier Ireland Ltd</rights><rights>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-873a9e68b905ec3e5910718185c3cdcc08d5acf37d5a2f4731d88a4f5c1322fa3</citedby><cites>FETCH-LOGICAL-c428t-873a9e68b905ec3e5910718185c3cdcc08d5acf37d5a2f4731d88a4f5c1322fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2015.07.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26170245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Qianlu</creatorcontrib><creatorcontrib>Yang, Deyu</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Feng, Guibo</creatorcontrib><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Liao, Juan</creatorcontrib><creatorcontrib>Wei, Youdong</creatorcontrib><creatorcontrib>Li, Zhiwei</creatorcontrib><title>Reduced amount of olfactory receptor neurons in the rat model of depression</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>•Atrophic olfactory epithelium presents in the CUMS rat model.•Reduced number of basal cells is shown in the olfactory epithelium of CUMS rat model.•Reduced number of immature olfactory receptor neurons is shown in the olfactory epithelium of CUMS rat model.•Reduced number of mature olfactory receptor neurons is shown in the olfactory epithelium of CUMS rat model.
Reduced olfactory sensitivity has been reported in depressive disorder. However, the pathological mechanism is still unclear. The reduced olfactory bulb (OB) volume and reduced hippocampal neurogenesis has been unraveled in major depressive disorder (MDD). However, changes in olfactory epithelium (OE) have not been reported, which might contribute to olfactory deficits in MDD. In the context, we investigated the thickness of OE in a chronic unpredictable mild stress (CUMS) rat model of depression using hematoxylin and eosin (HE) staining. Simultaneously, the basal cells (labeled by nerve growth factor receptor (p75NGFR)), immature olfactory receptor neurons (ORNs) (marked by growth-associated protein 43 (GAP43)) and mature ORNs (labeled by olfactory marker protein (OMP)) in OE were detected by immunohistochemistry. The results showed that the thickness of OE, the number of basal cells, immature ORNs as well as mature ORNs decreased dramatically in the OE of CUMS rats. Those findings indicate that the reduced number of ORNs might induce OE atrophy in CUMS rats and the abnormalities of the OE may be partially responsible for the reduced olfactory sensitivity in MDD.</description><subject>Animals</subject><subject>Cell Count</subject><subject>Depressive Disorder, Major - etiology</subject><subject>Depressive Disorder, Major - metabolism</subject><subject>Depressive Disorder, Major - pathology</subject><subject>GAP-43 Protein - metabolism</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Olfactory deficits</subject><subject>Olfactory epithelium</subject><subject>Olfactory Marker Protein - metabolism</subject><subject>Olfactory Mucosa - metabolism</subject><subject>Olfactory Mucosa - pathology</subject><subject>Olfactory receptor neurons</subject><subject>Olfactory Receptor Neurons - metabolism</subject><subject>Olfactory Receptor Neurons - pathology</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Nerve Growth Factor - metabolism</subject><subject>Stress, Psychological - complications</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVJqF2n_yAEHXPZ7ejL0l4CwSRpqaEQ2rOQpVm6ZnflSLuB_PvIOMkxp5nD887LPIRcMqgZsPWPfT3i3ONUc2CqBl0D6C9kyYzmlW40PyNLECAr0UhYkG857wFAMSW_kgVfMw1cqiX5_Yhh9hioG-I8TjS2NPat81NMLzShx0PZaGlKccy0G-n0H2lyEx1iwP6IBzwkzLmL4wU5b12f8fvbXJF_93d_Nz-r7Z-HX5vbbeUlN1NltHANrs2uAYVeoGoYaGaYUV744D2YoJxvhS6Dt1ILFoxxslWeCc5bJ1bk-nT3kOLTjHmyQ5c99r0bMc7Zlt-0UlquVUHlCfUp5pywtYfUDS69WAb2qNHu7UmjPWq0oG3RWGJXbw3zbsDwEXr3VoCbE4Dlz-cOk82-w7GI7Iq0yYbYfd7wCnPJhao</recordid><startdate>20150831</startdate><enddate>20150831</enddate><creator>Li, Qianlu</creator><creator>Yang, Deyu</creator><creator>Wang, Juan</creator><creator>Liu, Li</creator><creator>Feng, Guibo</creator><creator>Li, Juan</creator><creator>Liao, Juan</creator><creator>Wei, Youdong</creator><creator>Li, Zhiwei</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150831</creationdate><title>Reduced amount of olfactory receptor neurons in the rat model of depression</title><author>Li, Qianlu ; Yang, Deyu ; Wang, Juan ; Liu, Li ; Feng, Guibo ; Li, Juan ; Liao, Juan ; Wei, Youdong ; Li, Zhiwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-873a9e68b905ec3e5910718185c3cdcc08d5acf37d5a2f4731d88a4f5c1322fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Cell Count</topic><topic>Depressive Disorder, Major - etiology</topic><topic>Depressive Disorder, Major - metabolism</topic><topic>Depressive Disorder, Major - pathology</topic><topic>GAP-43 Protein - metabolism</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Olfactory deficits</topic><topic>Olfactory epithelium</topic><topic>Olfactory Marker Protein - metabolism</topic><topic>Olfactory Mucosa - metabolism</topic><topic>Olfactory Mucosa - pathology</topic><topic>Olfactory receptor neurons</topic><topic>Olfactory Receptor Neurons - metabolism</topic><topic>Olfactory Receptor Neurons - pathology</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Nerve Growth Factor - metabolism</topic><topic>Stress, Psychological - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Qianlu</creatorcontrib><creatorcontrib>Yang, Deyu</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Feng, Guibo</creatorcontrib><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Liao, Juan</creatorcontrib><creatorcontrib>Wei, Youdong</creatorcontrib><creatorcontrib>Li, Zhiwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Qianlu</au><au>Yang, Deyu</au><au>Wang, Juan</au><au>Liu, Li</au><au>Feng, Guibo</au><au>Li, Juan</au><au>Liao, Juan</au><au>Wei, Youdong</au><au>Li, Zhiwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced amount of olfactory receptor neurons in the rat model of depression</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2015-08-31</date><risdate>2015</risdate><volume>603</volume><spage>48</spage><epage>54</epage><pages>48-54</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>•Atrophic olfactory epithelium presents in the CUMS rat model.•Reduced number of basal cells is shown in the olfactory epithelium of CUMS rat model.•Reduced number of immature olfactory receptor neurons is shown in the olfactory epithelium of CUMS rat model.•Reduced number of mature olfactory receptor neurons is shown in the olfactory epithelium of CUMS rat model.
Reduced olfactory sensitivity has been reported in depressive disorder. However, the pathological mechanism is still unclear. The reduced olfactory bulb (OB) volume and reduced hippocampal neurogenesis has been unraveled in major depressive disorder (MDD). However, changes in olfactory epithelium (OE) have not been reported, which might contribute to olfactory deficits in MDD. In the context, we investigated the thickness of OE in a chronic unpredictable mild stress (CUMS) rat model of depression using hematoxylin and eosin (HE) staining. Simultaneously, the basal cells (labeled by nerve growth factor receptor (p75NGFR)), immature olfactory receptor neurons (ORNs) (marked by growth-associated protein 43 (GAP43)) and mature ORNs (labeled by olfactory marker protein (OMP)) in OE were detected by immunohistochemistry. The results showed that the thickness of OE, the number of basal cells, immature ORNs as well as mature ORNs decreased dramatically in the OE of CUMS rats. Those findings indicate that the reduced number of ORNs might induce OE atrophy in CUMS rats and the abnormalities of the OE may be partially responsible for the reduced olfactory sensitivity in MDD.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>26170245</pmid><doi>10.1016/j.neulet.2015.07.007</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Cell Count Depressive Disorder, Major - etiology Depressive Disorder, Major - metabolism Depressive Disorder, Major - pathology GAP-43 Protein - metabolism Major depressive disorder Male Olfactory deficits Olfactory epithelium Olfactory Marker Protein - metabolism Olfactory Mucosa - metabolism Olfactory Mucosa - pathology Olfactory receptor neurons Olfactory Receptor Neurons - metabolism Olfactory Receptor Neurons - pathology Rats, Sprague-Dawley Receptors, Nerve Growth Factor - metabolism Stress, Psychological - complications |
| title | Reduced amount of olfactory receptor neurons in the rat model of depression |
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