Chemical studies of phytoestrogens and related compounds in dietary supplements: flax and chaparral
High-performance liquid chromatographic (HPLC) and mass spectrometric (MS) procedures were developed 10 determine lignans in flaxseed (Linum usitatissimum) and chaparral (Larrea tridentata). Flaxseed contains high levels of phytoestrogens. Chaparral has been associated with acute nonviral toxic hepa...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1995, Vol.208 (1), p.6-12 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
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| creator | Obermeyer, W. R. Musser, S. M. Betz, J. M. Casey, R. E. Pohland, A. E. Page, S. W. |
| description | High-performance liquid chromatographic (HPLC) and mass spectrometric (MS) procedures were developed 10 determine lignans in flaxseed (Linum usitatissimum) and chaparral (Larrea tridentata). Flaxseed contains high levels of phytoestrogens. Chaparral has been associated with acute nonviral toxic hepatitis and contains lignans that are structurally similar to known estrogenic compounds. Both flaxseed and chaparral products have been marketed as dietary supplements. A mild enzyme hydrolysis procedure to prevent the formation of artifacts in the isolation step was used in the determination of secoisolariciresinol in flaxseed products. HPLC with ultraviolet spectral (UV) or MS detection was used as the determinative steps. HPLC procedures with UV detection and mass spectrometry were developed to characterize the phenolic components, including lignans and flavonoids, of chaparral and to direct fractionation studies for the bioassays. |
| doi_str_mv | 10.3181/00379727-208-43824 |
| format | Article |
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R. ; Musser, S. M. ; Betz, J. M. ; Casey, R. E. ; Pohland, A. E. ; Page, S. W.</creator><creatorcontrib>Obermeyer, W. R. ; Musser, S. M. ; Betz, J. M. ; Casey, R. E. ; Pohland, A. E. ; Page, S. W. ; Food and Drug Administration, Washington, DC ; Sociedade de Ciencias Agrarias de Portugal, Lisbon (Portugal)</creatorcontrib><description>High-performance liquid chromatographic (HPLC) and mass spectrometric (MS) procedures were developed 10 determine lignans in flaxseed (Linum usitatissimum) and chaparral (Larrea tridentata). Flaxseed contains high levels of phytoestrogens. Chaparral has been associated with acute nonviral toxic hepatitis and contains lignans that are structurally similar to known estrogenic compounds. Both flaxseed and chaparral products have been marketed as dietary supplements. A mild enzyme hydrolysis procedure to prevent the formation of artifacts in the isolation step was used in the determination of secoisolariciresinol in flaxseed products. HPLC with ultraviolet spectral (UV) or MS detection was used as the determinative steps. HPLC procedures with UV detection and mass spectrometry were developed to characterize the phenolic components, including lignans and flavonoids, of chaparral and to direct fractionation studies for the bioassays.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1525-1373</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-208-43824</identifier><identifier>PMID: 7892296</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>antioxidantes ; antioxidants ; antioxydant ; Butylene Glycols - analysis ; chemical composition ; chromatographie liquide haute press ; Chromatography, High Pressure Liquid - methods ; complement alimentaire ; compose phenolique ; composicion quimica ; composition chimique ; compuestos fenolicos ; cromatografia liquida alta presion ; drugs ; estrogenos ; Estrogens, Non-Steroidal - analysis ; flavonoide ; flavonoides ; flavonoids ; flax ; Food, Fortified - analysis ; high pressure liquid chromatography ; Isoflavones ; Larrea tridentata ; Lignans - analysis ; Lignin - analysis ; ligninas ; lignine ; lignins ; lin ; lino ; Linum usitatissimum ; Mass Spectrometry ; medicament ; medicamentos ; oestrogene ; oestrogens ; phenolic compounds ; Phytoestrogens ; Plant Preparations ; Plants - chemistry ; substance toxique ; suplementos ; supplements ; sustancias toxicas ; toxic substances ; zygophyllaceae</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1995, Vol.208 (1), p.6-12</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-9c0e6ceba5cc2ec4ff5f4ccb1b9e3a478843351ed29b2fd28239c191515e79b13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7892296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obermeyer, W. R.</creatorcontrib><creatorcontrib>Musser, S. M.</creatorcontrib><creatorcontrib>Betz, J. M.</creatorcontrib><creatorcontrib>Casey, R. E.</creatorcontrib><creatorcontrib>Pohland, A. E.</creatorcontrib><creatorcontrib>Page, S. W.</creatorcontrib><creatorcontrib>Food and Drug Administration, Washington, DC</creatorcontrib><creatorcontrib>Sociedade de Ciencias Agrarias de Portugal, Lisbon (Portugal)</creatorcontrib><title>Chemical studies of phytoestrogens and related compounds in dietary supplements: flax and chaparral</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>High-performance liquid chromatographic (HPLC) and mass spectrometric (MS) procedures were developed 10 determine lignans in flaxseed (Linum usitatissimum) and chaparral (Larrea tridentata). Flaxseed contains high levels of phytoestrogens. Chaparral has been associated with acute nonviral toxic hepatitis and contains lignans that are structurally similar to known estrogenic compounds. Both flaxseed and chaparral products have been marketed as dietary supplements. A mild enzyme hydrolysis procedure to prevent the formation of artifacts in the isolation step was used in the determination of secoisolariciresinol in flaxseed products. HPLC with ultraviolet spectral (UV) or MS detection was used as the determinative steps. HPLC procedures with UV detection and mass spectrometry were developed to characterize the phenolic components, including lignans and flavonoids, of chaparral and to direct fractionation studies for the bioassays.</description><subject>antioxidantes</subject><subject>antioxidants</subject><subject>antioxydant</subject><subject>Butylene Glycols - analysis</subject><subject>chemical composition</subject><subject>chromatographie liquide haute press</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>complement alimentaire</subject><subject>compose phenolique</subject><subject>composicion quimica</subject><subject>composition chimique</subject><subject>compuestos fenolicos</subject><subject>cromatografia liquida alta presion</subject><subject>drugs</subject><subject>estrogenos</subject><subject>Estrogens, Non-Steroidal - analysis</subject><subject>flavonoide</subject><subject>flavonoides</subject><subject>flavonoids</subject><subject>flax</subject><subject>Food, Fortified - analysis</subject><subject>high pressure liquid chromatography</subject><subject>Isoflavones</subject><subject>Larrea tridentata</subject><subject>Lignans - analysis</subject><subject>Lignin - analysis</subject><subject>ligninas</subject><subject>lignine</subject><subject>lignins</subject><subject>lin</subject><subject>lino</subject><subject>Linum usitatissimum</subject><subject>Mass Spectrometry</subject><subject>medicament</subject><subject>medicamentos</subject><subject>oestrogene</subject><subject>oestrogens</subject><subject>phenolic compounds</subject><subject>Phytoestrogens</subject><subject>Plant Preparations</subject><subject>Plants - chemistry</subject><subject>substance toxique</subject><subject>suplementos</subject><subject>supplements</subject><subject>sustancias toxicas</subject><subject>toxic substances</subject><subject>zygophyllaceae</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1525-1373</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EKqXwA0ggr9iF-pHEMTtU8ZIqsYCuLccZt6mSONiJRP-etCksWc1izr2aOQhdU3LPaUbnhHAhBRMRI1kU84zFJ2hKE5ZElAt-iqZ7INoT5-gihC0hJCWMTNBEZJIxmU6RWWygLo2ucOj6ooSAncXtZtc5CJ13a2gC1k2BPVS6gwIbV7eub4qAywYPfKf9Doe-bSuooenCA7aV_j5EzEa32ntdXaIzq6sAV8c5Q6vnp8_Fa7R8f3lbPC4jwyXrImkIpAZynRjDwMTWJjY2Jqe5BK5jkWUx5wmFgsmc2YJljEtDJU1oAkLmlM_Q3djbevfVD_erugwGqko34PqgqCCC8iQbQDaCxrsQPFjV-rIePlGUqL1Z9WtWDWbVwewQujm293kNxV_kqHLYz8d90GtQW9f7Znj2_8bbMWG1U3rty6BWH1TKlBDKSMr5D0G4jEo</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Obermeyer, W. R.</creator><creator>Musser, S. M.</creator><creator>Betz, J. M.</creator><creator>Casey, R. E.</creator><creator>Pohland, A. E.</creator><creator>Page, S. W.</creator><general>SAGE Publications</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>1995</creationdate><title>Chemical studies of phytoestrogens and related compounds in dietary supplements: flax and chaparral</title><author>Obermeyer, W. R. ; Musser, S. M. ; Betz, J. M. ; Casey, R. E. ; Pohland, A. E. ; Page, S. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-9c0e6ceba5cc2ec4ff5f4ccb1b9e3a478843351ed29b2fd28239c191515e79b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>antioxidantes</topic><topic>antioxidants</topic><topic>antioxydant</topic><topic>Butylene Glycols - analysis</topic><topic>chemical composition</topic><topic>chromatographie liquide haute press</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>complement alimentaire</topic><topic>compose phenolique</topic><topic>composicion quimica</topic><topic>composition chimique</topic><topic>compuestos fenolicos</topic><topic>cromatografia liquida alta presion</topic><topic>drugs</topic><topic>estrogenos</topic><topic>Estrogens, Non-Steroidal - analysis</topic><topic>flavonoide</topic><topic>flavonoides</topic><topic>flavonoids</topic><topic>flax</topic><topic>Food, Fortified - analysis</topic><topic>high pressure liquid chromatography</topic><topic>Isoflavones</topic><topic>Larrea tridentata</topic><topic>Lignans - analysis</topic><topic>Lignin - analysis</topic><topic>ligninas</topic><topic>lignine</topic><topic>lignins</topic><topic>lin</topic><topic>lino</topic><topic>Linum usitatissimum</topic><topic>Mass Spectrometry</topic><topic>medicament</topic><topic>medicamentos</topic><topic>oestrogene</topic><topic>oestrogens</topic><topic>phenolic compounds</topic><topic>Phytoestrogens</topic><topic>Plant Preparations</topic><topic>Plants - chemistry</topic><topic>substance toxique</topic><topic>suplementos</topic><topic>supplements</topic><topic>sustancias toxicas</topic><topic>toxic substances</topic><topic>zygophyllaceae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obermeyer, W. R.</creatorcontrib><creatorcontrib>Musser, S. M.</creatorcontrib><creatorcontrib>Betz, J. M.</creatorcontrib><creatorcontrib>Casey, R. E.</creatorcontrib><creatorcontrib>Pohland, A. E.</creatorcontrib><creatorcontrib>Page, S. W.</creatorcontrib><creatorcontrib>Food and Drug Administration, Washington, DC</creatorcontrib><creatorcontrib>Sociedade de Ciencias Agrarias de Portugal, Lisbon (Portugal)</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obermeyer, W. R.</au><au>Musser, S. M.</au><au>Betz, J. M.</au><au>Casey, R. E.</au><au>Pohland, A. E.</au><au>Page, S. W.</au><aucorp>Food and Drug Administration, Washington, DC</aucorp><aucorp>Sociedade de Ciencias Agrarias de Portugal, Lisbon (Portugal)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical studies of phytoestrogens and related compounds in dietary supplements: flax and chaparral</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1995</date><risdate>1995</risdate><volume>208</volume><issue>1</issue><spage>6</spage><epage>12</epage><pages>6-12</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1525-1373</eissn><eissn>1535-3699</eissn><abstract>High-performance liquid chromatographic (HPLC) and mass spectrometric (MS) procedures were developed 10 determine lignans in flaxseed (Linum usitatissimum) and chaparral (Larrea tridentata). Flaxseed contains high levels of phytoestrogens. Chaparral has been associated with acute nonviral toxic hepatitis and contains lignans that are structurally similar to known estrogenic compounds. Both flaxseed and chaparral products have been marketed as dietary supplements. A mild enzyme hydrolysis procedure to prevent the formation of artifacts in the isolation step was used in the determination of secoisolariciresinol in flaxseed products. HPLC with ultraviolet spectral (UV) or MS detection was used as the determinative steps. HPLC procedures with UV detection and mass spectrometry were developed to characterize the phenolic components, including lignans and flavonoids, of chaparral and to direct fractionation studies for the bioassays.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>7892296</pmid><doi>10.3181/00379727-208-43824</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1995, Vol.208 (1), p.6-12 |
| issn | 0037-9727 1535-3702 1525-1373 1535-3699 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | antioxidantes antioxidants antioxydant Butylene Glycols - analysis chemical composition chromatographie liquide haute press Chromatography, High Pressure Liquid - methods complement alimentaire compose phenolique composicion quimica composition chimique compuestos fenolicos cromatografia liquida alta presion drugs estrogenos Estrogens, Non-Steroidal - analysis flavonoide flavonoides flavonoids flax Food, Fortified - analysis high pressure liquid chromatography Isoflavones Larrea tridentata Lignans - analysis Lignin - analysis ligninas lignine lignins lin lino Linum usitatissimum Mass Spectrometry medicament medicamentos oestrogene oestrogens phenolic compounds Phytoestrogens Plant Preparations Plants - chemistry substance toxique suplementos supplements sustancias toxicas toxic substances zygophyllaceae |
| title | Chemical studies of phytoestrogens and related compounds in dietary supplements: flax and chaparral |
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