Effect of plasmid backbone modification by different human CpG motifs on the immunogenicity of DNA vaccine vectors

DNA vaccines, in general, have been found to be poorly immunogenic in nonhuman primates and humans as compared with mie. As the immunogenicity of DNA plasmids relies, to a large extent, on the presence of CpG motifs as built in adjuvants, we addressed the issue of poor immunogenicity by inserting re...

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