Serum omentin, resistin and tumour necrosis factor-α levels in Behcet patients with and without ocular involvement
Purpose The objective of this study was to evaluate serum omentin, resistin and tumour necrosis factor-α (TNF-α) levels in Behcet disease (BD) patients with and without ocular involvement, as well as control subjects. Methods Omentin, resistin and TNF-α levels were assessed in the plasma of 51 BD pa...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2015-09, Vol.253 (9), p.1565-1568 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
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| creator | Türkcü, Fatih Mehmet Şahin, Alparslan Cingü, Abdullah Kürşat Kaya, Savaş Yüksel, Hatice Cinar, Yasin Batmaz, İbrahim |
| description | Purpose
The objective of this study was to evaluate serum omentin, resistin and tumour necrosis factor-α (TNF-α) levels in Behcet disease (BD) patients with and without ocular involvement, as well as control subjects.
Methods
Omentin, resistin and TNF-α levels were assessed in the plasma of 51 BD patients and compared with those of 24 control subjects.
Results
The plasma resistin and TNF-α levels were significantly higher in the BD patients than in the control group (
p
= 0.028 and
p
= 0.011, respectively), whereas the plasma omentin level was significantly lower in BD patients than in the control group (
p
= 0.035). In the ocular BD, non-ocular BD and control groups, the omentin levels were 8.9 ± 4.65, 8.6 ± 3.61, and 12.4 ± 6.24 ng/mL; resistin levels were 0.29 ± 0.21, 0.24 ± 0.2 and 0.15 ± 0.45 ng/mL; and TNF-α levels were 25.45 ± 3.65, 24.03 ± 2.49 and 21.93 ± 4.86 ng/mL, respectively. Omentin/resistin and TNF-α/omentin ratios were more significant parameters in the demonstration of the differences in the groups; the former was lower and the latter was higher in the patient groups (
p
= 0.001 and
p
= 0.002, respectively).
Conclusions
We demonstrated that the plasma omentin level and omentin/resistin ratio were decreased, whereas the resistin and TNF-α levels and TNF-α/omentin ratio were increased in BD patients. These ratios may be used in the presentation of deviation in the inflammatory and anti-inflammatory balance in BD. |
| doi_str_mv | 10.1007/s00417-015-3016-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1707555067</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1707555067</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-e3103e35068f9c8498d160643b8cbf79d63fe86fa514f1a150dd762be64cdb303</originalsourceid><addsrcrecordid>eNp9kM1u1TAQRi0EopfCA7BBXrLAdCa242QJVfmRKrEApO4sx5nQVEl8sZ2L-li8SJ8Jh1tYdjWj8ZnPmsPYS4S3CGDOEoBCIwC1kIC1gEdsh0pqYaC6esx2YCoUjayuTtizlG6g4FLjU3ZS6RZU1TY7lr5SXGceZlryuLzhkdKYSsfd0vO8zmGNfCEfQxnzwfkcorj7zSc60JR44d7TtafM9y6PJSLxX2O-_ru8NWHNPPh1crGghzAdaPvnOXsyuCnRi_t6yr5_uPh2_klcfvn4-fzdpfAKVRYkESRJDXUztL5RbdNjDbWSXeO7wbR9LQdq6sFpVAM61ND3pq46qpXvOwnylL0-5u5j-LlSynYek6dpcguFNVk0YLQu-aageES3S1Okwe7jOLt4axHs5toeXdvi2m6u7Rb_6j5-7Wbq_2_8k1uA6gik8rT8oGhvis6lnPxA6h8OAow6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1707555067</pqid></control><display><type>article</type><title>Serum omentin, resistin and tumour necrosis factor-α levels in Behcet patients with and without ocular involvement</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Türkcü, Fatih Mehmet ; Şahin, Alparslan ; Cingü, Abdullah Kürşat ; Kaya, Savaş ; Yüksel, Hatice ; Cinar, Yasin ; Batmaz, İbrahim</creator><creatorcontrib>Türkcü, Fatih Mehmet ; Şahin, Alparslan ; Cingü, Abdullah Kürşat ; Kaya, Savaş ; Yüksel, Hatice ; Cinar, Yasin ; Batmaz, İbrahim</creatorcontrib><description>Purpose
The objective of this study was to evaluate serum omentin, resistin and tumour necrosis factor-α (TNF-α) levels in Behcet disease (BD) patients with and without ocular involvement, as well as control subjects.
Methods
Omentin, resistin and TNF-α levels were assessed in the plasma of 51 BD patients and compared with those of 24 control subjects.
Results
The plasma resistin and TNF-α levels were significantly higher in the BD patients than in the control group (
p
= 0.028 and
p
= 0.011, respectively), whereas the plasma omentin level was significantly lower in BD patients than in the control group (
p
= 0.035). In the ocular BD, non-ocular BD and control groups, the omentin levels were 8.9 ± 4.65, 8.6 ± 3.61, and 12.4 ± 6.24 ng/mL; resistin levels were 0.29 ± 0.21, 0.24 ± 0.2 and 0.15 ± 0.45 ng/mL; and TNF-α levels were 25.45 ± 3.65, 24.03 ± 2.49 and 21.93 ± 4.86 ng/mL, respectively. Omentin/resistin and TNF-α/omentin ratios were more significant parameters in the demonstration of the differences in the groups; the former was lower and the latter was higher in the patient groups (
p
= 0.001 and
p
= 0.002, respectively).
Conclusions
We demonstrated that the plasma omentin level and omentin/resistin ratio were decreased, whereas the resistin and TNF-α levels and TNF-α/omentin ratio were increased in BD patients. These ratios may be used in the presentation of deviation in the inflammatory and anti-inflammatory balance in BD.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-015-3016-0</identifier><identifier>PMID: 25904298</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Behcet Syndrome - blood ; Behcet Syndrome - diagnosis ; Biomarkers - blood ; Cytokines - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; GPI-Linked Proteins - blood ; Humans ; Inflammatory Disorders ; Lectins - blood ; Male ; Medicine ; Medicine & Public Health ; Ophthalmology ; Resistin - blood ; Tumor Necrosis Factor-alpha - blood ; Uveitis - blood ; Uveitis - diagnosis</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2015-09, Vol.253 (9), p.1565-1568</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-e3103e35068f9c8498d160643b8cbf79d63fe86fa514f1a150dd762be64cdb303</citedby><cites>FETCH-LOGICAL-c414t-e3103e35068f9c8498d160643b8cbf79d63fe86fa514f1a150dd762be64cdb303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-015-3016-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-015-3016-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25904298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Türkcü, Fatih Mehmet</creatorcontrib><creatorcontrib>Şahin, Alparslan</creatorcontrib><creatorcontrib>Cingü, Abdullah Kürşat</creatorcontrib><creatorcontrib>Kaya, Savaş</creatorcontrib><creatorcontrib>Yüksel, Hatice</creatorcontrib><creatorcontrib>Cinar, Yasin</creatorcontrib><creatorcontrib>Batmaz, İbrahim</creatorcontrib><title>Serum omentin, resistin and tumour necrosis factor-α levels in Behcet patients with and without ocular involvement</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
The objective of this study was to evaluate serum omentin, resistin and tumour necrosis factor-α (TNF-α) levels in Behcet disease (BD) patients with and without ocular involvement, as well as control subjects.
Methods
Omentin, resistin and TNF-α levels were assessed in the plasma of 51 BD patients and compared with those of 24 control subjects.
Results
The plasma resistin and TNF-α levels were significantly higher in the BD patients than in the control group (
p
= 0.028 and
p
= 0.011, respectively), whereas the plasma omentin level was significantly lower in BD patients than in the control group (
p
= 0.035). In the ocular BD, non-ocular BD and control groups, the omentin levels were 8.9 ± 4.65, 8.6 ± 3.61, and 12.4 ± 6.24 ng/mL; resistin levels were 0.29 ± 0.21, 0.24 ± 0.2 and 0.15 ± 0.45 ng/mL; and TNF-α levels were 25.45 ± 3.65, 24.03 ± 2.49 and 21.93 ± 4.86 ng/mL, respectively. Omentin/resistin and TNF-α/omentin ratios were more significant parameters in the demonstration of the differences in the groups; the former was lower and the latter was higher in the patient groups (
p
= 0.001 and
p
= 0.002, respectively).
Conclusions
We demonstrated that the plasma omentin level and omentin/resistin ratio were decreased, whereas the resistin and TNF-α levels and TNF-α/omentin ratio were increased in BD patients. These ratios may be used in the presentation of deviation in the inflammatory and anti-inflammatory balance in BD.</description><subject>Adult</subject><subject>Behcet Syndrome - blood</subject><subject>Behcet Syndrome - diagnosis</subject><subject>Biomarkers - blood</subject><subject>Cytokines - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>GPI-Linked Proteins - blood</subject><subject>Humans</subject><subject>Inflammatory Disorders</subject><subject>Lectins - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Resistin - blood</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Uveitis - blood</subject><subject>Uveitis - diagnosis</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1TAQRi0EopfCA7BBXrLAdCa242QJVfmRKrEApO4sx5nQVEl8sZ2L-li8SJ8Jh1tYdjWj8ZnPmsPYS4S3CGDOEoBCIwC1kIC1gEdsh0pqYaC6esx2YCoUjayuTtizlG6g4FLjU3ZS6RZU1TY7lr5SXGceZlryuLzhkdKYSsfd0vO8zmGNfCEfQxnzwfkcorj7zSc60JR44d7TtafM9y6PJSLxX2O-_ru8NWHNPPh1crGghzAdaPvnOXsyuCnRi_t6yr5_uPh2_klcfvn4-fzdpfAKVRYkESRJDXUztL5RbdNjDbWSXeO7wbR9LQdq6sFpVAM61ND3pq46qpXvOwnylL0-5u5j-LlSynYek6dpcguFNVk0YLQu-aageES3S1Okwe7jOLt4axHs5toeXdvi2m6u7Rb_6j5-7Wbq_2_8k1uA6gik8rT8oGhvis6lnPxA6h8OAow6</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Türkcü, Fatih Mehmet</creator><creator>Şahin, Alparslan</creator><creator>Cingü, Abdullah Kürşat</creator><creator>Kaya, Savaş</creator><creator>Yüksel, Hatice</creator><creator>Cinar, Yasin</creator><creator>Batmaz, İbrahim</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150901</creationdate><title>Serum omentin, resistin and tumour necrosis factor-α levels in Behcet patients with and without ocular involvement</title><author>Türkcü, Fatih Mehmet ; Şahin, Alparslan ; Cingü, Abdullah Kürşat ; Kaya, Savaş ; Yüksel, Hatice ; Cinar, Yasin ; Batmaz, İbrahim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-e3103e35068f9c8498d160643b8cbf79d63fe86fa514f1a150dd762be64cdb303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Behcet Syndrome - blood</topic><topic>Behcet Syndrome - diagnosis</topic><topic>Biomarkers - blood</topic><topic>Cytokines - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>GPI-Linked Proteins - blood</topic><topic>Humans</topic><topic>Inflammatory Disorders</topic><topic>Lectins - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Resistin - blood</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Uveitis - blood</topic><topic>Uveitis - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Türkcü, Fatih Mehmet</creatorcontrib><creatorcontrib>Şahin, Alparslan</creatorcontrib><creatorcontrib>Cingü, Abdullah Kürşat</creatorcontrib><creatorcontrib>Kaya, Savaş</creatorcontrib><creatorcontrib>Yüksel, Hatice</creatorcontrib><creatorcontrib>Cinar, Yasin</creatorcontrib><creatorcontrib>Batmaz, İbrahim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Türkcü, Fatih Mehmet</au><au>Şahin, Alparslan</au><au>Cingü, Abdullah Kürşat</au><au>Kaya, Savaş</au><au>Yüksel, Hatice</au><au>Cinar, Yasin</au><au>Batmaz, İbrahim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum omentin, resistin and tumour necrosis factor-α levels in Behcet patients with and without ocular involvement</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>253</volume><issue>9</issue><spage>1565</spage><epage>1568</epage><pages>1565-1568</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
The objective of this study was to evaluate serum omentin, resistin and tumour necrosis factor-α (TNF-α) levels in Behcet disease (BD) patients with and without ocular involvement, as well as control subjects.
Methods
Omentin, resistin and TNF-α levels were assessed in the plasma of 51 BD patients and compared with those of 24 control subjects.
Results
The plasma resistin and TNF-α levels were significantly higher in the BD patients than in the control group (
p
= 0.028 and
p
= 0.011, respectively), whereas the plasma omentin level was significantly lower in BD patients than in the control group (
p
= 0.035). In the ocular BD, non-ocular BD and control groups, the omentin levels were 8.9 ± 4.65, 8.6 ± 3.61, and 12.4 ± 6.24 ng/mL; resistin levels were 0.29 ± 0.21, 0.24 ± 0.2 and 0.15 ± 0.45 ng/mL; and TNF-α levels were 25.45 ± 3.65, 24.03 ± 2.49 and 21.93 ± 4.86 ng/mL, respectively. Omentin/resistin and TNF-α/omentin ratios were more significant parameters in the demonstration of the differences in the groups; the former was lower and the latter was higher in the patient groups (
p
= 0.001 and
p
= 0.002, respectively).
Conclusions
We demonstrated that the plasma omentin level and omentin/resistin ratio were decreased, whereas the resistin and TNF-α levels and TNF-α/omentin ratio were increased in BD patients. These ratios may be used in the presentation of deviation in the inflammatory and anti-inflammatory balance in BD.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25904298</pmid><doi>10.1007/s00417-015-3016-0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2015-09, Vol.253 (9), p.1565-1568 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1707555067 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Behcet Syndrome - blood Behcet Syndrome - diagnosis Biomarkers - blood Cytokines - blood Enzyme-Linked Immunosorbent Assay Female GPI-Linked Proteins - blood Humans Inflammatory Disorders Lectins - blood Male Medicine Medicine & Public Health Ophthalmology Resistin - blood Tumor Necrosis Factor-alpha - blood Uveitis - blood Uveitis - diagnosis |
| title | Serum omentin, resistin and tumour necrosis factor-α levels in Behcet patients with and without ocular involvement |
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