Prevention of SIV Infection in Macaques by (R)-9-(2-Phosphonylmethoxypropyl)adenine

The efficacy of pre- and postexposure treatment with the antiviral compound (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) was tested against simian immunodeficiency virus (SIV) in macaques as a model for human immunodeficiency virus (HIV). PMPA was administered subcutaneously once daily beginning...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1995-11, Vol.270 (5239), p.1197-1199
Hauptverfasser:	Tsai, Che-Chung, Follis, Kathryn E., Sabo, Alexander, Beck, Thomas W., Grant, Richard F., Bischofberger, Norbert, Benveniste, Raoul E., Black, Roberta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - administration & dosage Adenine - analogs & derivatives Adenine - pharmacology AIDS Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies Antibodies, Viral - blood Antiviral agents Antiviral Agents - administration & dosage Antiviral Agents - therapeutic use Antivirals Base Sequence Biological and medical sciences Blood Blood plasma Cells, Cultured Dosage HIV HIV Infections - drug therapy HIV Infections - prevention & control Humans Infections Injections, Subcutaneous Inoculation Leukocytes, Mononuclear - virology Lymph Nodes - virology Macaca fascicularis Medical sciences Molecular Sequence Data Organophosphonates Organophosphorus Compounds - administration & dosage Organophosphorus Compounds - pharmacology Pharmacology. Drug treatments Simian Acquired Immunodeficiency Syndrome - drug therapy Simian Acquired Immunodeficiency Syndrome - prevention & control simian immunodeficiency virus Simian Immunodeficiency Virus - drug effects Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - isolation & purification Tenofovir Viruses
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