Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer

Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose...

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Veröffentlicht in:	Journal of controlled release 2015-09, Vol.214, p.76-84
Hauptverfasser:	Rosenberger, I., Strauss, A., Dobiasch, S., Weis, C., Szanyi, S., Gil-Iceta, L., Alonso, E., González Esparza, M., Gómez-Vallejo, V., Szczupak, B., Plaza-García, S., Mirzaei, S., Israel, L.L., Bianchessi, S., Scanziani, E., Lellouche, J.-P., Knoll, P., Werner, J., Felix, K., Grenacher, L., Reese, T., Kreuter, J., Jiménez-González, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Ferric Compounds - chemistry Galectin 1 - chemistry Galectin 1 - metabolism Handheld gamma camera Humans Maghemite Magnetic Resonance Imaging Magnetic resonance imaging (MRI) Magnetics Magnetite Nanoparticles Mice Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Radionuclide Imaging Radiopharmaceuticals Recombinant Proteins - chemistry rHSA nanoparticles Serum Albumin - chemistry Single photon emission computed tomography–computer tomography (SPECT–CT) t-PA-ligands to galectins t-PApeptide1LAC Tissue Plasminogen Activator - metabolism Tomography, Emission-Computed, Single-Photon Xenograft Model Antitumor Assays
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