Adaptive mutation PB2 D701N promotes nuclear import of influenza vRNPs in mammalian cells

The segmented genome of influenza viruses is translocated into the nucleus to initiate transcription and replication. The gene segments are present as viral ribonucleoprotein (vRNP) particles composed of RNA, multiple copies of the nucleoprotein (NP), and the polymerase subunits PB1, PB2 and PA. The...

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Veröffentlicht in:	European journal of cell biology 2015-07, Vol.94 (7-9), p.368-374
Hauptverfasser:	Sediri, Hanna, Schwalm, Folker, Gabriel, Gülsah, Klenk, Hans-Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - genetics Active Transport, Cell Nucleus - physiology Cell Line, Tumor Cell Nucleus - metabolism HEK293 Cells Humans Influenza A Virus, H7N7 Subtype - genetics Influenza A Virus, H9N2 Subtype - genetics Influenza virus Mutation - genetics Nuclear import Nuclear Localization Signals - genetics PB2 Protein Transport - genetics Protein Transport - physiology Ribonucleoproteins - metabolism RNA Replicase - genetics RNA, Viral - genetics Viral Proteins - genetics Virus Replication - genetics
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