Irisin-encoding gene ( FNDC5 ) variant is associated with changes in blood pressure and lipid profile in type 2 diabetic women but not in men

Abstract Introduction Irisin has recently been described as a novel myokine, which reduces visceral obesity and improves glucose metabolism in mice. Thus, polymorphisms in the gene encoding irisin, fibronectin type III domain containing 5 ( FNDC5 ), may be associated with type 2 diabetes mellitus (T...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2015-09, Vol.64 (9), p.952-957
Hauptverfasser:	Brondani, Letícia A, Boelter, Gabriela, Assmann, Taís S, Leitão, Cristiane B, Canani, Luís H, Crispim, Daisy
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Blood pressure Blood Pressure - genetics Cholesterol - blood Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - physiopathology Dyslipidemia Endocrinology & Metabolism Female Fibronectins - genetics Fibronectins - physiology FNDC5 gene Gene Frequency Genotype Glycated Hemoglobin A - metabolism Heterozygote Humans Irisin Linkage Disequilibrium Lipids - blood Male Middle Aged Polymorphism, Genetic - genetics Sex Characteristics Type 2 diabetes mellitus
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