Ortho-substituted polychlorinated biphenyls alter calcium regulation by a ryanodine receptor-mediated mechanism: structural specificity toward skeletal- and cardiac-type microsomal calcium release channels

We investigated a novel molecular mechanism by which polychlorinated biphenyls (PCBs) alter microsomal Ca2+ transport with sarcoplasmic reticulum (SR) membranes isolated from skeletal and cardiac muscles. Aroclors with an intermediate weight percent of chlorine enhance by >6-fold the binding of 1...

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Veröffentlicht in:	Molecular pharmacology 1996-04, Vol.49 (4), p.740-751
Hauptverfasser:	Wong, P W, Pessah, I N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aroclors - pharmacology Calcium - metabolism Calcium Channels - drug effects Calcium Channels - physiology Male Muscle Proteins - drug effects Muscle Proteins - physiology Muscle, Skeletal - metabolism Myocardium - metabolism Polychlorinated Biphenyls - pharmacology Rabbits Ryanodine - metabolism Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum - metabolism Structure-Activity Relationship
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