Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo

Hypoxia is an important factor in radioresistance of laryngeal carcinoma. Glucose transporter-1 (GLUT-1) is an important hypoxic marker in malignant tumors, including laryngeal carcinoma. Apigenin is a natural phytoestrogen flavonoid that has potential anticancer effects. Various studies have report...

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Veröffentlicht in:	Oncology reports 2015-10, Vol.34 (4), p.1805-1814
Hauptverfasser:	BAO, YANG-YANG, ZHOU, SHUI-HONG, LU, ZHONG-JIE, FAN, JUN, HUANG, YA-PING
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apigenin Apigenin - administration & dosage Apoptosis Apoptosis - drug effects Bioflavonoids Cancer therapies Carcinoma - drug therapy Carcinoma - genetics Carcinoma - radiotherapy Cell Hypoxia - drug effects Cell Hypoxia - genetics Cell Line, Tumor Cell Proliferation - drug effects Cellular signal transduction Experiments Flavones Flavonoids Gene Expression Regulation, Neoplastic - drug effects Glucose Transporter Type 1 - antagonists & inhibitors Glucose Transporter Type 1 - biosynthesis Glucose Transporter Type 1 - genetics GLUT-1 Humans Hypoxia Laboratory animals Laryngeal cancer laryngeal carcinoma Laryngeal Neoplasms - drug therapy Laryngeal Neoplasms - genetics Laryngeal Neoplasms - radiotherapy Medical research Mice Phosphatidylinositol 3-Kinases - genetics PI3K/Akt signaling Proteins Radiation therapy Radiation Tolerance - drug effects Radiation Tolerance - genetics radiosensitivity RNA, Messenger Signal transduction Standard deviation Studies Tumors X-Rays xenograft Xenograft Model Antitumor Assays
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