The molecular pathway of ATP-sensitive potassium channel in endothelial cells for mediating arteriole relaxation

The endothelial molecular pathway of a new ATP-sensitive potassium channel (KATP) opener natakalim was investigated in mesenteric arterioles of rats. A DMT wire myograph was used to evaluate the vasorelaxation effects of natakalim. Ca2+ responses of endothelial cells induced by natakalim were measur...

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Veröffentlicht in:	Life sciences (1973) 2015-09, Vol.137, p.164-169
Hauptverfasser:	Chen, Xuejun, Han, Wenzhi, Zhang, Yanfang, Cui, Wenyu, Pan, Zhiyuan, Jin, Xin, Long, Chaoliang, Wang, Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Allyl Compounds - antagonists & inhibitors Allyl Compounds - pharmacology Anilides - pharmacology Animals Arterioles - drug effects Arterioles - metabolism Calcium - metabolism Capsaicin - analogs & derivatives Capsaicin - pharmacology Cells, Cultured Cinnamates - pharmacology Down-Regulation - drug effects Endothelial Cells - drug effects Endothelial Cells - metabolism Intracellular calcium concentration KATP Channels - antagonists & inhibitors KATP Channels - metabolism Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism Natakalim Nitric oxide Nitric Oxide - metabolism Propylamines - antagonists & inhibitors Propylamines - pharmacology Rats RNA, Small Interfering - pharmacology Transient receptor potential vanilloid 1 TRPV Cation Channels - metabolism Vasodilation - drug effects Vasodilation - physiology
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