Anti Proliferative and Pro Apoptotic Effects of Flavonoid Quercetin Are Mediated by CB1 Receptor in Human Colon Cancer Cell Lines

Quercetin, the major constituent of flavonoid and widely present in fruits and vegetables, is an attractive compound for cancer prevention due to its beneficial anti proliferative effects, showing a crucial role in the regulation of apoptosis and cell cycle signaling. In vitro studies have demonstra...

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Veröffentlicht in:	Journal of cellular physiology 2015-12, Vol.230 (12), p.2973-2980
Hauptverfasser:	Refolo, Maria Grazia, D'Alessandro, Rosalba, Malerba, Natascia, Laezza, Chiara, Bifulco, Maurizio, Messa, Caterina, Caruso, Maria Gabriella, Notarnicola, Maria, Tutino, Valeria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Caco-2 Cells Cannabinoid Receptor Agonists - pharmacology Cell Movement - drug effects Cell Proliferation - drug effects Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Estrogens Humans Quercetin - pharmacology Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - metabolism Signal Transduction - drug effects Up-Regulation
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