Enantioselective Synthesis of (−)-Dysiherbaine

Dysiherbaine, a natural product isolated from the Marine sponge Dysidea herbacea, has been shown to be a selective agonist of non-NMDA type glutamate receptors, kainate receptors. An enantioselective synthesis of dysiherbaine is reported. Metathesis of the diene followed by conversion of the resulti...

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Veröffentlicht in:	Organic letters 2015-08, Vol.17 (16), p.3972-3974
Hauptverfasser:	Do, Ha, Kang, Chang Won, Cho, Joon Hyung, Gilbertson, Scott R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - chemical synthesis Alanine - chemistry Alanine - pharmacology Alkenes - chemistry Amino Acids - chemistry Animals Biological Products - chemical synthesis Biological Products - chemistry Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis Bridged Bicyclo Compounds, Heterocyclic - chemistry Bridged Bicyclo Compounds, Heterocyclic - pharmacology Marine Biology Molecular Structure Porifera - chemistry Receptors, Glutamate - drug effects Receptors, Kainic Acid - drug effects Stereoisomerism
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