Detection of germ cell mutagenicity of trophosphamide by the spermatid micronucleus test in the rat

The effects of the antineoplastic drug trophosphamide (TP) on male rat germ cells were examined with the spermatid micronucleus test (SMNT). We used the microdissection technique in order to isolate stage I of the seminiferous epithelial cycle, where the cells that have just passed the meiotic divis...

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