Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer
Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose...
Gespeichert in:
| Veröffentlicht in: | Journal of controlled release 2015-09, Vol.214, p.76-84 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 84 |
|---|---|
| container_issue | |
| container_start_page | 76 |
| container_title | Journal of controlled release |
| container_volume | 214 |
| creator | Rosenberger, I. Strauss, A. Dobiasch, S. Weis, C. Szanyi, S. Gil-Iceta, L. Alonso, E. González Esparza, M. Gómez-Vallejo, V. Szczupak, B. Plaza-García, S. Mirzaei, S. Israel, L.L. Bianchessi, S. Scanziani, E. Lellouche, J.-P. Knoll, P. Werner, J. Felix, K. Grenacher, L. Reese, T. Kreuter, J. Jiménez-González, M. |
| description | Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose, magnetic, biodegradable nanoparticles prepared using recombinant human serum albumin (rHSA) and incorporated iron oxide (maghemite, γ-Fe2O3) nanoparticles were developed. Galectin-1 has been chosen as target receptor as this protein is upregulated in pancreatic cancer and its precursor lesions but not in healthy pancreatic tissue nor in pancreatitis. Tissue plasminogen activator derived peptides (t-PA-ligands), that have a high affinity to galectin-1 have been chosen as target moieties and were covalently attached onto the nanoparticle surface. Improved targeting and imaging properties were shown in mice using single photon emission computed tomography–computer tomography (SPECT–CT), a handheld gamma camera, and magnetic resonance imaging (MRI).
[Display omitted] |
| doi_str_mv | 10.1016/j.jconrel.2015.07.017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1706209371</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168365915300304</els_id><sourcerecordid>1706209371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-e53f013795c06e45ef7ff8f4b132768288863a320dedd7d7659744ce78a8ddb63</originalsourceid><addsrcrecordid>eNqFkD1PwzAQhi0EoqXwE0AZWRLsOI6dCaGKL6kSA2W2XPtcOUrjYKdI_HsctbAy3Ts8d6f3Qeia4IJgUt-1Rat9H6ArSkxYgXmBCT9BcyI4zaumYadonjiR05o1M3QRY4sxZrTi52hW1qQpcdPM0ftahS2MYDLj1Lb3cXQ626UEU-hV7wcVUuwgZtaHbAfGadVlLjGu32beZoPqdQA18TpFCJfozKouwtVxLtDH0-N6-ZKv3p5flw-rXFekHHNg1GJCecM0rqFiYLm1wlYbQktei1IIUVNFS2zAGG546sGrSgMXShizqekC3R7uDsF_7iGOcueihq5TPfh9lITjOrWknCSUHVAdfIwBrBxCqhC-JcFy8ilbefQpJ58Sc5l8pr2b44v9JlX_2_oVmID7AwCp6JeDIKN2kCwYF0CP0nj3z4sfgG6J7A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1706209371</pqid></control><display><type>article</type><title>Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Rosenberger, I. ; Strauss, A. ; Dobiasch, S. ; Weis, C. ; Szanyi, S. ; Gil-Iceta, L. ; Alonso, E. ; González Esparza, M. ; Gómez-Vallejo, V. ; Szczupak, B. ; Plaza-García, S. ; Mirzaei, S. ; Israel, L.L. ; Bianchessi, S. ; Scanziani, E. ; Lellouche, J.-P. ; Knoll, P. ; Werner, J. ; Felix, K. ; Grenacher, L. ; Reese, T. ; Kreuter, J. ; Jiménez-González, M.</creator><creatorcontrib>Rosenberger, I. ; Strauss, A. ; Dobiasch, S. ; Weis, C. ; Szanyi, S. ; Gil-Iceta, L. ; Alonso, E. ; González Esparza, M. ; Gómez-Vallejo, V. ; Szczupak, B. ; Plaza-García, S. ; Mirzaei, S. ; Israel, L.L. ; Bianchessi, S. ; Scanziani, E. ; Lellouche, J.-P. ; Knoll, P. ; Werner, J. ; Felix, K. ; Grenacher, L. ; Reese, T. ; Kreuter, J. ; Jiménez-González, M.</creatorcontrib><description>Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose, magnetic, biodegradable nanoparticles prepared using recombinant human serum albumin (rHSA) and incorporated iron oxide (maghemite, γ-Fe2O3) nanoparticles were developed. Galectin-1 has been chosen as target receptor as this protein is upregulated in pancreatic cancer and its precursor lesions but not in healthy pancreatic tissue nor in pancreatitis. Tissue plasminogen activator derived peptides (t-PA-ligands), that have a high affinity to galectin-1 have been chosen as target moieties and were covalently attached onto the nanoparticle surface. Improved targeting and imaging properties were shown in mice using single photon emission computed tomography–computer tomography (SPECT–CT), a handheld gamma camera, and magnetic resonance imaging (MRI).
[Display omitted]</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2015.07.017</identifier><identifier>PMID: 26192099</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Cell Line, Tumor ; Ferric Compounds - chemistry ; Galectin 1 - chemistry ; Galectin 1 - metabolism ; Handheld gamma camera ; Humans ; Maghemite ; Magnetic Resonance Imaging ; Magnetic resonance imaging (MRI) ; Magnetics ; Magnetite Nanoparticles ; Mice ; Pancreatic Neoplasms - diagnosis ; Pancreatic Neoplasms - metabolism ; Pancreatic Neoplasms - pathology ; Radionuclide Imaging ; Radiopharmaceuticals ; Recombinant Proteins - chemistry ; rHSA nanoparticles ; Serum Albumin - chemistry ; Single photon emission computed tomography–computer tomography (SPECT–CT) ; t-PA-ligands to galectins ; t-PApeptide1LAC ; Tissue Plasminogen Activator - metabolism ; Tomography, Emission-Computed, Single-Photon ; Xenograft Model Antitumor Assays</subject><ispartof>Journal of controlled release, 2015-09, Vol.214, p.76-84</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-e53f013795c06e45ef7ff8f4b132768288863a320dedd7d7659744ce78a8ddb63</citedby><cites>FETCH-LOGICAL-c412t-e53f013795c06e45ef7ff8f4b132768288863a320dedd7d7659744ce78a8ddb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168365915300304$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26192099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenberger, I.</creatorcontrib><creatorcontrib>Strauss, A.</creatorcontrib><creatorcontrib>Dobiasch, S.</creatorcontrib><creatorcontrib>Weis, C.</creatorcontrib><creatorcontrib>Szanyi, S.</creatorcontrib><creatorcontrib>Gil-Iceta, L.</creatorcontrib><creatorcontrib>Alonso, E.</creatorcontrib><creatorcontrib>González Esparza, M.</creatorcontrib><creatorcontrib>Gómez-Vallejo, V.</creatorcontrib><creatorcontrib>Szczupak, B.</creatorcontrib><creatorcontrib>Plaza-García, S.</creatorcontrib><creatorcontrib>Mirzaei, S.</creatorcontrib><creatorcontrib>Israel, L.L.</creatorcontrib><creatorcontrib>Bianchessi, S.</creatorcontrib><creatorcontrib>Scanziani, E.</creatorcontrib><creatorcontrib>Lellouche, J.-P.</creatorcontrib><creatorcontrib>Knoll, P.</creatorcontrib><creatorcontrib>Werner, J.</creatorcontrib><creatorcontrib>Felix, K.</creatorcontrib><creatorcontrib>Grenacher, L.</creatorcontrib><creatorcontrib>Reese, T.</creatorcontrib><creatorcontrib>Kreuter, J.</creatorcontrib><creatorcontrib>Jiménez-González, M.</creatorcontrib><title>Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose, magnetic, biodegradable nanoparticles prepared using recombinant human serum albumin (rHSA) and incorporated iron oxide (maghemite, γ-Fe2O3) nanoparticles were developed. Galectin-1 has been chosen as target receptor as this protein is upregulated in pancreatic cancer and its precursor lesions but not in healthy pancreatic tissue nor in pancreatitis. Tissue plasminogen activator derived peptides (t-PA-ligands), that have a high affinity to galectin-1 have been chosen as target moieties and were covalently attached onto the nanoparticle surface. Improved targeting and imaging properties were shown in mice using single photon emission computed tomography–computer tomography (SPECT–CT), a handheld gamma camera, and magnetic resonance imaging (MRI).
[Display omitted]</description><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Ferric Compounds - chemistry</subject><subject>Galectin 1 - chemistry</subject><subject>Galectin 1 - metabolism</subject><subject>Handheld gamma camera</subject><subject>Humans</subject><subject>Maghemite</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic resonance imaging (MRI)</subject><subject>Magnetics</subject><subject>Magnetite Nanoparticles</subject><subject>Mice</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Recombinant Proteins - chemistry</subject><subject>rHSA nanoparticles</subject><subject>Serum Albumin - chemistry</subject><subject>Single photon emission computed tomography–computer tomography (SPECT–CT)</subject><subject>t-PA-ligands to galectins</subject><subject>t-PApeptide1LAC</subject><subject>Tissue Plasminogen Activator - metabolism</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqXwE0AZWRLsOI6dCaGKL6kSA2W2XPtcOUrjYKdI_HsctbAy3Ts8d6f3Qeia4IJgUt-1Rat9H6ArSkxYgXmBCT9BcyI4zaumYadonjiR05o1M3QRY4sxZrTi52hW1qQpcdPM0ftahS2MYDLj1Lb3cXQ626UEU-hV7wcVUuwgZtaHbAfGadVlLjGu32beZoPqdQA18TpFCJfozKouwtVxLtDH0-N6-ZKv3p5flw-rXFekHHNg1GJCecM0rqFiYLm1wlYbQktei1IIUVNFS2zAGG546sGrSgMXShizqekC3R7uDsF_7iGOcueihq5TPfh9lITjOrWknCSUHVAdfIwBrBxCqhC-JcFy8ilbefQpJ58Sc5l8pr2b44v9JlX_2_oVmID7AwCp6JeDIKN2kCwYF0CP0nj3z4sfgG6J7A</recordid><startdate>20150928</startdate><enddate>20150928</enddate><creator>Rosenberger, I.</creator><creator>Strauss, A.</creator><creator>Dobiasch, S.</creator><creator>Weis, C.</creator><creator>Szanyi, S.</creator><creator>Gil-Iceta, L.</creator><creator>Alonso, E.</creator><creator>González Esparza, M.</creator><creator>Gómez-Vallejo, V.</creator><creator>Szczupak, B.</creator><creator>Plaza-García, S.</creator><creator>Mirzaei, S.</creator><creator>Israel, L.L.</creator><creator>Bianchessi, S.</creator><creator>Scanziani, E.</creator><creator>Lellouche, J.-P.</creator><creator>Knoll, P.</creator><creator>Werner, J.</creator><creator>Felix, K.</creator><creator>Grenacher, L.</creator><creator>Reese, T.</creator><creator>Kreuter, J.</creator><creator>Jiménez-González, M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150928</creationdate><title>Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer</title><author>Rosenberger, I. ; Strauss, A. ; Dobiasch, S. ; Weis, C. ; Szanyi, S. ; Gil-Iceta, L. ; Alonso, E. ; González Esparza, M. ; Gómez-Vallejo, V. ; Szczupak, B. ; Plaza-García, S. ; Mirzaei, S. ; Israel, L.L. ; Bianchessi, S. ; Scanziani, E. ; Lellouche, J.-P. ; Knoll, P. ; Werner, J. ; Felix, K. ; Grenacher, L. ; Reese, T. ; Kreuter, J. ; Jiménez-González, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-e53f013795c06e45ef7ff8f4b132768288863a320dedd7d7659744ce78a8ddb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Ferric Compounds - chemistry</topic><topic>Galectin 1 - chemistry</topic><topic>Galectin 1 - metabolism</topic><topic>Handheld gamma camera</topic><topic>Humans</topic><topic>Maghemite</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic resonance imaging (MRI)</topic><topic>Magnetics</topic><topic>Magnetite Nanoparticles</topic><topic>Mice</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Recombinant Proteins - chemistry</topic><topic>rHSA nanoparticles</topic><topic>Serum Albumin - chemistry</topic><topic>Single photon emission computed tomography–computer tomography (SPECT–CT)</topic><topic>t-PA-ligands to galectins</topic><topic>t-PApeptide1LAC</topic><topic>Tissue Plasminogen Activator - metabolism</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenberger, I.</creatorcontrib><creatorcontrib>Strauss, A.</creatorcontrib><creatorcontrib>Dobiasch, S.</creatorcontrib><creatorcontrib>Weis, C.</creatorcontrib><creatorcontrib>Szanyi, S.</creatorcontrib><creatorcontrib>Gil-Iceta, L.</creatorcontrib><creatorcontrib>Alonso, E.</creatorcontrib><creatorcontrib>González Esparza, M.</creatorcontrib><creatorcontrib>Gómez-Vallejo, V.</creatorcontrib><creatorcontrib>Szczupak, B.</creatorcontrib><creatorcontrib>Plaza-García, S.</creatorcontrib><creatorcontrib>Mirzaei, S.</creatorcontrib><creatorcontrib>Israel, L.L.</creatorcontrib><creatorcontrib>Bianchessi, S.</creatorcontrib><creatorcontrib>Scanziani, E.</creatorcontrib><creatorcontrib>Lellouche, J.-P.</creatorcontrib><creatorcontrib>Knoll, P.</creatorcontrib><creatorcontrib>Werner, J.</creatorcontrib><creatorcontrib>Felix, K.</creatorcontrib><creatorcontrib>Grenacher, L.</creatorcontrib><creatorcontrib>Reese, T.</creatorcontrib><creatorcontrib>Kreuter, J.</creatorcontrib><creatorcontrib>Jiménez-González, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenberger, I.</au><au>Strauss, A.</au><au>Dobiasch, S.</au><au>Weis, C.</au><au>Szanyi, S.</au><au>Gil-Iceta, L.</au><au>Alonso, E.</au><au>González Esparza, M.</au><au>Gómez-Vallejo, V.</au><au>Szczupak, B.</au><au>Plaza-García, S.</au><au>Mirzaei, S.</au><au>Israel, L.L.</au><au>Bianchessi, S.</au><au>Scanziani, E.</au><au>Lellouche, J.-P.</au><au>Knoll, P.</au><au>Werner, J.</au><au>Felix, K.</au><au>Grenacher, L.</au><au>Reese, T.</au><au>Kreuter, J.</au><au>Jiménez-González, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2015-09-28</date><risdate>2015</risdate><volume>214</volume><spage>76</spage><epage>84</epage><pages>76-84</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><abstract>Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose, magnetic, biodegradable nanoparticles prepared using recombinant human serum albumin (rHSA) and incorporated iron oxide (maghemite, γ-Fe2O3) nanoparticles were developed. Galectin-1 has been chosen as target receptor as this protein is upregulated in pancreatic cancer and its precursor lesions but not in healthy pancreatic tissue nor in pancreatitis. Tissue plasminogen activator derived peptides (t-PA-ligands), that have a high affinity to galectin-1 have been chosen as target moieties and were covalently attached onto the nanoparticle surface. Improved targeting and imaging properties were shown in mice using single photon emission computed tomography–computer tomography (SPECT–CT), a handheld gamma camera, and magnetic resonance imaging (MRI).
[Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26192099</pmid><doi>10.1016/j.jconrel.2015.07.017</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 2015-09, Vol.214, p.76-84 |
| issn | 0168-3659 1873-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1706209371 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Line, Tumor Ferric Compounds - chemistry Galectin 1 - chemistry Galectin 1 - metabolism Handheld gamma camera Humans Maghemite Magnetic Resonance Imaging Magnetic resonance imaging (MRI) Magnetics Magnetite Nanoparticles Mice Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Radionuclide Imaging Radiopharmaceuticals Recombinant Proteins - chemistry rHSA nanoparticles Serum Albumin - chemistry Single photon emission computed tomography–computer tomography (SPECT–CT) t-PA-ligands to galectins t-PApeptide1LAC Tissue Plasminogen Activator - metabolism Tomography, Emission-Computed, Single-Photon Xenograft Model Antitumor Assays |
| title | Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T00%3A35%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Targeted%20diagnostic%20magnetic%20nanoparticles%20for%20medical%20imaging%20of%20pancreatic%20cancer&rft.jtitle=Journal%20of%20controlled%20release&rft.au=Rosenberger,%20I.&rft.date=2015-09-28&rft.volume=214&rft.spage=76&rft.epage=84&rft.pages=76-84&rft.issn=0168-3659&rft.eissn=1873-4995&rft_id=info:doi/10.1016/j.jconrel.2015.07.017&rft_dat=%3Cproquest_cross%3E1706209371%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1706209371&rft_id=info:pmid/26192099&rft_els_id=S0168365915300304&rfr_iscdi=true |