B-type natriuretic peptide response and reverse left ventricular remodeling after surgical correction of functional mitral regurgitation in patients with advanced cardiomyopathy

Abstract Background Restrictive mitral annuloplasty (RMA) can reverse left ventricular (LV) remodeling and reduce plasma B-type natriuretic peptide (BNP), a surrogate biomarker of heart failure. However, the relationship between reverse LV remodeling and plasma BNP changes after RMA is poorly define...

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Veröffentlicht in:	Journal of cardiology 2015-10, Vol.66 (4), p.279-285
Hauptverfasser:	Kainuma, Satoshi, MD, Taniguchi, Kazuhiro, MD, PhD, Toda, Koichi, MD, PhD, Shudo, Yasuhiro, MD, PhD, Takeda, Koji, MD, PhD, Funatsu, Toshihiro, MD, PhD, Miyagawa, Shigeru, MD, PhD, Kondoh, Haruhiko, MD, PhD, Nishi, Hiroyuki, MD, Yoshikawa, Yasushi, MD, Fukushima, Satsuki, MD, PhD, Hamada, Seiki, MD, PhD, Kubo, Koji, RT, Daimon, Takashi, PhD, Sawa, Yoshiki, MD, PhD, FJCC
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced cardiomyopathy Aged Cardiomyopathies - complications Cardiovascular Female Functional mitral regurgitation Heart Failure - blood Heart Ventricles - physiopathology Humans Male Middle Aged Mitral Valve Annuloplasty Mitral Valve Insufficiency - etiology Mitral Valve Insufficiency - physiopathology Mitral Valve Insufficiency - surgery Multidetector Computed Tomography Natriuretic Peptide, Brain - blood Plasma B-type natriuretic peptide Restrictive mitral annuloplasty Stroke Volume - physiology Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - physiopathology Ventricular Remodeling - physiology Wall stress
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Zusammenfassung:	Abstract Background Restrictive mitral annuloplasty (RMA) can reverse left ventricular (LV) remodeling and reduce plasma B-type natriuretic peptide (BNP), a surrogate biomarker of heart failure. However, the relationship between reverse LV remodeling and plasma BNP changes after RMA is poorly defined. We explored the main hemodynamic factors contributing to change in plasma BNP after RMA in patients with functional mitral regurgitation (MR). Methods Twenty-four patients with moderate to severe functional MR secondary to LV systolic dysfunction [ejection fraction (EF)
ISSN:	0914-5087 1876-4738
DOI:	10.1016/j.jjcc.2015.02.015